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Literature DB >> 3095842

A repetitive antigen of Plasmodium falciparum that is homologous to heat shock protein 70 of Drosophila melanogaster.

A E Bianco, J M Favaloro, T R Burkot, J G Culvenor, P E Crewther, G V Brown, R F Anders, R L Coppel, D J Kemp.

Abstract

We describe an antigen of Plasmodium falciparum, defined by a cDNA clone designated Ag63. The antigen is an abundant, soluble cytoplasmic polypeptide of Mr 75,000 present in all stages of asexual development in the blood and in gametocytes, but not in sporozoites. The sequence of the cDNA clone revealed that, like many other antigens of P. falciparum, it contains tandemly repeated amino acid sequences, in this case Gly-Gly-Met-Pro. However, the rest of the sequence is 70% homologous at the amino acid level to the heat shock protein hsp70 of Drosophila melanogaster.

Entities: Chemical Species

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Year: 1986 PMID： 3095842 PMCID： PMC387001 DOI： 10.1073/pnas.83.22.8713

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

1. Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids.

Authors: R L Coppel; A F Cowman; K R Lingelbach; G V Brown; R B Saint; D J Kemp; R F Anders
Journal: Nature Date: 1983 Dec 22-1984 Jan 4 Impact factor: 49.962

2. A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.

Authors: J Messing; J Vieira
Journal: Gene Date: 1982-10 Impact factor: 3.688

3. Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions.

Authors: T D Ingolia; E A Craig; B J McCarthy
Journal: Cell Date: 1980-10 Impact factor: 41.582

4. Establishing homologies in protein sequences.

Authors: M O Dayhoff; W C Barker; L T Hunt
Journal: Methods Enzymol Date: 1983 Impact factor: 1.600

5. Radioiodination of new protein antigens on the surface of Plasmodium knowlesi schizont-infected erythrocytes.

Authors: R J Howard; J W Barnwell; V Kao; W A Daniel; S B Aley
Journal: Mol Biochem Parasitol Date: 1982-12 Impact factor: 1.759

6. Saccharomyces cerevisiae contains a complex multigene family related to the major heat shock-inducible gene of Drosophila.

Authors: T D Ingolia; M R Slater; E A Craig
Journal: Mol Cell Biol Date: 1982-11 Impact factor: 4.272

7. Identification and chemical synthesis of a tandemly repeated immunogenic region of Plasmodium knowlesi circumsporozoite protein.

Authors: G N Godson; J Ellis; P Svec; D H Schlesinger; V Nussenzweig
Journal: Nature Date: 1983 Sep 1-7 Impact factor: 49.962

8. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

9. Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock.

Authors: T D Ingolia; E A Craig
Journal: Proc Natl Acad Sci U S A Date: 1982-01 Impact factor: 11.205

10. Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans.

Authors: D J Kemp; R L Coppel; A F Cowman; R B Saint; G V Brown; R F Anders
Journal: Proc Natl Acad Sci U S A Date: 1983-06 Impact factor: 11.205

42 in total

9. Correct promoter control is needed for trafficking of the ring-infected erythrocyte surface antigen to the host cytosol in transfected malaria parasites.

Authors: Melanie Rug; Mark E Wickham; Michael Foley; Alan F Cowman; Leann Tilley
Journal: Infect Immun Date: 2004-10 Impact factor: 3.441

10. Evidence for epitope-specific thymus-independent response against a repeat sequence in a protein antigen.

Authors: N Kumar; H Zheng
Journal: Immunology Date: 1998-05 Impact factor: 7.397

A repetitive antigen of Plasmodium falciparum that is homologous to heat shock protein 70 of Drosophila melanogaster.

1. Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids.

2. A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments.

3. Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions.

4. Establishing homologies in protein sequences.

5. Radioiodination of new protein antigens on the surface of Plasmodium knowlesi schizont-infected erythrocytes.

6. Saccharomyces cerevisiae contains a complex multigene family related to the major heat shock-inducible gene of Drosophila.

7. Identification and chemical synthesis of a tandemly repeated immunogenic region of Plasmodium knowlesi circumsporozoite protein.

8. DNA sequencing with chain-terminating inhibitors.

9. Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock.

10. Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans.

1. Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites.

2. The sequence of a third member of the heat shock protein family in Plasmodium falciparum.

Review 3. Parasite heat-shock proteins and host responses: the balance between protection and immunopathology.

Review 4. The heat shock protein response and its role in inflammatory disease.

5. Plasmodium falciparum gene encoding a protein similar to the 78-kDa rat glucose-regulated stress protein.

6. A protein antigen of Mycobacterium leprae is related to a family of small heat shock proteins.

7. Identification of a heat shock-like antigen in P. falciparum, related to the heat shock protein 90 family.

Review 8. Stress proteins and the immune response to mycobacteria--antigens as virulence factors?

9. Correct promoter control is needed for trafficking of the ring-infected erythrocyte surface antigen to the host cytosol in transfected malaria parasites.

10. Evidence for epitope-specific thymus-independent response against a repeat sequence in a protein antigen.