| Literature DB >> 31423670 |
Jinqiang Wang1,2, Zejun Wang1,2, Jicheng Yu3, Anna R Kahkoska4, John B Buse4, Zhen Gu1,2,3,5,6.
Abstract
Type 1 and advanced type 2 diabetes treatment involves daily injections or continuous infusion of exogenous insulin aimed at regulating blood glucose levels in the normoglycemic range. However, current options for insulin therapy are limited by the risk of hypoglycemia and are associated with suboptimal glycemic control outcomes. Therefore, a range of glucose-responsive components that can undergo changes in conformation or show alterations in intermolecular binding capability in response to glucose stimulation has been studied for ultimate integration into closed-loop insulin delivery or "smart insulin" systems. Here, an overview of the evolution and recent progress in the development of molecular approaches for glucose-responsive insulin delivery systems, a rapidly growing subfield of precision medicine, is presented. Three central glucose-responsive moieties, including glucose oxidase, phenylboronic acid, and glucose-binding molecules are examined in detail. Future opportunities and challenges regarding translation are also discussed.Entities:
Keywords: devices; diabetes treatment; drug delivery; glucose responsive; insulin delivery
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Year: 2019 PMID： 31423670 PMCID： PMC7141789 DOI： 10.1002/adma.201902004
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849