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Literature DB >> 31290487

A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.

Emil S Iqbal¹, Stacie L Richardson¹, Nicolas A Abrigo¹, Kara K Dods¹, H Estheban Osorio Franco¹, Heather S Gerrish¹, Hari Kiran Kotapati², Iain M Morgan³, Douglas S Masterson², Matthew C T Hartman¹.

Abstract

Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2019 PMID： 31290487 PMCID： PMC7077329 DOI： 10.1039/c8cc10192b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

40 in total

1. Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.

Authors: V Döring; H D Mootz; L A Nangle; T L Hendrickson; V de Crécy-Lagard; P Schimmel; P Marlière
Journal: Science Date: 2001-04-20 Impact factor: 47.728

2. In vitro selection of mRNA display libraries containing an unnatural amino acid.

Authors: Shuwei Li; Steven Millward; Richard Roberts
Journal: J Am Chem Soc Date: 2002-08-28 Impact factor: 15.419

3. Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.

Authors: Yusuke Yamagishi; Ikuo Shoji; Shoji Miyagawa; Takashi Kawakami; Takayuki Katoh; Yuki Goto; Hiroaki Suga
Journal: Chem Biol Date: 2011-12-23

4. Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function.

Authors: Michal-Ruth Schweiger; Jianxin You; Peter M Howley
Journal: J Virol Date: 2006-05 Impact factor: 5.103

Review 5. Review stapling peptides using cysteine crosslinking.

Authors: David P Fairlie; Aline Dantas de Araujo
Journal: Biopolymers Date: 2016-11 Impact factor: 2.505

6. Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides.

Authors: Koki Sakagami; Toshihiro Masuda; Kenichi Kawano; Shiroh Futaki
Journal: Mol Pharm Date: 2018-02-21 Impact factor: 4.939

7. A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1.

Authors: Winifred Boner; Ewan R Taylor; Emmanouella Tsirimonaki; Kazuhiko Yamane; M Saveria Campo; Iain M Morgan
Journal: J Biol Chem Date: 2002-04-04 Impact factor: 5.157

Review 8. Papillomaviruses in the causation of human cancers - a brief historical account.

Authors: Harald zur Hausen
Journal: Virology Date: 2009-01-08 Impact factor: 3.616

9. A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling.

Authors: Alexander M Spokoyny; Yekui Zou; Jingjing J Ling; Hongtao Yu; Yu-Shan Lin; Bradley L Pentelute
Journal: J Am Chem Soc Date: 2013-04-16 Impact factor: 15.419

10. Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.

Authors: Yong S Chang; Bradford Graves; Vincent Guerlavais; Christian Tovar; Kathryn Packman; Kwong-Him To; Karen A Olson; Kamala Kesavan; Pranoti Gangurde; Aditi Mukherjee; Theresa Baker; Krzysztof Darlak; Carl Elkin; Zoran Filipovic; Farooq Z Qureshi; Hongliang Cai; Pamela Berry; Eric Feyfant; Xiangguo E Shi; James Horstick; D Allen Annis; Anthony M Manning; Nader Fotouhi; Huw Nash; Lyubomir T Vassilev; Tomi K Sawyer
Journal: Proc Natl Acad Sci U S A Date: 2013-08-14 Impact factor: 11.205

5 in total

A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.

1. Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.

2. In vitro selection of mRNA display libraries containing an unnatural amino acid.

3. Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library.

4. Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function.

Review 5. Review stapling peptides using cysteine crosslinking.

6. Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides.

7. A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1.

Review 8. Papillomaviruses in the causation of human cancers - a brief historical account.

9. A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling.

10. Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.

Review 1. Directing evolution of novel ligands by mRNA display.

2. Expanding the Chemical Diversity of Genetically Encoded Libraries.

3. Modulation of Coiled-Coil Binding Strength and Fusogenicity through Peptide Stapling.

Review 4. Small and Simple, yet Sturdy: Conformationally Constrained Peptides with Remarkable Properties.

5. Photocontrolled DNA minor groove interactions of imidazole/pyrrole polyamides.