Covering: Up to January 2020Meroterpenoids derived from the polyketide 1,3,6,8-tetrahydroxynaphthalene (THN) are complex natural products produced exclusively by Streptomyces bacteria. These antibacterial compounds include the napyradiomycins, merochlorins, marinones, and furaquinocins and have inspired many attempts at their chemical synthesis. In this review, we highlight the role played by biosynthetic studies in the stimulation of biomimetic and, ultimately, chemoenzymatic total syntheses of these natural products. In particular, the application of genome mining techniques to marine Streptomyces bacteria led to the discovery of unique prenyltransferase and vanadium-dependent haloperoxidase enzymes that can be used as highly selective biocatalysts in fully enzymatic total syntheses, thus overcoming the limitations of purely chemical reagents.
Covering: Up to Januan class="Chemical">ry 2020Meroterpenoidsderived from the polyketide 1,3,6,8-tetrahydroxynaphthalene (THN) are complex natural products produced exclusively by Streptomycesbacteria. These antibacterial compounds include the napyradiomycins, merochlorins, marinones, andfuraquinocins and have inspired many attempts at their chemical synthesis. In this review, we highlight the role playedby biosynthetic studies in the stimulation of biomimetic and, ultimately, chemoenzymatic total syntheses of these natural products. In particular, the application of genome mining techniques to marine Streptomycesbacteria led to the discovery of unique prenyltransferase and vanadium-dependent haloperoxidase enzymes that can be used as highly selective biocatalysts in fully enzymatic total syntheses, thus overcoming the limitations of purely chemicalreagents.
Authors: Shaun M K McKinnie; Zachary D Miles; Peter A Jordan; Takayoshi Awakawa; Henry P Pepper; Lauren A M Murray; Jonathan H George; Bradley S Moore Journal: J Am Chem Soc Date: 2018-12-14 Impact factor: 15.419
Authors: Lauren A M Murray; Shaun M K McKinnie; Henry P Pepper; Reto Erni; Zachary D Miles; Michelle C Cruickshank; Borja López-Pérez; Bradley S Moore; Jonathan H George Journal: Angew Chem Int Ed Engl Date: 2018-07-23 Impact factor: 15.336
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