Literature DB >> 31211231

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis.

Jennifer Beauvarlet1, Jean-Louis Mergny2,3,4,5, Mojgan Djavaheri-Mergny1,6,7.   

Abstract

G-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.

Entities:  

Keywords:  Cancer therapy; DNA damage response; G-quadruplex; autophagy; senescence

Year:  2019        PMID： 31211231      PMCID： PMC6548482          DOI： 10.1080/23723556.2019.1604047

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Unraveling the relationship between structure and stabilization of triarylpyridines as G-quadruplex binding ligands.

Authors:  N M Smith; Gaëlle Labrunie; Ben Corry; Phong Lan Thao Tran; Marck Norret; Mojgan Djavaheri-Mergny; Colin L Raston; Jean-Louis Mergny
Journal:  Org Biomol Chem       Date:  2011-07-13       Impact factor: 3.876

Review 2.  Molecular definitions of autophagy and related processes.

Authors:  Lorenzo Galluzzi; Eric H Baehrecke; Andrea Ballabio; Patricia Boya; José Manuel Bravo-San Pedro; Francesco Cecconi; Augustine M Choi; Charleen T Chu; Patrice Codogno; Maria Isabel Colombo; Ana Maria Cuervo; Jayanta Debnath; Vojo Deretic; Ivan Dikic; Eeva-Liisa Eskelinen; Gian Maria Fimia; Simone Fulda; David A Gewirtz; Douglas R Green; Malene Hansen; J Wade Harper; Marja Jäättelä; Terje Johansen; Gabor Juhasz; Alec C Kimmelman; Claudine Kraft; Nicholas T Ktistakis; Sharad Kumar; Beth Levine; Carlos Lopez-Otin; Frank Madeo; Sascha Martens; Jennifer Martinez; Alicia Melendez; Noboru Mizushima; Christian Münz; Leon O Murphy; Josef M Penninger; Mauro Piacentini; Fulvio Reggiori; David C Rubinsztein; Kevin M Ryan; Laura Santambrogio; Luca Scorrano; Anna Katharina Simon; Hans-Uwe Simon; Anne Simonsen; Nektarios Tavernarakis; Sharon A Tooze; Tamotsu Yoshimori; Junying Yuan; Zhenyu Yue; Qing Zhong; Guido Kroemer
Journal:  EMBO J       Date:  2017-06-08       Impact factor: 11.598

Review 3.  DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential.

Authors:  Robert Hänsel-Hertsch; Marco Di Antonio; Shankar Balasubramanian
Journal:  Nat Rev Mol Cell Biol       Date:  2017-02-22       Impact factor: 94.444

4.  Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage.

Authors:  Nicola Ivan Orlotti; Graziella Cimino-Reale; Erika Borghini; Marzia Pennati; Claudia Sissi; Federica Perrone; Manlio Palumbo; Maria Grazia Daidone; Marco Folini; Nadia Zaffaroni
Journal:  Autophagy       Date:  2012-05-25       Impact factor: 16.016

Review 5.  Targeting autophagy in cancer.

Authors:  Jean M Mulcahy Levy; Christina G Towers; Andrew Thorburn
Journal:  Nat Rev Cancer       Date:  2017-07-28       Impact factor: 60.716

6.  G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells.

Authors:  Wen-Jun Zhou; Rong Deng; Xiao-Yue Zhang; Gong-Kan Feng; Lian-Quan Gu; Xiao-Feng Zhu
Journal:  Mol Cancer Ther       Date:  2009-12       Impact factor: 6.261

Review 7.  DNA damage and the balance between survival and death in cancer biology.

Authors:  Wynand P Roos; Adam D Thomas; Bernd Kaina
Journal:  Nat Rev Cancer       Date:  2015-12-18       Impact factor: 60.716

Review 8.  The autophagic network and cancer.

Authors:  Marissa D Rybstein; José Manuel Bravo-San Pedro; Guido Kroemer; Lorenzo Galluzzi
Journal:  Nat Cell Biol       Date:  2018-02-23       Impact factor: 28.824

9.  Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells.

Authors:  Jennifer Beauvarlet; Paul Bensadoun; Elodie Darbo; Gaelle Labrunie; Benoît Rousseau; Elodie Richard; Irena Draskovic; Arturo Londono-Vallejo; Jean-William Dupuy; Rabindra Nath Das; Aurore Guédin; Guillaume Robert; Francois Orange; Sabrina Croce; Valerie Valesco; Pierre Soubeyran; Kevin M Ryan; Jean-Louis Mergny; Mojgan Djavaheri-Mergny
Journal:  Nucleic Acids Res       Date:  2019-04-08       Impact factor: 16.971

Review 10.  The dynamic nature of senescence in cancer.

Authors:  Soyoung Lee; Clemens A Schmitt
Journal:  Nat Cell Biol       Date:  2019-01-02       Impact factor: 28.824
  10 in total
  1 in total

Review 1.  ATM Kinase-Dependent Regulation of Autophagy: A Key Player in Senescence?

Authors:  Venturina Stagni; Alessandra Ferri; Claudia Cirotti; Daniela Barilà
Journal:  Front Cell Dev Biol       Date:  2021-01-07
  1 in total

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