| Literature DB >> 31298867 |
Min-Ji Ryu1, Sunghoon Hwang2, Sojeong Kim3, Inho Yang4, Dong-Chan Oh2, Sang-Jip Nam1, William Fenical5.
Abstract
Meroterpenoids, meroindenon (1) and merochlorins E (2) and F (3), were isolated from a marine-derived bacterium belonging to the genus Streptomyces. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds 1-3 possess a tetrahydroxynaphthalene core and a C15-isoprene unit. Compounds 2 and 3 exhibited strong antibacterial activities against B. subtilis, K. rhizophila, and S. aureus, with a range of MIC values from 1 to 2 μg/mL.Entities:
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Year: 2019 PMID: 31298867 DOI: 10.1021/acs.orglett.9b01440
Source DB: PubMed Journal: Org Lett ISSN: 1523-7052 Impact factor: 6.005