Literature DB >> 3084982

On the mechanism of fasting-associated elevations in hypothalamic cyclo(His-Pro) content.

C Prasad, T Iriuchijima, R M Edwards, J F Wilber, M Mori, D J Rogers.   

Abstract

Potential mechanism(s) underlying the fasting-associated rise in hypothalamic cyclo(His-Pro) content was explored by examining the effects of 24-hour fasting on: (i) cyclo(His-Pro) synthesis from TRH, (ii) cyclo(His-Pro) metabolism, and (iii) cyclo (His-Pro) secretion by hypothalamic tissue in vitro. The data presented here show that none of these three variables were altered due to fasting. Two additional potential changes that could cause cyclo(His-Pro) elevations during fasting are suggested. These include an in vivo decrease in hypothalamic cyclo(His-Pro) secretion that may not be apparent in vitro, and/or an increase in the synthesis of cyclo(His-Pro) from a precursor(s) other than TRH.

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Year:  1986        PMID： 3084982     DOI： 10.1007/bf00965008

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  13 in total

1.  Antagonism of ethanol narcosis by histidyl-proline diketopiperazine.

Authors:  C Prasad; T Matsui; A Peterkofsky
Journal:  Nature       Date:  1977-07-14       Impact factor: 49.962

2.  Distribution and characterization of cyclo(His-Pro)-like immunoreactivity in the rat gastrointestinal tract.

Authors:  M Mori; J Pegues; C Prasad; R M Edwards; J F Wilber
Journal:  Biochem Biophys Res Commun       Date:  1982-12-15       Impact factor: 3.575

3.  Gonadotropin-releasing hormone and thyrotropin-releasing hormone: distribution and effects in the central nervous system.

Authors:  J F Wilber; E Montoya; N P Plotnikoff; W F White; R Gendrick; L Renaud; J B Martin
Journal:  Recent Prog Horm Res       Date:  1976

4.  Specific radioimmunoassay of cyclo (His-Pro), a biologically active metabolite of thyrotropin-releasing hormone.

Authors:  M Mori; C Prasad; J F Wilber
Journal:  Endocrinology       Date:  1981-05       Impact factor: 4.736

5.  [3H]Cyclo(histidyl-proline) in rat tissues: distribution, clearance and binding.

Authors:  Y Koch; F Battaini; A Peterkofsky
Journal:  Biochem Biophys Res Commun       Date:  1982-01-29       Impact factor: 3.575

6.  Demonstration of pyroglutamylpeptidase and amidase activities toward thyrotropin-releasing hormone in hamster hypothalamus extracts.

Authors:  C Prasad; A Peterkofsky
Journal:  J Biol Chem       Date:  1976-06-10       Impact factor: 5.157

7.  Histidyl-proline diketopiperazine decreases food intake in rats.

Authors:  J E Morley; A S Levine; C Prasad
Journal:  Brain Res       Date:  1981-04-06       Impact factor: 3.252

8.  Downregulation of adrenocortical cyclo (His-Pro)-binding sites by cyclo (His-Pro) administration to neonatal but not adult rats.

Authors:  C Prasad; R M Edwards
Journal:  Neurosci Lett       Date:  1984-08-24       Impact factor: 3.046

9.  Regional dissociation of histidyl--proline diketopiperazine (cyclo-(His--Pro)) and thyrotropin-releasing hormone (TRH) in the rat brain.

Authors:  M Mori; C Prasad; J F Wilber
Journal:  Brain Res       Date:  1982-01-14       Impact factor: 3.252

10.  Distribution and metabolism of cyclo (His-Pro): a new member of the neuropeptide family.

Authors:  C Prasad; M Mori; J F Wilber; W Pierson; J Pegues; A Jayaraman
Journal:  Peptides       Date:  1982 May-Jun       Impact factor: 3.750
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  1 in total

Review 1.  Is all cyclo(His-Pro) derived from thyrotropin-releasing hormone?

Authors:  C Prasad; A Jayaraman; H J Robertson; J K Rao
Journal:  Neurochem Res       Date:  1987-09       Impact factor: 3.996
  1 in total

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