Literature DB >> 1910331

Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family.

R Wooster1, L Sutherland, T Ebner, D Clarke, O Da Cruz e Silva, B Burchell.   

Abstract

A new human liver UDP-glucuronosyltransferase (HlugP4) has been cloned and expressed in cell culture. The expressed enzyme has a molecular mass of 56 kDa and preferentially catalysed the glucuronidation of halogenated and bulky alkyl phenols. The C-terminal half of the sequence (246 amino acids) is 96% identical with the same portion of HlugP1, whereas the N-terminal half of the deduced protein sequences are only 38% identical. These results suggest that the two isoenzymes may be derived from the same gene by differential splicing of the gene product.

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Year:  1991        PMID： 1910331      PMCID： PMC1151367          DOI： 10.1042/bj2780465

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  29 in total

1.  Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

Authors:  M Strathmann; T M Wilkie; M I Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

2.  Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase.

Authors:  T Iyanagi; M Haniu; K Sogawa; Y Fujii-Kuriyama; S Watanabe; J E Shively; K F Anan
Journal:  J Biol Chem       Date:  1986-11-25       Impact factor: 5.157

3.  Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA.

Authors:  M R Jackson; L R McCarthy; D Harding; S Wilson; M W Coughtrie; B Burchell
Journal:  Biochem J       Date:  1987-03-01       Impact factor: 3.857

Review 4.  UDP-glucuronosyltransferases.

Authors:  B Burchell; M W Coughtrie
Journal:  Pharmacol Ther       Date:  1989       Impact factor: 12.310

5.  Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells.

Authors:  D Harding; S Fournel-Gigleux; M R Jackson; B Burchell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

Review 6.  An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

Authors:  M Kozak
Journal:  Nucleic Acids Res       Date:  1987-10-26       Impact factor: 16.971

7.  Isolation and purification of two human liver UDP-glucuronosyltransferases.

Authors:  Y M Irshaid; T R Tephly
Journal:  Mol Pharmacol       Date:  1987-01       Impact factor: 4.436

8.  Examination of the substrate specificity of cloned rat kidney phenol UDP-glucuronyltransferase expressed in COS-7 cells.

Authors:  M R Jackson; S Fournel-Gigleux; D Harding; B Burchell
Journal:  Mol Pharmacol       Date:  1988-11       Impact factor: 4.436

9.  Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture.

Authors:  S Fournel-Gigleux; M R Jackson; R Wooster; B Burchell
Journal:  FEBS Lett       Date:  1989-01-30       Impact factor: 4.124

10.  Multiple sites of alternative splicing of the rat fibronectin gene transcript.

Authors:  J E Schwarzbauer; R S Patel; D Fonda; R O Hynes
Journal:  EMBO J       Date:  1987-09       Impact factor: 11.598
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  15 in total

1.  The novel UGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus.

Authors:  I S Owens; J K Ritter; M T Yeatman; F Chen
Journal:  J Pharmacokinet Biopharm       Date:  1996-10

2.  Orthotopic liver transplantation in liver-based metabolic disorders.

Authors:  A P Mowat
Journal:  Eur J Pediatr       Date:  1992       Impact factor: 3.183

3.  Photoaffinity labeling probe for the substrate binding site of human phenol sulfotransferase (SULT1A1): 7-azido-4-methylcoumarin.

Authors:  G Chen; E Battaglia; C Senay; C N Falany; A Radominska-Pandya
Journal:  Protein Sci       Date:  1999-10       Impact factor: 6.725

4.  Developmental aspects of human hepatic drug glucuronidation in young children and adults.

Authors:  C P Strassburg; A Strassburg; S Kneip; A Barut; R H Tukey; B Rodeck; M P Manns
Journal:  Gut       Date:  2002-02       Impact factor: 23.059

5.  The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach.

Authors:  Murali Munisamy; Manjari Tripathi; Madhuri Behari; S Raghavan; D C Jain; Barghavi Ramanujam; Karthik Arumugam; Thiyagu Rajakannan; Surulivel Rajan Mallayasamy; Vivekanandhan Subbiah
Journal:  Mol Diagn Ther       Date:  2013-10       Impact factor: 4.074

6.  Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1.

Authors:  Adam G Staines; Pavel Sindelar; Michael W H Coughtrie; Brian Burchell
Journal:  Biochem J       Date:  2004-12-15       Impact factor: 3.857

7.  Cosegregation of intragenic markers with a novel mutation that causes Crigler-Najjar syndrome type I: implication in carrier detection and prenatal diagnosis.

Authors:  N Moghrabi; D J Clarke; B Burchell; M Boxer
Journal:  Am J Hum Genet       Date:  1993-09       Impact factor: 11.025

8.  Activation of dioxin response element (DRE)-associated genes by benzo(a)pyrene 3,6-quinone and benzo(a)pyrene 1,6-quinone in MCF-10A human mammary epithelial cells.

Authors:  Scott W Burchiel; Todd A Thompson; Fredine T Lauer; Tudor I Oprea
Journal:  Toxicol Appl Pharmacol       Date:  2007-03-13       Impact factor: 4.219

9.  Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues.

Authors:  Athena Starlard-Davenport; Beverly Lyn-Cook; Anna Radominska-Pandya
Journal:  Steroids       Date:  2008-02-03       Impact factor: 2.668

10.  Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro.

Authors:  L T Erps; J K Ritter; J H Hersh; D Blossom; N C Martin; I S Owens
Journal:  J Clin Invest       Date:  1994-02       Impact factor: 14.808
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