Literature DB >> 3098566

A comparative distribution study of 111In-labeled DTPA and TTHA monoclonal antibody conjugates in a choriocarcinoma xenograft model.

R G Buckley, P Barnett, F Searle, R Pedley, J A Boden.   

Abstract

Conjugates of the chelating agents DTPA and TTHA with a monoclonal anti-HCG were prepared. The tissue distribution of the 111In-labeled conjugates and also 111In-citrate was studied in mice bearing human choriocarcinoma xenografts. The antibody conjugates both gave high liver and spleen radionuclide accumulation. Elevated femur levels were observed for the TTHA conjugate and 111In-citrate. Generally the DTPA conjugate showed the highest tumor/tissue ratios, although its tumor/blood ratio was lower than the other two materials. The results infer that the DTPA conjugate has the greatest utility as an imaging agent but that it would require a background subtraction technique.

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Year:  1986        PMID： 3098566     DOI： 10.1007/bf00252197

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  12 in total

1.  111 In-chloride: a new agent for bone marrow imaging.

Authors:  D L Lilien; H G Berger; D P Anderson; L R Bennett
Journal:  J Nucl Med       Date:  1973-03       Impact factor: 10.057

Review 2.  Gallium-67 and indium-111 radiopharmaceuticals.

Authors:  M L Thakur
Journal:  Int J Appl Radiat Isot       Date:  1977 Jan-Feb

3.  An efficient method for labelling antibodies with 111In.

Authors:  R G Buckley; F Searle
Journal:  FEBS Lett       Date:  1984-01-23       Impact factor: 4.124

4.  Radioimmunolocalization of tumours by external scintigraphy after administration of 131I antibody to human chorionic gonadotrophin: preliminary communication.

Authors:  R H Begent; F Searle; G Stanway; R F Jewkes; B E Jones; P Vernon; K D Bagshawe
Journal:  J R Soc Med       Date:  1980-09       Impact factor: 5.344

5.  Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotropin.

Authors:  D M Goldenberg; E E Kim; F H DeLand; J R van Nagell; N Javadpour
Journal:  Science       Date:  1980-06-13       Impact factor: 47.728

6.  Preparation and properties of mouse monoclonal antibody (W14A) to human chorionic gonadotropin.

Authors:  F Searle; C S Partridge; A Kardana; A J Green; R G Buckley; R H Begent; G A Rawlins
Journal:  Int J Cancer       Date:  1984-04-15       Impact factor: 7.396

7.  The preparation and labeling of DTPA-coupled albumin.

Authors:  D J Hnatowich; W W Layne; R L Childs
Journal:  Int J Appl Radiat Isot       Date:  1982-05

8.  Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions.

Authors:  C F Meares; M J McCall; D T Reardan; D A Goodwin; C I Diamanti; M McTigue
Journal:  Anal Biochem       Date:  1984-10       Impact factor: 3.365

9.  Immunoreactivity and biodistribution of indium-111-labeled monoclonal antibody to a human high molecular weight-melanoma associated antigen.

Authors:  R A Fawwaz; T S Wang; A Estabrook; J M Rosen; M A Hardy; P O Alderson; S C Srivastava; P Richards; S Ferrone
Journal:  J Nucl Med       Date:  1985-05       Impact factor: 10.057

10.  Improved tumour localisation using indium-111 labelled antibodies.

Authors:  D S Fairweather; A R Bradwell; P W Dykes; A T Vaughan; S F Watson-James; S Chandler
Journal:  Br Med J (Clin Res Ed)       Date:  1983-07-16
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  1 in total

1.  Antibody imaging to locate a placental site trophoblastic tumour following a complete hydatidiform mole.

Authors:  R S Heyderman; R H Begent; R G Buckley; F Searle; P Southall; K D Bagshawe
Journal:  J R Soc Med       Date:  1989-05       Impact factor: 18.000
  1 in total

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