Yu-Chao Lin1, Wen-Shin Chang2, Te-Chun Shen2, Hsin-Ting Li2,3, Chia-Hsiang Li2, Yu-Chen Hsiau2, Yun-Chi Wang2, Cheng-Nan Wu4, Chi-Li Gong2, Zhi-Hong Wang5, Chia-Wen Tsai6,4, Te-Chun Hsia6, DA-Tian Bau7,2,8. 1. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. 2. Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. 3. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, R.O.C. 4. Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C. 5. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C. 6. Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 7. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 8. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
Abstract
AIM: The aim of this study was to evaluate the contribution of human mouse double minute 2 (MDM2) gene polymorphisms to the risk of Taiwan lung cancer. MATERIALS AND METHODS: In this case-control study, the association of MDM2 rs2279744 genotypes with lung cancer risk was investigated among 358 lung cancer patients and 716 age-, gender- and smoking status-matched controls in Taiwan. RESULTS: The percentages of MDM2 rs2279744 GT and GG genotypes were 50.0% and 27.4% in lung cancer group and 50.0% and 26.5% in control group, respectively [odds ratio (OR)=1.03 and 1.07, 95% confidence interval (CI)=0.75-1.43 and 0.75-1.53, respectively]. The analysis about allelic frequency showed that G allele at MDM2 rs2279744 conferred a non-significant increased cancer risk (OR=1.03, 95%CI=0.86-1.24). CONCLUSION: Polymorphisms of MDM2 rs2279744 may play a role in lung carcinogenesis. However, the studied genotypes were not shown as predictors of lung cancer susceptibility. Copyright
AIM: The aim of this study was to evaluate the contribution of humanmouse double minute 2 (MDM2) gene polymorphisms to the risk of Taiwan lung cancer. MATERIALS AND METHODS: In this case-control study, the association of MDM2rs2279744 genotypes with lung cancer risk was investigated among 358 lung cancerpatients and 716 age-, gender- and smoking status-matched controls in Taiwan. RESULTS: The percentages of MDM2rs2279744 GT and GG genotypes were 50.0% and 27.4% in lung cancer group and 50.0% and 26.5% in control group, respectively [odds ratio (OR)=1.03 and 1.07, 95% confidence interval (CI)=0.75-1.43 and 0.75-1.53, respectively]. The analysis about allelic frequency showed that G allele at MDM2rs2279744 conferred a non-significant increased cancer risk (OR=1.03, 95%CI=0.86-1.24). CONCLUSION: Polymorphisms of MDM2rs2279744 may play a role in lung carcinogenesis. However, the studied genotypes were not shown as predictors of lung cancer susceptibility. Copyright
Authors: P Alhopuro; S K Ylisaukko-Oja; W J Koskinen; P Bono; J Arola; H J Järvinen; J-P Mecklin; T Atula; R Kontio; A A Mäkitie; S Suominen; I Leivo; P Vahteristo; L-M Aaltonen; L A Aaltonen Journal: J Med Genet Date: 2005-09 Impact factor: 6.318
Authors: Robert J Hancox; Richie Poulton; David Welch; Nelly Olova; Christene R McLachlan; Justina M Greene; Malcolm R Sears; Avshalom Caspi; Terrie E Moffitt; Stephen P Robertson; Antony W Braithwaite Journal: Hum Genet Date: 2009-06-12 Impact factor: 4.132