Literature DB >> 32704031

The genetics of ductal adenocarcinoma of the pancreas in the year 2020: dramatic progress, but far to go.

Elizabeth D Thompson1,2, Nicholas J Roberts1,2, Laura D Wood1,2, James R Eshleman1,2, Michael G Goggins1,2,3, Scott E Kern1,2, Alison P Klein1,2, Ralph H Hruban4,5.   

Abstract

The publication of the "Pan-Cancer Atlas" by the Pan-Cancer Analysis of Whole Genomes Consortium, a partnership formed by The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC), provides a wonderful opportunity to reflect on where we stand in our understanding of the genetics of pancreatic cancer, as well as on the opportunities to translate this understanding to patient care. From germline variants that predispose to the development of pancreatic cancer, to somatic mutations that are therapeutically targetable, genetics is now providing hope, where there once was no hope, for those diagnosed with pancreatic cancer.

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Year:  2020        PMID： 32704031      PMCID： PMC8375585          DOI： 10.1038/s41379-020-0629-6

Source DB:  PubMed          Journal:  Mod Pathol        ISSN： 0893-3952            Impact factor:   7.842


  215 in total

1.  Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype.

Authors:  Maeve A Lowery; Emmet J Jordan; Olca Basturk; Ryan N Ptashkin; Ahmet Zehir; Michael F Berger; Tanisha Leach; Brian Herbst; Gokce Askan; Hannah Maynard; Danielle Glassman; Christina Covington; Nikolaus Schultz; Ghassan K Abou-Alfa; James J Harding; David S Klimstra; Jaclyn F Hechtman; David M Hyman; Peter J Allen; William R Jarnagin; Vinod P Balachandran; Anna M Varghese; Mark A Schattner; Kenneth H Yu; Leonard B Saltz; David B Solit; Christine A Iacobuzio-Donahue; Steven D Leach; Eileen M O'Reilly
Journal:  Clin Cancer Res       Date:  2017-07-28       Impact factor: 12.531

Review 2.  Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer.

Authors:  Louis Buscail; Barbara Bournet; Pierre Cordelier
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2020-01-31       Impact factor: 46.802

3.  Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial.

Authors:  Lorraine A Chantrill; Adnan M Nagrial; Clare Watson; Amber L Johns; Mona Martyn-Smith; Skye Simpson; Scott Mead; Marc D Jones; Jaswinder S Samra; Anthony J Gill; Nicole Watson; Venessa T Chin; Jeremy L Humphris; Angela Chou; Belinda Brown; Adrienne Morey; Marina Pajic; Sean M Grimmond; David K Chang; David Thomas; Lucille Sebastian; Katrin Sjoquist; Sonia Yip; Nick Pavlakis; Ray Asghari; Sandra Harvey; Peter Grimison; John Simes; Andrew V Biankin
Journal:  Clin Cancer Res       Date:  2015-05-01       Impact factor: 12.531

4.  Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial.

Authors:  Kyaw L Aung; Sandra E Fischer; Robert E Denroche; Gun-Ho Jang; Anna Dodd; Sean Creighton; Bernadette Southwood; Sheng-Ben Liang; Dianne Chadwick; Amy Zhang; Grainne M O'Kane; Hamzeh Albaba; Shari Moura; Robert C Grant; Jessica K Miller; Faridah Mbabaali; Danielle Pasternack; Ilinca M Lungu; John M S Bartlett; Sangeet Ghai; Mathieu Lemire; Spring Holter; Ashton A Connor; Richard A Moffitt; Jen Jen Yeh; Lee Timms; Paul M Krzyzanowski; Neesha Dhani; David Hedley; Faiyaz Notta; Julie M Wilson; Malcolm J Moore; Steven Gallinger; Jennifer J Knox
Journal:  Clin Cancer Res       Date:  2017-12-29       Impact factor: 12.531

5.  Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers.

Authors:  Suman Mukhopadhyay; Debanjan Goswami; Pavan P Adiseshaiah; William Burgan; Ming Yi; Theresa M Guerin; Serguei V Kozlov; Dwight V Nissley; Frank McCormick
Journal:  Cancer Res       Date:  2020-01-07       Impact factor: 12.701

6.  Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

Authors:  Siân Jones; Xiaosong Zhang; D Williams Parsons; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; Hirohiko Kamiyama; Antonio Jimeno; Seung-Mo Hong; Baojin Fu; Ming-Tseh Lin; Eric S Calhoun; Mihoko Kamiyama; Kimberly Walter; Tatiana Nikolskaya; Yuri Nikolsky; James Hartigan; Douglas R Smith; Manuel Hidalgo; Steven D Leach; Alison P Klein; Elizabeth M Jaffee; Michael Goggins; Anirban Maitra; Christine Iacobuzio-Donahue; James R Eshleman; Scott E Kern; Ralph H Hruban; Rachel Karchin; Nickolas Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728

7.  Patterns of somatic structural variation in human cancer genomes.

Authors:  Yilong Li; Nicola D Roberts; Jeremiah A Wala; Ofer Shapira; Steven E Schumacher; Kiran Kumar; Ekta Khurana; Sebastian Waszak; Jan O Korbel; James E Haber; Marcin Imielinski; Joachim Weischenfeldt; Rameen Beroukhim; Peter J Campbell
Journal:  Nature       Date:  2020-02-05       Impact factor: 49.962

8.  The evolutionary history of 2,658 cancers.

Authors:  Moritz Gerstung; Clemency Jolly; Ignaty Leshchiner; Stefan C Dentro; Santiago Gonzalez; Daniel Rosebrock; Thomas J Mitchell; Yulia Rubanova; Pavana Anur; Kaixian Yu; Maxime Tarabichi; Amit Deshwar; Jeff Wintersinger; Kortine Kleinheinz; Ignacio Vázquez-García; Kerstin Haase; Lara Jerman; Subhajit Sengupta; Geoff Macintyre; Salem Malikic; Nilgun Donmez; Dimitri G Livitz; Marek Cmero; Jonas Demeulemeester; Steven Schumacher; Yu Fan; Xiaotong Yao; Juhee Lee; Matthias Schlesner; Paul C Boutros; David D Bowtell; Hongtu Zhu; Gad Getz; Marcin Imielinski; Rameen Beroukhim; S Cenk Sahinalp; Yuan Ji; Martin Peifer; Florian Markowetz; Ville Mustonen; Ke Yuan; Wenyi Wang; Quaid D Morris; Paul T Spellman; David C Wedge; Peter Van Loo
Journal:  Nature       Date:  2020-02-06       Impact factor: 49.962

9.  Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.

Authors:  Eva G Alvarez; Adrian Baez-Ortega; Jorge Zamora; Fran Supek; Bernardo Rodriguez-Martin; Jonas Demeulemeester; Martin Santamarina; Young Seok Ju; Javier Temes; Daniel Garcia-Souto; Harald Detering; Yilong Li; Jorge Rodriguez-Castro; Ana Dueso-Barroso; Alicia L Bruzos; Stefan C Dentro; Miguel G Blanco; Gianmarco Contino; Daniel Ardeljan; Marta Tojo; Nicola D Roberts; Sonia Zumalave; Paul A W Edwards; Joachim Weischenfeldt; Montserrat Puiggròs; Zechen Chong; Ken Chen; Eunjung Alice Lee; Jeremiah A Wala; Keiran Raine; Adam Butler; Sebastian M Waszak; Fabio C P Navarro; Steven E Schumacher; Jean Monlong; Francesco Maura; Niccolo Bolli; Guillaume Bourque; Mark Gerstein; Peter J Park; David C Wedge; Rameen Beroukhim; David Torrents; Jan O Korbel; Inigo Martincorena; Rebecca C Fitzgerald; Peter Van Loo; Haig H Kazazian; Kathleen H Burns; Peter J Campbell; Jose M C Tubio
Journal:  Nat Genet       Date:  2020-02-05       Impact factor: 38.330

10.  Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.

Authors:  Isidro Cortés-Ciriano; Jake June-Koo Lee; Ruibin Xi; Dhawal Jain; Youngsook L Jung; Lixing Yang; Dmitry Gordenin; Leszek J Klimczak; Cheng-Zhong Zhang; David S Pellman; Peter J Park
Journal:  Nat Genet       Date:  2020-02-05       Impact factor: 38.330
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  9 in total

1.  Proteogenomic characterization of pancreatic ductal adenocarcinoma.

Authors:  Liwei Cao; Chen Huang; Daniel Cui Zhou; Yingwei Hu; T Mamie Lih; Sara R Savage; Karsten Krug; David J Clark; Michael Schnaubelt; Lijun Chen; Felipe da Veiga Leprevost; Rodrigo Vargas Eguez; Weiming Yang; Jianbo Pan; Bo Wen; Yongchao Dou; Wen Jiang; Yuxing Liao; Zhiao Shi; Nadezhda V Terekhanova; Song Cao; Rita Jui-Hsien Lu; Yize Li; Ruiyang Liu; Houxiang Zhu; Peter Ronning; Yige Wu; Matthew A Wyczalkowski; Hariharan Easwaran; Ludmila Danilova; Arvind Singh Mer; Seungyeul Yoo; Joshua M Wang; Wenke Liu; Benjamin Haibe-Kains; Mathangi Thiagarajan; Scott D Jewell; Galen Hostetter; Chelsea J Newton; Qing Kay Li; Michael H Roehrl; David Fenyö; Pei Wang; Alexey I Nesvizhskii; D R Mani; Gilbert S Omenn; Emily S Boja; Mehdi Mesri; Ana I Robles; Henry Rodriguez; Oliver F Bathe; Daniel W Chan; Ralph H Hruban; Li Ding; Bing Zhang; Hui Zhang
Journal:  Cell       Date:  2021-09-16       Impact factor: 66.850

Review 2.  The Desmoplastic Stroma of Pancreatic Cancer: Multilayered Levels of Heterogeneity, Clinical Significance, and Therapeutic Opportunities.

Authors:  Yohei Masugi
Journal:  Cancers (Basel)       Date:  2022-07-05       Impact factor: 6.575

3.  Neoplastic cell enrichment of tumor tissues using coring and laser microdissection for proteomic and genomic analyses of pancreatic ductal adenocarcinoma.

Authors:  Qing Kay Li; Yingwei Hu; Lijun Chen; Michael Schnaubelt; Daniel Cui Zhou; Yize Li; Rita Jui-Hsien Lu; Mathangi Thiagarajan; Galen Hostetter; Chelsea J Newton; Scott D Jewell; Gil Omenn; Ana I Robles; Mehdi Mesri; Oliver F Bathe; Bing Zhang; Li Ding; Ralph H Hruban; Daniel W Chan; Hui Zhang
Journal:  Clin Proteomics       Date:  2022-10-20       Impact factor: 5.000

4.  A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma.

Authors:  Bo Zhou; Jie Zhang; Hongda Zhu; Shugeng Wu
Journal:  J Oncol       Date:  2022-05-13       Impact factor: 4.501

5.  Pancreatic cancer cells spectral library by DIA-MS and the phenotype analysis of gemcitabine sensitivity.

Authors:  Ran Kong; Xiaohong Qian; Wantao Ying
Journal:  Sci Data       Date:  2022-06-09       Impact factor: 8.501

6.  Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer.

Authors:  Mohammad Azhar Kamal; Imran Siddiqui; Cristina Belgiovine; Marialuisa Barbagallo; Valentina Paleari; Daniela Pistillo; Chiara Chiabrando; Silvia Schiarea; Barbara Bottazzi; Roberto Leone; Roberta Avigni; Roberta Migliore; Paola Spaggiari; Francesca Gavazzi; Giovanni Capretti; Federica Marchesi; Alberto Mantovani; Alessandro Zerbi; Paola Allavena
Journal:  Cancers (Basel)       Date:  2022-05-27       Impact factor: 6.575

7.  Examination of ATM, BRCA1, and BRCA2 promoter methylation in patients with pancreatic cancer.

Authors:  Cancan Zhou; Nancy Porter; Michael Borges; Christian Gauthier; Lindsey Ferguson; Bo Huang; Neha Nanda; Jin He; Daniel Laheru; Ralph H Hruban; Michael Goggins; Alison P Klein; Nicholas J Roberts
Journal:  Pancreatology       Date:  2021-03-28       Impact factor: 3.977

Review 8.  Pancreatic cancer pathology viewed in the light of evolution.

Authors:  Michaël Noë; Seung-Mo Hong; Laura D Wood; Elizabeth D Thompson; Nicholas J Roberts; Michael G Goggins; Alison P Klein; James R Eshleman; Scott E Kern; Ralph H Hruban
Journal:  Cancer Metastasis Rev       Date:  2021-02-08       Impact factor: 9.237

Review 9.  [The microarchitecture of pancreatic cancer from the point of view of the pathologist and the radiologist].

Authors:  Philipp Mayer; Matthias M Gaida
Journal:  Pathologe       Date:  2021-05-06       Impact factor: 1.011
  9 in total

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