Shih-Wei Hsu1,2,3, Chi-Li Gong4, Huai-Mei Hsu1,5, Chih-Chang Chao6, Yun-Chi Wang5, Wen-Shin Chang5, Yueh-Ting Tsai5, Liang-Chun Shih1,7, Chia-Wen Tsai5, DA-Tian Bau8,5,9. 1. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. 2. Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C. 3. National Defense Medical Center, Taipei, Taiwan, R.O.C. 4. Department of Physiology, China Medical University, Taichung, Taiwan, R.O.C. 5. Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital, Taichung, Taiwan, R.O.C. 6. Institute of Neurosciences, National Chengchi University, Taipei, Taiwan, R.O.C. 7. Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan, R.O.C. 8. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 9. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
Abstract
BACKGROUND/AIM: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. MATERIALS AND METHODS: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. RESULTS: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. CONCLUSION: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis. Copyright
BACKGROUND/AIM: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. MATERIALS AND METHODS: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPCpatients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. RESULTS: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. CONCLUSION: CT and TT genotypes at MMP2C-1306T were associated with a significantly decreased risk of NPC metastasis. Copyright