Literature DB >> 14749724

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

Christian Haass1.   

Abstract

In 1959, Dave Brubeck and Paul Desmond revolutionized modern jazz music by composing their unforgettable Take Five in 5/4, one of the most defiant time signatures in all music. Of similar revolutionary importance for biomedical and basic biochemical research is the identification of the minimal set of genes required to obtain a deadly time bomb ticking in all of us: Alzheimer's disease. It now appears that one needs to Take Five genes to produce a deadly peptide by a proteolytic mechanism, which paradoxically is otherwise of pivotal importance for development and cell fate decisions.

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Year:  2004        PMID： 14749724      PMCID： PMC1271800          DOI： 10.1038/sj.emboj.7600061

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  48 in total

1.  Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

Authors:  G Struhl; A Adachi
Journal:  Mol Cell       Date:  2000-09       Impact factor: 17.970

2.  Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.

Authors:  Z Zhang; P Nadeau; W Song; D Donoviel; M Yuan; A Bernstein; B A Yankner
Journal:  Nat Cell Biol       Date:  2000-07       Impact factor: 28.824

3.  BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

Authors:  M Farzan; C E Schnitzler; N Vasilieva; D Leung; H Choe
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-15       Impact factor: 11.205

4.  Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.

Authors:  L Hong; G Koelsch; X Lin; S Wu; S Terzyan; A K Ghosh; X C Zhang; J Tang
Journal:  Science       Date:  2000-10-06       Impact factor: 47.728

5.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.

Authors:  G Yu; M Nishimura; S Arawaka; D Levitan; L Zhang; A Tandon; Y Q Song; E Rogaeva; F Chen; T Kawarai; A Supala; L Levesque; H Yu; D S Yang; E Holmes; P Milman; Y Liang; D M Zhang; D H Xu; C Sato; E Rogaev; M Smith; C Janus; Y Zhang; R Aebersold; L S Farrer; S Sorbi; A Bruni; P Fraser; P St George-Hyslop
Journal:  Nature       Date:  2000-09-07       Impact factor: 49.962

6.  Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Authors:  W P Esler; W T Kimberly; B L Ostaszewski; T S Diehl; C L Moore; J Y Tsai; T Rahmati; W Xia; D J Selkoe; M S Wolfe
Journal:  Nat Cell Biol       Date:  2000-07       Impact factor: 28.824

7.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Authors:  M S Wolfe; W Xia; B L Ostaszewski; T S Diehl; W T Kimberly; D J Selkoe
Journal:  Nature       Date:  1999-04-08       Impact factor: 49.962

8.  Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases.

Authors:  H Steiner; M Kostka; H Romig; G Basset; B Pesold; J Hardy; A Capell; L Meyn; M L Grim; R Baumeister; K Fechteler; C Haass
Journal:  Nat Cell Biol       Date:  2000-11       Impact factor: 28.824

9.  Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

Authors:  B De Strooper; P Saftig; K Craessaerts; H Vanderstichele; G Guhde; W Annaert; K Von Figura; F Van Leuven
Journal:  Nature       Date:  1998-01-22       Impact factor: 49.962

10.  Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Authors:  Y M Li; M Xu; M T Lai; Q Huang; J L Castro; J DiMuzio-Mower; T Harrison; C Lellis; A Nadin; J G Neduvelil; R B Register; M K Sardana; M S Shearman; A L Smith; X P Shi; K C Yin; J A Shafer; S J Gardell
Journal:  Nature       Date:  2000-06-08       Impact factor: 49.962
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  179 in total

1.  Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Authors:  Akio Fukumori; Regina Fluhrer; Harald Steiner; Christian Haass
Journal:  J Neurosci       Date:  2010-06-09       Impact factor: 6.167

2.  Functional consequences of the lack of amyloid precursor protein in the mouse dentate gyrus in vivo.

Authors:  Peter Jedlicka; Mirka Owen; Matej Vnencak; Jakob-A Tschäpe; Meike Hick; Ulrike C Müller; Thomas Deller
Journal:  Exp Brain Res       Date:  2011-11-11       Impact factor: 1.972

3.  Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.

Authors:  Christof Haffner; Mélanie Frauli; Stephanie Topp; Martin Irmler; Kay Hofmann; Jörg T Regula; Laure Bally-Cuif; Christian Haass
Journal:  EMBO J       Date:  2004-07-15       Impact factor: 11.598

Review 4.  Role of phosphoinositides at the neuronal synapse.

Authors:  Samuel G Frere; Belle Chang-Ileto; Gilbert Di Paolo
Journal:  Subcell Biochem       Date:  2012

5.  ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.

Authors:  Peer-Hendrik Kuhn; Huanhuan Wang; Bastian Dislich; Alessio Colombo; Ulrike Zeitschel; Joachim W Ellwart; Elisabeth Kremmer; Steffen Rossner; Stefan F Lichtenthaler
Journal:  EMBO J       Date:  2010-07-30       Impact factor: 11.598

6.  The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein.

Authors:  Sylvia Ullrich; Anna Münch; Stephanie Neumann; Elisabeth Kremmer; Jörg Tatzelt; Stefan F Lichtenthaler
Journal:  J Biol Chem       Date:  2010-04-28       Impact factor: 5.157

7.  Initiation and propagation of neurodegeneration.

Authors:  Christian Haass
Journal:  Nat Med       Date:  2010-09-21       Impact factor: 53.440

8.  The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice.

Authors:  Henri J Huttunen; Daniel Havas; Camilla Peach; Cory Barren; Stephan Duller; Weiming Xia; Matthew P Frosch; Birgit Hutter-Paier; Manfred Windisch; Dora M Kovacs
Journal:  J Neuropathol Exp Neurol       Date:  2010-08       Impact factor: 3.685

9.  Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation.

Authors:  Amy L Radke; Lauren E Reynolds; Rossana C N Melo; Ann M Dvorak; Peter F Weller; Lisa A Spencer
Journal:  Blood       Date:  2009-01-26       Impact factor: 22.113

10.  Can zebrafish be used as animal model to study Alzheimer's disease?

Authors:  Soraya Santana; Eduardo P Rico; Javier S Burgos
Journal:  Am J Neurodegener Dis       Date:  2012-05-15
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