| Literature DB >> 31371581 |
Kevin Gori1, Andrea Strakova1, Adrian Baez-Ortega1, Janice L Allen2, Karen M Allum3, Leontine Bansse-Issa4, Thinlay N Bhutia5, Jocelyn L Bisson1,6, Cristóbal Briceño7, Artemio Castillo Domracheva8, Anne M Corrigan9, Hugh R Cran10, Jane T Crawford11, Eric Davis12, Karina F de Castro13, Andrigo B de Nardi14, Anna P de Vos15, Laura Delgadillo Keenan16, Edward M Donelan2, Adela R Espinoza Huerta17, Ibikunle A Faramade18, Mohammed Fazil19, Eleni Fotopoulou20, Skye N Fruean21, Fanny Gallardo-Arrieta22, Olga Glebova23, Pagona G Gouletsou24, Rodrigo F Häfelin Manrique25, Joaquim J G P Henriques26, Rodrigo S Horta27, Natalia Ignatenko28, Yaghouba Kane29, Cathy King3, Debbie Koenig3, Ada Krupa30, Steven J Kruzeniski17, Young-Mi Kwon1, Marta Lanza-Perea9, Mihran Lazyan31, Adriana M Lopez Quintana32, Thibault Losfelt33, Gabriele Marino34, Simón Martínez Castañeda35, Mayra F Martínez-López36,37, Michael Meyer38, Edward J Migneco39, Berna Nakanwagi40, Karter B Neal41, Winifred Neunzig3, Máire Ní Leathlobhair1, Sally J Nixon42, Antonio Ortega-Pacheco43, Francisco Pedraza-Ordoñez44, Maria C Peleteiro45, Katherine Polak46, Ruth J Pye47, John F Reece48, Jose Rojas Gutierrez49, Haleema Sadia50, Sheila K Schmeling51, Olga Shamanova52, Alan G Sherlock47, Maximilian Stammnitz1, Audrey E Steenland-Smit4, Alla Svitich53, Lester J Tapia Martínez17, Ismail Thoya Ngoka54, Cristian G Torres55, Elizabeth M Tudor56, Mirjam G van der Wel57, Bogdan A Viţălaru58, Sevil A Vural59, Oliver Walkinton47, Jinhong Wang1, Alvaro S Wehrle-Martinez60, Sophie A E Widdowson61, Michael R Stratton62, Ludmil B Alexandrov63, Iñigo Martincorena62, Elizabeth P Murchison64.
Abstract
The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution.Entities:
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Year: 2019 PMID： 31371581 PMCID： PMC7116271 DOI： 10.1126/science.aau9923
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728