Literature DB >> 7241469

Radioimmunolocalization of tumours by external scintigraphy after administration of 131I antibody to human chorionic gonadotrophin: preliminary communication.

R H Begent, F Searle, G Stanway, R F Jewkes, B E Jones, P Vernon, K D Bagshawe.   

Abstract

(131)Iodine ((131)I) labelled antibody directed against human chorionic gonadatrophin (hCG) was given on 21 occasions to 18 patients with hCG-producing neoplasms. Tumours were localized by external scintigraphy in 13 of 21 investigations. Positive results were obtained reliably when serum hCG exceeded 500 miu/ml and in some cases sensitivity was comparable to that of computerized tomography. A positive result probably implies viability in the tumour and this was of practical value in discriminating between necrotic deposits and living tumour before surgery.

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Year:  1980        PMID： 7241469      PMCID： PMC1438203          DOI： 10.1177/014107688007300905

Source DB:  PubMed          Journal:  J R Soc Med        ISSN： 0141-0768            Impact factor:   5.344


  7 in total

1.  A rapid, sensitive and specific radioimmunoassay for human chorionic gonadotrophin.

Authors:  A Kardana; K D Bagshawe
Journal:  J Immunol Methods       Date:  1976       Impact factor: 2.303

2.  A method of trace iodination of proteins for immunologic studies.

Authors:  P J McConahey; F J Dixon
Journal:  Int Arch Allergy Appl Immunol       Date:  1966

3.  In vivo localisation of radiolabelled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice.

Authors:  J P Mach; S Carrel; C Merenda; B Sordat; J C Cerottini
Journal:  Nature       Date:  1974-04-19       Impact factor: 49.962

4.  Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning.

Authors:  D M Goldenberg; F DeLand; E Kim; S Bennett; F J Primus; J R van Nagell; N Estes; P DeSimone; P Rayburn
Journal:  N Engl J Med       Date:  1978-06-22       Impact factor: 91.245

5.  Localisation of tumour deposits by external scanning after injection of radiolabelled anti-carcinoembryonic antigen.

Authors:  P W Dykes; K R Hine; A R Bradwell; J C Blackburn; T A Reeder; Z Drolc; S N Booth
Journal:  Br Med J       Date:  1980-01-26

6.  Tumor localization of radiolabeled antibodies against carcinoembryonic antigen in patients with carcinoma: a critical evaluation.

Authors:  J P Mach; S Carrel; M Forni; J Ritschard; A Donath; P Alberto
Journal:  N Engl J Med       Date:  1980-07-03       Impact factor: 91.245

7.  Localization of GW-39 human tumors in hamsters by affinity-purified antibody to carcinoembryonic antigen.

Authors:  F J Primus; R Macdonald; D M Goldenberg; H J Hansen
Journal:  Cancer Res       Date:  1977-05       Impact factor: 12.701
  7 in total
  11 in total

1.  A comparative distribution study of 111In-labeled DTPA and TTHA monoclonal antibody conjugates in a choriocarcinoma xenograft model.

Authors:  R G Buckley; P Barnett; F Searle; R Pedley; J A Boden
Journal:  Eur J Nucl Med       Date:  1986

Review 2.  Antibody-directed enzyme prodrug therapy.

Authors:  K D Bagshawe
Journal:  Clin Pharmacokinet       Date:  1994-11       Impact factor: 6.447

3.  Is there a role for radioimmunolocalization in diagnosis of intracranial malignancies?: discussion paper.

Authors:  J T Kemshead; D H Jones; A Goldman; R B Richardson; H B Coakham
Journal:  J R Soc Med       Date:  1984-10       Impact factor: 5.344

4.  Use of specific antibody for rapid clearance of circulating blood background from radiolabeled tumor imaging proteins.

Authors:  D Goodwin; C Meares; C Diamanti; M McCall; C Lai; F Torti; M McTigue; B Martin
Journal:  Eur J Nucl Med       Date:  1984

5.  Radioimmunolocalization of human brain tumours: biodistribution of radiolabelled monoclonal antibody UJ13A.

Authors:  R B Richardson; A G Davies; S P Bourne; G E Staddon; D H Jones; J T Kemshead; H B Coakham
Journal:  Eur J Nucl Med       Date:  1986

Review 6.  Imaging in targeted delivery of therapy to cancer.

Authors:  Gairin Dancey; Richard H Begent; Tim Meyer
Journal:  Target Oncol       Date:  2009-10-08       Impact factor: 4.493

Review 7.  The First Bagshawe lecture. Towards generating cytotoxic agents at cancer sites.

Authors:  K D Bagshawe
Journal:  Br J Cancer       Date:  1989-09       Impact factor: 7.640

Review 8.  Scanning for tumours with radiolabelled antibodies: a review.

Authors:  P W Dykes; A R Bradwell; D S Fairweather
Journal:  J R Soc Med       Date:  1983-11       Impact factor: 18.000

9.  The clinical value of imaging with antibody to human chorionic gonadotrophin in the detection of residual choriocarcinoma.

Authors:  R H Begent; K D Bagshawe; A J Green; F Searle
Journal:  Br J Cancer       Date:  1987-06       Impact factor: 7.640

10.  A human choriocarcinoma xenograft in nude mice; a model for the study of antibody localization.

Authors:  F Searle; J Boden; J C Lewis; K D Bagshawe
Journal:  Br J Cancer       Date:  1981-08       Impact factor: 7.640
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