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Literature DB >> 31023505

Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation.

Konstantin K Turoverov¹, Irina M Kuznetsova², Alexander V Fonin², April L Darling³, Boris Y Zaslavsky⁴, Vladimir N Uversky⁵.

Abstract

At the turn of this century, cardinal changes took place in the perceptions of the structure and function of proteins, as well as in the organizational principles of membrane-less organelles. As a result, the model of the organization of living matter is changing to one described by highly dynamic biological soft matter positioned at the edge of chaos. Intrinsically disordered proteins (IDPs) and membrane-less organelles are key examples of this new outlook and may represent a critical foundation of life, defining its complexity and the evolution of living things.

Entities: Disease

Keywords: biological soft matter; edge of chaos; emergent behavior; liquid-liquid phase transition

Mesh：

Substances：

Year: 2019 PMID： 31023505 DOI： 10.1016/j.tibs.2019.03.005

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

26 in total

Review 1. Features of molecular recognition of intrinsically disordered proteins via coupled folding and binding.

Authors: Jing Yang; Meng Gao; Junwen Xiong; Zhengding Su; Yongqi Huang
Journal: Protein Sci Date: 2019-09-04 Impact factor: 6.725

Review 2. Liquid-liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept.

Authors: Iuliia A Antifeeva; Alexander V Fonin; Anna S Fefilova; Olesya V Stepanenko; Olga I Povarova; Sergey A Silonov; Irina M Kuznetsova; Vladimir N Uversky; Konstantin K Turoverov
Journal: Cell Mol Life Sci Date: 2022-04-20 Impact factor: 9.261

Review 3. Protein conformation and biomolecular condensates.

Authors: Diego S Vazquez; Pamela L Toledo; Alejo R Gianotti; Mario R Ermácora
Journal: Curr Res Struct Biol Date: 2022-09-14

4. Production of nascent ribosome precursors within the nucleolar microenvironment of Saccharomyces cerevisiae.

Authors: Samantha Lin; Suchita Rajan; Sofia Lemberg; Mark Altawil; Katherine Anderson; Ruth Bryant; Sebastian Cappeta; Brandon Chin; Isabella Hamdan; Annelise Hamer; Rachel Hyzny; Andrew Karp; Daniel Lee; Alexandria Lim; Medha Nayak; Vishnu Palaniappan; Soomin Park; Sarika Satishkumar; Anika Seth; Uva Sri Dasari; Emili Toppari; Ayush Vyas; Julianne Walker; Evan Weston; Atif Zafar; Cecelia Zielke; Ganapati H Mahabeleshwar; Alan M Tartakoff
Journal: Genetics Date: 2022-07-04 Impact factor: 4.402

9. A quantitative calcium phosphate nanocluster model of the casein micelle: the average size, size distribution and surface properties.

Authors: Carl Holt
Journal: Eur Biophys J Date: 2021-04-18 Impact factor: 1.733

10. Unfolding and Aggregation of Lysozyme under the Combined Action of Dithiothreitol and Guanidine Hydrochloride: Optical Studies.

Authors: Ruslan M Sarimov; Vladimir N Binhi; Tatiana A Matveeva; Nikita V Penkov; Sergey V Gudkov
Journal: Int J Mol Sci Date: 2021-03-08 Impact factor: 5.923

Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation.

Review 1. Features of molecular recognition of intrinsically disordered proteins via coupled folding and binding.

Review 2. Liquid-liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept.

Review 3. Protein conformation and biomolecular condensates.

4. Production of nascent ribosome precursors within the nucleolar microenvironment of Saccharomyces cerevisiae.

Review 5. Substoichiometric action of long noncoding RNAs.

6. Hydration-mediated G-protein-coupled receptor activation.

7. Structural and Functional Insights into CP2c Transcription Factor Complexes.

Review 8. Advances in studying protein disorder with solid-state NMR.

9. A quantitative calcium phosphate nanocluster model of the casein micelle: the average size, size distribution and surface properties.

10. Unfolding and Aggregation of Lysozyme under the Combined Action of Dithiothreitol and Guanidine Hydrochloride: Optical Studies.