Meng-Feng Wu1,2,3, Yun-Chi Wang1,2, Te-Chun Shen1,2, Wen-Shin Chang1,2, Hsin-Ting Li2, Cheng-Hsi Liao1,2, Chi-Li Gong2, Zhi-Hong Wang4, Chia-Wen Tsai5,2, Te-Chun Hsia6,7,8, DA-Tian Bau5,2,9. 1. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. 2. Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. 3. Division of Chest Surgery, Department of Surgery, Taoyuan Armed Forces General Hospital, Taoyuan, Taiwan, R.O.C. 4. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C. 5. Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 6. Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 7. Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C. 8. Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. 9. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
Abstract
BACKGROUND/AIM: Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility. MATERIALS AND METHODS: IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancer patients and 716 controls via the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology. RESULTS: The highlight finding is that the distributions of genotypic (p=8.6E-10) and allelic (p=0.0001) frequencies of IL-16 rs11556218 was significantly different between cases and controls. In detail, the frequencies of IL-16 rs11556218 heterozygous variant TG and homozygous variant GG were 36.6 and 7.3% among the lung cancer patients, significantly higher than those among the controls (22.5% and 2.6%). On the other way, no difference was observed regarding IL-16 rs4778889 or IL-16 rs4072111. CONCLUSION: The present study indicates IL-16 rs11556218 G allele is significantly associated with increased Taiwan lung cancer risk. Copyright
BACKGROUND/AIM: Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility. MATERIALS AND METHODS:IL-16rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancerpatients and 716 controls via the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology. RESULTS: The highlight finding is that the distributions of genotypic (p=8.6E-10) and allelic (p=0.0001) frequencies of IL-16rs11556218 was significantly different between cases and controls. In detail, the frequencies of IL-16rs11556218 heterozygous variant TG and homozygous variant GG were 36.6 and 7.3% among the lung cancerpatients, significantly higher than those among the controls (22.5% and 2.6%). On the other way, no difference was observed regarding IL-16rs4778889 or IL-16rs4072111. CONCLUSION: The present study indicates IL-16rs11556218 G allele is significantly associated with increased Taiwan lung cancer risk. Copyright
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