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Literature DB >> 3145862

Synergistic effect of dosage and bacterial inoculum in TEM-1 mediated antibiotic resistance.

J A Reguera¹, F Baquero, J C Perez-Diaz, J L Martinez.

Abstract

The effect of inoculum size and gene dosage on the level of antibiotic resistance mediated by TEM-1 beta-lactamase was measured. From the results it seemed that gene dosage is a more efficient mechanism than inoculum size for increasing TEM-1 mediated resistance to beta-lactam antibiotics. It also seemed that the two mechanisms for enhancing antibiotic resistance are synergistic. The clinical implications of these results are discussed.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1988 PMID： 3145862 DOI： 10.1007/bf01975047

Source DB: PubMed Journal: Eur J Clin Microbiol Infect Dis ISSN： 0934-9723 Impact factor: 3.267

8 in total

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Journal: J Antimicrob Chemother Date: 1987-04 Impact factor: 5.790

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Authors: D E Fry; R N Garrison; L Trachtenberg; H C Polk
Journal: Surg Gynecol Obstet Date: 1985-02

Review 3. Resistance to beta-lactams in gram-negative bacteria: relative contributions of beta-lactamase and permeability limitations.

Authors: J H Nayler
Journal: J Antimicrob Chemother Date: 1987-06 Impact factor: 5.790

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Authors: H Williams; A King; K Shannon; I Phillips
Journal: Lancet Date: 1988-02-06 Impact factor: 79.321

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Authors: T J Foster
Journal: Microbiol Rev Date: 1983-09

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Authors: R H Eng; S M Smith; C Cherubin
Journal: Antimicrob Agents Chemother Date: 1984-07 Impact factor: 5.191

7. beta-Lactam coselection of sensitive and TEM-1 beta-lactamase-producing subpopulations in heterogeneous Escherichia coli colonies.

Authors: F Baquero; M F Vicente; J C Pérez-Diaz
Journal: J Antimicrob Chemother Date: 1985-02 Impact factor: 5.790

8. beta-Lactamases and beta-lactam resistance in Escherichia coli.

Authors: G A Jacoby; L Sutton
Journal: Antimicrob Agents Chemother Date: 1985-11 Impact factor: 5.191

8 in total

Review 1. Mutation frequencies and antibiotic resistance.

Authors: J L Martinez; F Baquero
Journal: Antimicrob Agents Chemother Date: 2000-07 Impact factor: 5.191

2. Diversification of Escherichia coli expressing an SHV-type extended-spectrum beta-lactamase (ESBL) during a hospital outbreak: emergence of an ESBL-hyperproducing strain resistant to expanded-spectrum cephalosporins.

Authors: A Pałucha; B Mikiewicz; M Gniadkowski
Journal: Antimicrob Agents Chemother Date: 1999-02 Impact factor: 5.191

3. Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.

Authors: Carolina Alvarez-Ortega; Irith Wiegand; Jorge Olivares; Robert E W Hancock; José Luis Martínez
Journal: Antimicrob Agents Chemother Date: 2010-08-02 Impact factor: 5.191

4. Effect of hyperproduction of TEM-1 beta-lactamase on in vitro susceptibility of Escherichia coli to beta-lactam antibiotics.

Authors: P J Wu; K Shannon; I Phillips
Journal: Antimicrob Agents Chemother Date: 1994-03 Impact factor: 5.191