Lisa Millgård Sagberg1,2, Even Hovig Fyllingen3,4, Tor Ivar Hansen5,6, Per Sveino Strand7,5, Aril Løge Håvik8,9, Terje Sundstrøm8,10, Alba Corell11,12, Asgeir Store Jakola11,12, Øyvind Salvesen13, Ole Solheim7,5. 1. Department of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. lisa.millgard.sagberg@ntnu.no. 2. Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. lisa.millgard.sagberg@ntnu.no. 3. Department of Radiology and Nuclear Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 4. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. 5. Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway. 6. Department of Physical Medicine and Rehabilitation, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 7. Department of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 8. Department of Clinical Medicine, University of Bergen, Bergen, Norway. 9. Department of Neurology, Molde Hospital, Molde, Norway. 10. Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway. 11. Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden. 12. Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden. 13. Clinical Research Unit, Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Abstract
PURPOSE: Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma. METHODS: In a multicenter case-control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model. RESULTS: We found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma. CONCLUSION: Intracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume.
PURPOSE: Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma. METHODS: In a multicenter case-control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model. RESULTS: We found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma. CONCLUSION: Intracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume.
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