Literature DB >> 6538552

Preparation and properties of mouse monoclonal antibody (W14A) to human chorionic gonadotropin.

F Searle, C S Partridge, A Kardana, A J Green, R G Buckley, R H Begent, G A Rawlins.   

Abstract

A mouse monoclonal antibody, W14A, has been prepared which reacts with intact human chorionic gonadotropin and its beta-subunit, showing less than 2% cross-reactivity towards the alpha-subunit and 0.5% cross-reactivity towards the beta-subunit of luteinizing hormone. The reagent is suitable for the radioimmunolocalization of choriocarcinoma and trophoblastic teratoma in humans. A preliminary radioimmunoassay has been developed.

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Year:  1984        PMID： 6538552     DOI： 10.1002/ijc.2910330402

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  9 in total

1.  A comparative distribution study of 111In-labeled DTPA and TTHA monoclonal antibody conjugates in a choriocarcinoma xenograft model.

Authors:  R G Buckley; P Barnett; F Searle; R Pedley; J A Boden
Journal:  Eur J Nucl Med       Date:  1986

2.  Second antibody for improvement of antibody imaging: liposome-entrapped and free preparations in animal and human studies.

Authors:  H J Begent; K A Chester; K D Bagshawe; P A Keep; F Searle; J Boden; G M Barratt; A J Green; S J Riggs; D F Woodrow
Journal:  Clin Exp Immunol       Date:  1989-11       Impact factor: 4.330

3.  Distribution of intact and Fab2(1) fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts.

Authors:  F Searle; T Adam; J A Boden
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

4.  The potential of carboxypeptidase G2: antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model.

Authors:  R G Melton; F Searle; R F Sherwood; K D Bagshawe; J A Boden
Journal:  Br J Cancer       Date:  1990-03       Impact factor: 7.640

5.  Cyclosporin A prevents the anti-murine antibody response to a monoclonal anti-tumour antibody in rabbits.

Authors:  J A Ledermann; R H Begent; K D Bagshawe
Journal:  Br J Cancer       Date:  1988-11       Impact factor: 7.640

6.  A cytotoxic agent can be generated selectively at cancer sites.

Authors:  K D Bagshawe; C J Springer; F Searle; P Antoniw; S K Sharma; R G Melton; R F Sherwood
Journal:  Br J Cancer       Date:  1988-12       Impact factor: 7.640

7.  Characterisation of UGP and its relationship with beta-core fragment.

Authors:  A Kardana; K D Bagshawe; B Coles; D Read; M Taylor
Journal:  Br J Cancer       Date:  1993-04       Impact factor: 7.640

8.  The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma.

Authors:  R H Begent; K D Bagshawe; A J Green; F Searle
Journal:  Br J Cancer       Date:  1987-06       Impact factor: 7.640

9.  The potential of carboxypeptidase G2-antibody conjugates as anti-tumour agents. I. Preparation of antihuman chorionic gonadotrophin-carboxypeptidase G2 and cytotoxicity of the conjugate against JAR choriocarcinoma cells in vitro.

Authors:  F Searle; C Bier; R G Buckley; S Newman; R B Pedley; K D Bagshawe; R G Melton; S M Alwan; R F Sherwood
Journal:  Br J Cancer       Date:  1986-03       Impact factor: 7.640
  9 in total

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