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Literature DB >> 30602768

The dynamic nature of senescence in cancer.

Soyoung Lee^1,2,3, Clemens A Schmitt^4,5,6.

Abstract

Cellular senescence is implicated in physiological and pathological processes spanning development, wound healing, age-related decline in organ functions and cancer. Here, we discuss cell-autonomous and non-cell-autonomous properties of senescence in the context of tumour formation and anticancer therapy, and characterize these properties, such as reprogramming into stemness, tissue remodelling and immune crosstalk, as far more dynamic than suggested by the common view of senescence as an irreversible, static condition.

Entities: Chemical

Mesh：

Year: 2019 PMID： 30602768 DOI： 10.1038/s41556-018-0249-2

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

125 in total

1. The serial cultivation of human diploid cell strains.

Authors: L HAYFLICK; P S MOORHEAD
Journal: Exp Cell Res Date: 1961-12 Impact factor: 3.905

Review 2. The essence of senescence.

Authors: Thomas Kuilman; Chrysiis Michaloglou; Wolter J Mooi; Daniel S Peeper
Journal: Genes Dev Date: 2010-11-15 Impact factor: 11.361

3. A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Authors: G P Dimri; X Lee; G Basile; M Acosta; G Scott; C Roskelley; E E Medrano; M Linskens; I Rubelj; O Pereira-Smith
Journal: Proc Natl Acad Sci U S A Date: 1995-09-26 Impact factor: 11.205

4. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors: M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal: Cell Date: 1997-03-07 Impact factor: 41.582

Review 5. Inside and out: the activities of senescence in cancer.

Authors: Pedro A Pérez-Mancera; Andrew R J Young; Masashi Narita
Journal: Nat Rev Cancer Date: 2014-07-17 Impact factor: 60.716

Review 6. Senescence-messaging secretome: SMS-ing cellular stress.

Authors: Thomas Kuilman; Daniel S Peeper
Journal: Nat Rev Cancer Date: 2009-01-09 Impact factor: 60.716

Review 7. Role of Telomeres and Telomerase in Aging and Cancer.

Authors: Jerry W Shay
Journal: Cancer Discov Date: 2016-03-30 Impact factor: 39.397

Review 8. Cellular senescence in aging and age-related disease: from mechanisms to therapy.

Authors: Bennett G Childs; Matej Durik; Darren J Baker; Jan M van Deursen
Journal: Nat Med Date: 2015-12 Impact factor: 53.440

Review 9. The senescence-associated secretory phenotype: the dark side of tumor suppression.

Authors: Jean-Philippe Coppé; Pierre-Yves Desprez; Ana Krtolica; Judith Campisi
Journal: Annu Rev Pathol Date: 2010 Impact factor: 23.472

10. Global reorganization of the nuclear landscape in senescent cells.

Authors: Tamir Chandra; Philip Andrew Ewels; Stefan Schoenfelder; Mayra Furlan-Magaril; Steven William Wingett; Kristina Kirschner; Jean-Yves Thuret; Simon Andrews; Peter Fraser; Wolf Reik
Journal: Cell Rep Date: 2015-01-29 Impact factor: 9.423

156 in total

1. Radiolabeling of Theranostic Nanosystems.

Authors: Sudeep Das; Surachet Imlimthan; Anu J Airaksinen; Mirkka Sarparanta
Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622

2. Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles.

Authors: Liu Han; Qilai Long; Shenjun Li; Qixia Xu; Boyi Zhang; Xuefeng Dou; Min Qian; Yannasittha Jiramongkol; Jianming Guo; Liu Cao; Y Eugene Chin; Eric W-F Lam; Jing Jiang; Yu Sun
Journal: Cancer Res Date: 2020-05-04 Impact factor: 12.701

3. Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.

Authors: Sugyun An; Si-Young Cho; Junsoo Kang; Soobeom Lee; Hyung-Su Kim; Dae-Jin Min; EuiDong Son; Kwang-Hyun Cho
Journal: Proc Natl Acad Sci U S A Date: 2020-11-23 Impact factor: 11.205

The dynamic nature of senescence in cancer.

1. The serial cultivation of human diploid cell strains.

Review 2. The essence of senescence.

3. A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

4. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Review 5. Inside and out: the activities of senescence in cancer.

Review 6. Senescence-messaging secretome: SMS-ing cellular stress.

Review 7. Role of Telomeres and Telomerase in Aging and Cancer.

Review 8. Cellular senescence in aging and age-related disease: from mechanisms to therapy.

Review 9. The senescence-associated secretory phenotype: the dark side of tumor suppression.

10. Global reorganization of the nuclear landscape in senescent cells.

1. Radiolabeling of Theranostic Nanosystems.

2. Senescent Stromal Cells Promote Cancer Resistance through SIRT1 Loss-Potentiated Overproduction of Small Extracellular Vesicles.

3. Inhibition of 3-phosphoinositide-dependent protein kinase 1 (PDK1) can revert cellular senescence in human dermal fibroblasts.

4. Methods to Study Myc-Regulated Cellular Senescence: An Update.

Review 5. p53: 800 million years of evolution and 40 years of discovery.

Review 6. Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity.

7. Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms.

8. Calcitriol Prevents RAD51 Loss and cGAS-STING-IFN Response Triggered by Progerin.

Review 9. How the ageing microenvironment influences tumour progression.

Review 10. The use of non-traditional models in the study of cancer resistance-the case of the naked mole rat.