Literature DB >> 3118225

Is all cyclo(His-Pro) derived from thyrotropin-releasing hormone?

C Prasad1, A Jayaraman, H J Robertson, J K Rao.   

Abstract

Cyclo(His-Pro), or histidyl-proline diketopiperazine, is an endogenous cyclic dipeptide that is ubiquitously distributed in tissues and body fluids of both man and animals. This cyclic dipeptide is not only structurally related to thyrotropin-releasing hormone (TRH, pGlu-His-ProNH2), but it can also arise from TRH by the action of the enzyme pyroglutamate amino-peptidase (pGlu-peptidase). The data on the distribution of TRH, cyclo(His-Pro), and pGlu-peptidase under normal and abnormal conditions are summarized and potential relationships analyzed. We conclude that all of the cyclo(His-Pro) cannot be derived from TRH. Two additional sources of cyclo(His-Pro) are suggested. It is proposed that 29,247 molecular weight TRH prohormone, prepro TRH, which contains 5 copies of TRH sequence, can be processed to yield cyclo(His-Pro). Thus, both TRH and cyclo(His-Pro) share a common precursor, prepro[TRH/Cyclo(His-Pro)].

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Year:  1987        PMID： 3118225     DOI： 10.1007/bf00971513

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  36 in total

1.  On the mechanism of fasting-associated elevations in hypothalamic cyclo(His-Pro) content.

Authors:  C Prasad; T Iriuchijima; R M Edwards; J F Wilber; M Mori; D J Rogers
Journal:  Neurochem Res       Date:  1986-03       Impact factor: 3.996

2.  Thyrotropin-releasing hormone precursor: characterization in rat brain.

Authors:  R M Lechan; P Wu; I M Jackson; H Wolf; S Cooperman; G Mandel; R H Goodman
Journal:  Science       Date:  1986-01-10       Impact factor: 47.728

3.  Processing of the thyrotropin releasing hormone (TRH) precursor in Xenopus skin and bovine hypothalamus: evidence for the existence of extended forms of TRH.

Authors:  S M Cockle; D G Smyth
Journal:  Regul Pept       Date:  1986-05

4.  Localisation of gonadotropin-releasing and thyrotropin-releasing hormones in human brain by radioimmunoassay.

Authors:  E Okon; Y Koch
Journal:  Nature       Date:  1976-09-23       Impact factor: 49.962

5.  Evidence for the presence of immunoreactive histidyl-proline diketopiperazine [cyclo (His-Pro)] in the adult human brain.

Authors:  C R Parker; M Mori; J Pegues; C Prasad; J F Wilber
Journal:  Peptides       Date:  1983 Nov-Dec       Impact factor: 3.750

6.  Metabolism of thyrotropin-releasing hormone in human cerebrospinal fluid. Isolation and characterization of pyroglutamate aminopeptidase activity.

Authors:  C Prasad; A Jayaraman
Journal:  Brain Res       Date:  1986-02-05       Impact factor: 3.252

7.  Thyrotropin releasing hormone: development of inactivation system during maturation of the rat.

Authors:  J T Neary; J D Kieffer; P Federico; H Mover; F Maloof; M Soodak
Journal:  Science       Date:  1976-07-30       Impact factor: 47.728

8.  Thyrotropin-releasing hormone (TRH): Measurements in human spinal fluid.

Authors:  G E Shambaugh; J F Wilber; E Montoya; H Ruder; E R Blonsky
Journal:  J Clin Endocrinol Metab       Date:  1975-07       Impact factor: 5.958

9.  Histidyl-proline diketopiperazine decreases food intake in rats.

Authors:  J E Morley; A S Levine; C Prasad
Journal:  Brain Res       Date:  1981-04-06       Impact factor: 3.252

10.  Regional dissociation of histidyl--proline diketopiperazine (cyclo-(His--Pro)) and thyrotropin-releasing hormone (TRH) in the rat brain.

Authors:  M Mori; C Prasad; J F Wilber
Journal:  Brain Res       Date:  1982-01-14       Impact factor: 3.252
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  3 in total

1.  Kinetics and pattern of degradation of thyrotropin-releasing hormone (TRH) in human plasma.

Authors:  J Møss; H Bundgaard
Journal:  Pharm Res       Date:  1990-07       Impact factor: 4.200

2.  Evidence for pyroglutamyl peptidase I and prolyl endopeptidase activities in the rat insulinoma cell line RINm 5F: lack of relationship with TRH metabolism.

Authors:  P Salers; L H Ouafik; P Giraud; A Dutour; J Y Maltese; C Oliver
Journal:  Mol Cell Biochem       Date:  1991-07-24       Impact factor: 3.396

3.  Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates.

Authors:  Hasan Turkez; Ivana Cacciatore; Mehmet Enes Arslan; Erika Fornasari; Lisa Marinelli; Antonio Di Stefano; Adil Mardinoglu
Journal:  Biomolecules       Date:  2020-05-09
  3 in total

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