Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 ± 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 ± 1.21 years, ASD-LI: n = 21, 10.67 ± 1.20 years) and TD: n = 27, 10.14 ± 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235.
Abnormal auditory discrimination neural processes, indexed by mismatch fields (MMFs) recorded by magnetoencephalography (MEG), have been reported in verbal children with ASD. Association with clinical measures indicates that delayed MMF components are associated with poorer language and communication performance. At present, little is known about neural correlates of language and communication skills in extremely language impaired (minimally-verbal/non-verbal) children who have ASD: ASD-MVNV. It is hypothesized that MMF delays observed in language-impaired but nonetheless verbal children with ASD will be exacerbated in ASD-MVNV. The present study investigated this hypothesis, examining MMF responses bilaterally during an auditory oddball paradigm with vowel stimuli in ASD-MVNV, in a verbal ASD cohort without cognitive impairment and in typically developing (TD) children. The verbal ASD cohort without cognitive impairment was split into those demonstrating considerable language impairment (CELF core language index <85; "ASD-LI") versus those with less or no language impairment (CELF CLI >85; "ASD-V"). Eighty-four participants (8-12 years) were included in final analysis: ASD-MVNV: n = 9, 9.67 ± 1.41 years, ASD: n = 48, (ASD-V: n = 27, 10.55 ± 1.21 years, ASD-LI: n = 21, 10.67 ± 1.20 years) and TD: n = 27, 10.14 ± 1.38 years. Delayed MMF latencies were found bilaterally in ASD-MVNV compared to verbal ASD (both ASD-V and ASD-LI) and TD children. Delayed MMF responses were associated with diminished language and communication skills. Furthermore, whereas the TD children showed leftward lateralization of MMF amplitude, ASD-MVNV and verbal ASD (ASD-V and ASD-LI) showed abnormal rightward lateralization. Findings suggest delayed auditory discrimination processes and abnormal rightward laterality as objective markers of language/communication skills in both verbal and MVNV children who have ASD. Autism Res 2019, 12: 1225-1235.
Keywords:
autism spectrum disorder; language and communication skill; magnetoencephalography; minimally verbal/non-verbal children; vowel mismatch fields
Authors: Susan Risi; Catherine Lord; Katherine Gotham; Christina Corsello; Christina Chrysler; Peter Szatmari; Edwin H Cook; Bennett L Leventhal; Andrew Pickles Journal: J Am Acad Child Adolesc Psychiatry Date: 2006-09 Impact factor: 8.829
Authors: Elizabeth S Heller Murray; Jennifer Segawa; F Isik Karahanoglu; Catherine Tocci; Jason A Tourville; Alfonso Nieto-Castanon; Helen Tager-Flusberg; Dara S Manoach; Frank H Guenther Journal: Res Autism Spectr Disord Date: 2022-04-07
Authors: Heather L Green; J Christopher Edgar; Junko Matsuzaki; Timothy P L Roberts Journal: Neuroimaging Clin N Am Date: 2020-03-27 Impact factor: 2.264
Authors: Jussi Alho; Hari Bharadwaj; Sheraz Khan; Fahimeh Mamashli; Tyler K Perrachione; Ainsley Losh; Nicole M McGuiggan; Robert M Joseph; Matti S Hämäläinen; Tal Kenet Journal: Prog Neurobiol Date: 2021-05-24 Impact factor: 10.885
Authors: Timothy P L Roberts; Junko Matsuzaki; Lisa Blaskey; Luke Bloy; J Christopher Edgar; Mina Kim; Matthew Ku; Emily S Kuschner; David Embick Journal: Mol Autism Date: 2019-08-15 Impact factor: 7.509
Authors: Hari Bharadwaj; Fahimeh Mamashli; Sheraz Khan; Ravinderjit Singh; Robert M Joseph; Ainsley Losh; Stephanie Pawlyszyn; Nicole M McGuiggan; Steven Graham; Matti S Hämäläinen; Tal Kenet Journal: PLoS Biol Date: 2022-02-15 Impact factor: 8.029
Authors: Rachel Reetzke; Vini Singh; Ji Su Hong; Calliope B Holingue; Luther G Kalb; Natasha N Ludwig; Deepa Menon; Danika L Pfeiffer; Rebecca J Landa Journal: Front Psychol Date: 2022-09-06