Chia-Wen Tsai1, Chien-Chih Yu2, DA-Tian Bau3,1,4, Chin-Nan Chu5,6, Yun-Chi Wang1, Wen-Shin Chang1, Zhi-Hong Wang7, Liang-Chih Liu1, Shao-Chun Wang1, Cheng-Chieh Lin1, Ting-Yuan Liu1, Jan-Gowth Chang1. 1. Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C. 2. School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C. 3. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. datian@mail.cmuh.org.tw artbau2@gmail.com. 4. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C. 5. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. 6. Division of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C. 7. Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
Abstract
BACKGROUND/AIM: The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese. MATERIALS AND METHODS: A total of 1232 breast cancer patients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. RESULTS: Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were not differentially distributed between case and control groups. Consistently, there was no difference in the distribution of allelic frequencies among patients and controls. CONCLUSION: IL-4 rs2243248, rs2243250 and rs2070874 do not confer breast cancer susceptibility in Taiwanese. Copyright
BACKGROUND/AIM: The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese. MATERIALS AND METHODS: A total of 1232 breast cancerpatients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. RESULTS: Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were not differentially distributed between case and control groups. Consistently, there was no difference in the distribution of allelic frequencies among patients and controls. CONCLUSION:IL-4 rs2243248, rs2243250 and rs2070874 do not confer breast cancer susceptibility in Taiwanese. Copyright
Authors: J B César-Neto; P M Duarte; M C G de Oliveira; C H Tambeli; E A Sallum; F H Nociti Journal: J Periodontal Res Date: 2007-04 Impact factor: 4.419
Authors: Beatriz Sanchez-Correa; Juan M Bergua; Carmen Campos; Inmaculada Gayoso; Maria Jose Arcos; Helena Bañas; Sara Morgado; Javier G Casado; Rafael Solana; Raquel Tarazona Journal: Cytokine Date: 2013-01-26 Impact factor: 3.861
Authors: Sara H Olson; Irene Orlow; Jennifer Simon; Diana Tommasi; Pampa Roy; Sharon Bayuga; Emmy Ludwig; Ann G Zauber; Robert C Kurtz Journal: Cancer Detect Prev Date: 2007-11-26