Literature DB >> 31164372

Oncogenic NRG1 Fusions: A New Hope for Targeted Therapy in Pancreatic Cancer.

Andrew J Aguirre1,2.   

Abstract

Approximately 8%-10% of pancreatic ductal adenocarcinoma cases are KRAS wild type. In a subset of these tumors, NRG1 gene fusions have been identified as targetable oncogenic drivers, a discovery that highlights the importance of deep molecular characterization for KRAS wild-type pancreatic cancers and provides a novel treatment strategy in this disease.See related article by Jones et al., p. 4674. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 31164372      PMCID： PMC6679796          DOI： 10.1158/1078-0432.CCR-19-1280

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  10 in total

1.  Genomic analyses identify molecular subtypes of pancreatic cancer.

Authors:  Peter Bailey; David K Chang; Katia Nones; Amber L Johns; Ann-Marie Patch; Marie-Claude Gingras; David K Miller; Angelika N Christ; Tim J C Bruxner; Michael C Quinn; Craig Nourse; L Charles Murtaugh; Ivon Harliwong; Senel Idrisoglu; Suzanne Manning; Ehsan Nourbakhsh; Shivangi Wani; Lynn Fink; Oliver Holmes; Venessa Chin; Matthew J Anderson; Stephen Kazakoff; Conrad Leonard; Felicity Newell; Nick Waddell; Scott Wood; Qinying Xu; Peter J Wilson; Nicole Cloonan; Karin S Kassahn; Darrin Taylor; Kelly Quek; Alan Robertson; Lorena Pantano; Laura Mincarelli; Luis N Sanchez; Lisa Evers; Jianmin Wu; Mark Pinese; Mark J Cowley; Marc D Jones; Emily K Colvin; Adnan M Nagrial; Emily S Humphrey; Lorraine A Chantrill; Amanda Mawson; Jeremy Humphris; Angela Chou; Marina Pajic; Christopher J Scarlett; Andreia V Pinho; Marc Giry-Laterriere; Ilse Rooman; Jaswinder S Samra; James G Kench; Jessica A Lovell; Neil D Merrett; Christopher W Toon; Krishna Epari; Nam Q Nguyen; Andrew Barbour; Nikolajs Zeps; Kim Moran-Jones; Nigel B Jamieson; Janet S Graham; Fraser Duthie; Karin Oien; Jane Hair; Robert Grützmann; Anirban Maitra; Christine A Iacobuzio-Donahue; Christopher L Wolfgang; Richard A Morgan; Rita T Lawlor; Vincenzo Corbo; Claudio Bassi; Borislav Rusev; Paola Capelli; Roberto Salvia; Giampaolo Tortora; Debabrata Mukhopadhyay; Gloria M Petersen; Donna M Munzy; William E Fisher; Saadia A Karim; James R Eshleman; Ralph H Hruban; Christian Pilarsky; Jennifer P Morton; Owen J Sansom; Aldo Scarpa; Elizabeth A Musgrove; Ulla-Maja Hagbo Bailey; Oliver Hofmann; Robert L Sutherland; David A Wheeler; Anthony J Gill; Richard A Gibbs; John V Pearson; Nicola Waddell; Andrew V Biankin; Sean M Grimmond
Journal:  Nature       Date:  2016-02-24       Impact factor: 49.962

2.  Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma.

Authors: 
Journal:  Cancer Cell       Date:  2017-08-14       Impact factor: 31.743

3.  Identification of Targetable ALK Rearrangements in Pancreatic Ductal Adenocarcinoma.

Authors:  Aatur D Singhi; Siraj M Ali; Jill Lacy; Andrew Hendifar; Khanh Nguyen; Jamie Koo; Jon H Chung; Joel Greenbowe; Jeffrey S Ross; Marina N Nikiforova; Herbert J Zeh; Inderpal S Sarkaria; Anil Dasyam; Nathan Bahary
Journal:  J Natl Compr Canc Netw       Date:  2017-05       Impact factor: 11.908

4.  NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer.

Authors:  Christoph Heining; Peter Horak; Sebastian Uhrig; Paula L Codo; Barbara Klink; Barbara Hutter; Martina Fröhlich; David Bonekamp; Daniela Richter; Katja Steiger; Roland Penzel; Volker Endris; Karl Roland Ehrenberg; Stephanie Frank; Kortine Kleinheinz; Umut H Toprak; Matthias Schlesner; Ranadip Mandal; Lothar Schulz; Helmut Lambertz; Sebastian Fetscher; Michael Bitzer; Nisar P Malek; Marius Horger; Nathalia A Giese; Oliver Strobel; Thilo Hackert; Christoph Springfeld; Lars Feuerbach; Frank Bergmann; Evelin Schröck; Christof von Kalle; Wilko Weichert; Claudia Scholl; Claudia R Ball; Albrecht Stenzinger; Benedikt Brors; Stefan Fröhling; Hanno Glimm
Journal:  Cancer Discov       Date:  2018-05-25       Impact factor: 39.397

5.  NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma.

Authors:  Martin R Jones; Laura M Williamson; James T Topham; Michael K C Lee; Angela Goytain; Julie Ho; Robert E Denroche; GunHo Jang; Erin Pleasance; Yaoquing Shen; Joanna M Karasinska; John P McGhie; Sharlene Gill; Howard J Lim; Malcolm J Moore; Hui-Li Wong; Tony Ng; Stephen Yip; Wei Zhang; Sara Sadeghi; Carolyn Reisle; Andrew J Mungall; Karen L Mungall; Richard A Moore; Yussanne Ma; Jennifer J Knox; Steven Gallinger; Janessa Laskin; Marco A Marra; David F Schaeffer; Steven J M Jones; Daniel J Renouf
Journal:  Clin Cancer Res       Date:  2019-05-08       Impact factor: 12.531

6.  Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer.

Authors:  M R Jones; H Lim; Y Shen; E Pleasance; C Ch'ng; C Reisle; S Leelakumari; C Zhao; S Yip; J Ho; E Zhong; T Ng; D Ionescu; D F Schaeffer; A J Mungall; K L Mungall; Y Zhao; R A Moore; Y Ma; S Chia; C Ho; D J Renouf; K Gelmon; S J M Jones; M A Marra; J Laskin
Journal:  Ann Oncol       Date:  2017-12-01       Impact factor: 32.976

7.  Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.

Authors:  Andrew J Aguirre; Jonathan A Nowak; Nicholas D Camarda; Richard A Moffitt; Arezou A Ghazani; Mehlika Hazar-Rethinam; Srivatsan Raghavan; Jaegil Kim; Lauren K Brais; Dorisanne Ragon; Marisa W Welch; Emma Reilly; Devin McCabe; Lori Marini; Kristin Anderka; Karla Helvie; Nelly Oliver; Ana Babic; Annacarolina Da Silva; Brandon Nadres; Emily E Van Seventer; Heather A Shahzade; Joseph P St Pierre; Kelly P Burke; Thomas Clancy; James M Cleary; Leona A Doyle; Kunal Jajoo; Nadine J McCleary; Jeffrey A Meyerhardt; Janet E Murphy; Kimmie Ng; Anuj K Patel; Kimberly Perez; Michael H Rosenthal; Douglas A Rubinson; Marvin Ryou; Geoffrey I Shapiro; Ewa Sicinska; Stuart G Silverman; Rebecca J Nagy; Richard B Lanman; Deborah Knoerzer; Dean J Welsch; Matthew B Yurgelun; Charles S Fuchs; Levi A Garraway; Gad Getz; Jason L Hornick; Bruce E Johnson; Matthew H Kulke; Robert J Mayer; Jeffrey W Miller; Paul B Shyn; David A Tuveson; Nikhil Wagle; Jen Jen Yeh; William C Hahn; Ryan B Corcoran; Scott L Carter; Brian M Wolpin
Journal:  Cancer Discov       Date:  2018-06-14       Impact factor: 39.397

8.  CD74-NRG1 fusions in lung adenocarcinoma.

Authors:  Lynnette Fernandez-Cuesta; Dennis Plenker; Hirotaka Osada; Ruping Sun; Roopika Menon; Frauke Leenders; Sandra Ortiz-Cuaran; Martin Peifer; Marc Bos; Juliane Daßler; Florian Malchers; Jakob Schöttle; Wenzel Vogel; Ilona Dahmen; Mirjam Koker; Roland T Ullrich; Gavin M Wright; Prudence A Russell; Zoe Wainer; Benjamin Solomon; Elisabeth Brambilla; Hélène Nagy-Mignotte; Denis Moro-Sibilot; Christian G Brambilla; Sylvie Lantuejoul; Janine Altmüller; Christian Becker; Peter Nürnberg; Johannes M Heuckmann; Erich Stoelben; Iver Petersen; Joachim H Clement; Jörg Sänger; Lucia A Muscarella; Annamaria la Torre; Vito M Fazio; Idoya Lahortiga; Timothy Perera; Souichi Ogata; Marc Parade; Dirk Brehmer; Martin Vingron; Lukas C Heukamp; Reinhard Buettner; Thomas Zander; Jürgen Wolf; Sven Perner; Sascha Ansén; Stefan A Haas; Yasushi Yatabe; Roman K Thomas
Journal:  Cancer Discov       Date:  2014-01-27       Impact factor: 39.397

9.  Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers.

Authors:  Alexander Drilon; Romel Somwar; Biju P Mangatt; Henrik Edgren; Patrice Desmeules; Anja Ruusulehto; Roger S Smith; Lukas Delasos; Morana Vojnic; Andrew J Plodkowski; Joshua Sabari; Kenneth Ng; Joseph Montecalvo; Jason Chang; Huichun Tai; William W Lockwood; Victor Martinez; Gregory J Riely; Charles M Rudin; Mark G Kris; Maria E Arcila; Christopher Matheny; Ryma Benayed; Natasha Rekhtman; Marc Ladanyi; Gopinath Ganji
Journal:  Cancer Discov       Date:  2018-04-02       Impact factor: 39.397

Review 10.  Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer.

Authors:  Lynnette Fernandez-Cuesta; Roman K Thomas
Journal:  Clin Cancer Res       Date:  2014-12-11       Impact factor: 12.531
  10 in total
  6 in total

Review 1.  Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data.

Authors:  Ashton A Connor; Steven Gallinger
Journal:  Nat Rev Cancer       Date:  2021-11-17       Impact factor: 60.716

Review 2.  The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go.

Authors:  Elizabeth D Thompson; Nicholas J Roberts; Laura D Wood; James R Eshleman; Michael G Goggins; Scott E Kern; Alison P Klein; Ralph H Hruban
Journal:  Mod Pathol       Date:  2020-07-23       Impact factor: 7.842

3.  Longitudinal analysis of cell-free mutated KRAS and CA 19-9 predicts survival following curative resection of pancreatic cancer.

Authors:  Saskia Hussung; Dilara Akhoundova; Julian Hipp; Marie Follo; Rhena F U Klar; Ulrike Philipp; Florian Scherer; Nikolas von Bubnoff; Justus Duyster; Melanie Boerries; Uwe Wittel; Ralph M Fritsch
Journal:  BMC Cancer       Date:  2021-01-11       Impact factor: 4.430

Review 4.  Precision Medicine of Hepatobiliary and Pancreatic Cancers: Focusing on Clinical Trial Outcomes.

Authors:  Takehiko Tsumura; Keitaro Doi; Hiroyuki Marusawa
Journal:  Cancers (Basel)       Date:  2022-07-28       Impact factor: 6.575

Review 5.  NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents.

Authors:  J Laskin; S V Liu; K Tolba; C Heining; R F Schlenk; P Cheema; J Cadranel; M R Jones; A Drilon; A Cseh; S Gyorffy; F Solca; M Duruisseaux
Journal:  Ann Oncol       Date:  2020-09-09       Impact factor: 51.769

6.  Challenges of the current precision medicine approach for pancreatic cancer: A single institution experience between 2013 and 2017.

Authors:  Ding Ding; Ammar A Javed; Dea Cunningham; Jonathan Teinor; Michael Wright; Zunaira N Javed; Cara Wilt; Lindsay Parish; Mary Hodgin; Amy Ryan; Carol Judkins; Keith McIntyre; Rachel Klein; Nilo Azad; Valerie Lee; Ross Donehower; Ana De Jesus-Acosta; Adrian Murphy; Dung T Le; Eun Ji Shin; Anne Marie Lennon; Mouen Khashab; Vikesh Singh; Alison P Klein; Nicholas J Roberts; Amy Hacker-Prietz; Lindsey Manos; Christi Walsh; Lara Groshek; Caitlin Brown; Chunhui Yuan; Alex B Blair; Vincent Groot; Georgios Gemenetzis; Jun Yu; Matthew J Weiss; Richard A Burkhart; William R Burns; Jin He; John L Cameron; Amol Narang; Atif Zaheer; Elliot K Fishman; Elizabeth D Thompson; Robert Anders; Ralph H Hruban; Elizabeth Jaffee; Christopher L Wolfgang; Lei Zheng; Daniel A Laheru
Journal:  Cancer Lett       Date:  2020-10-28       Impact factor: 8.679
  6 in total

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