Literature DB >> 12228305

Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites.

Julie Healer1, Simon Crawford, Stuart Ralph, Geoff McFadden, Alan F Cowman.   

Abstract

Apical membrane antigen 1 of Plasmodium falciparum (PfAMA1) contains an N-terminal propeptide that is removed prior to the translocation of the mature protein onto the merozoite surface. We localized unprocessed PfAMA1 to the microneme organelles of the intraerythrocytic schizont. The results have suggested that the processed form of PfAMA1 translocates from the microneme compartment independently of another microneme protein, EBA175, which is also involved in the invasion of human erythrocytes.

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Year:  2002        PMID： 12228305      PMCID： PMC128307          DOI： 10.1128/IAI.70.10.5751-5758.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  43 in total

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Authors:  B Striepen; D Soldati; N Garcia-Reguet; J F Dubremetz; D S Roos
Journal:  Mol Biochem Parasitol       Date:  2001-03       Impact factor: 1.759

2.  The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases.

Authors:  V B Carruthers; G D Sherman; L D Sibley
Journal:  J Biol Chem       Date:  2000-05-12       Impact factor: 5.157

3.  RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum.

Authors:  D L Baldi; K T Andrews; R F Waller; D S Roos; R F Howard; B S Crabb; A F Cowman
Journal:  EMBO J       Date:  2000-06-01       Impact factor: 11.598

4.  Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species.

Authors:  T Triglia; J Healer; S R Caruana; A N Hodder; R F Anders; B S Crabb; A F Cowman
Journal:  Mol Microbiol       Date:  2000-11       Impact factor: 3.501

Review 5.  Malaria vaccines.

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Journal:  Parasitol Today       Date:  2000-10

6.  Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii.

Authors:  S D Brydges; G D Sherman; S Nockemann; A Loyens; W Däubener; J F Dubremetz; V B Carruthers
Journal:  Mol Biochem Parasitol       Date:  2000-11       Impact factor: 1.759

7.  The Toxoplasma homolog of Plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels.

Authors:  C G Donahue; V B Carruthers; S D Gilk; G E Ward
Journal:  Mol Biochem Parasitol       Date:  2000-11       Impact factor: 1.759

8.  Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion.

Authors:  M B Reed; S R Caruana; A H Batchelor; J K Thompson; B S Crabb; A F Cowman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

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Authors:  C H Kocken; A M van der Wel; M A Dubbeld; D L Narum; F M van de Rijke; G J van Gemert; X van der Linde; L H Bannister; C Janse; A P Waters; A W Thomas
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10.  Identification and characterization of an escorter for two secretory adhesins in Toxoplasma gondii.

Authors:  M Reiss; N Viebig; S Brecht; M N Fourmaux; M Soete; M Di Cristina ; J F Dubremetz; D Soldati
Journal:  J Cell Biol       Date:  2001-02-05       Impact factor: 10.539
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  65 in total

1.  Identification, cloning, expression, and characterization of the gene for Plasmodium knowlesi surface protein containing an altered thrombospondin repeat domain.

Authors:  Babita Mahajan; Dewal Jani; Rana Chattopadhyay; Rana Nagarkatti; Hong Zheng; Victoria Majam; Walter Weiss; Sanjai Kumar; Dharmendar Rathore
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

2.  Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparum.

Authors:  Sheetij Dutta; J David Haynes; Arnoldo Barbosa; Lisa A Ware; Jeffrey D Snavely; J Kathleen Moch; Alan W Thomas; David E Lanar
Journal:  Infect Immun       Date:  2005-04       Impact factor: 3.441

3.  Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1.

Authors:  Karen S Harris; Joanne L Casey; Andrew M Coley; Rosella Masciantonio; Jennifer K Sabo; David W Keizer; Erinna F Lee; Andrew McMahon; Raymond S Norton; Robin F Anders; Michael Foley
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

4.  Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine design.

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Journal:  Proc Natl Acad Sci U S A       Date:  2008-05-30       Impact factor: 11.205

5.  Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion.

Authors:  Prakash Srinivasan; Wandy L Beatty; Ababacar Diouf; Raul Herrera; Xavier Ambroggio; J Kathleen Moch; Jessica S Tyler; David L Narum; Susan K Pierce; John C Boothroyd; J David Haynes; Louis H Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-25       Impact factor: 11.205

6.  Apical membrane antigen 1, a major malaria vaccine candidate, mediates the close attachment of invasive merozoites to host red blood cells.

Authors:  G H Mitchell; A W Thomas; G Margos; A R Dluzewski; L H Bannister
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

7.  Advances and challenges in malaria vaccine development.

Authors:  Ruobing Wang; Joseph D Smith; Stefan H I Kappe
Journal:  Expert Rev Mol Med       Date:  2009-12-16       Impact factor: 5.600

8.  Correct promoter control is needed for trafficking of the ring-infected erythrocyte surface antigen to the host cytosol in transfected malaria parasites.

Authors:  Melanie Rug; Mark E Wickham; Michael Foley; Alan F Cowman; Leann Tilley
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

9.  Do apicomplexan parasite-encoded proteins act as both ligands and receptors during host cell invasion?

Authors:  Paul R Gilson; Brendan S Crabb
Journal:  F1000 Biol Rep       Date:  2009-08-26

10.  Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.

Authors:  Kwadwo A Kusi; Bart W Faber; Alan W Thomas; Edmond J Remarque
Journal:  PLoS One       Date:  2009-12-01       Impact factor: 3.240
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