| Literature DB >> 30936118 |
Tony Taldone1, Tai Wang1, Anna Rodina1, Naga Vara Kishore Pillarsetty2, Chander S Digwal1, Sahil Sharma1, Pengrong Yan1, Suhasini Joshi1, Piyusha P Pagare1, Alexander Bolaender1, Gail J Roboz3, Monica L Guzman3, Gabriela Chiosis1,4.
Abstract
Cancer is often associated with alterations in the chaperome, a collection of chaperones, cochaperones, and other cofactors. Changes in the expression levels of components of the chaperome, in the interaction strength among chaperome components, alterations in chaperome constituency, and in the cellular location of chaperome members, are all hallmarks of cancer. Here we aim to provide an overview on how chemical biology has played a role in deciphering such complexity in the biology of the chaperome in cancer and in other diseases. The focus here is narrow and on pathologic changes in the chaperome executed by enhancing the interaction strength between components of distinct chaperome pathways, specifically between those of HSP90 and HSP70 pathways. We will review chemical tools and chemical probe-based assays, with a focus on HSP90. We will discuss how kinetic binding, not classical equilibrium binding, is most appropriate in the development of drugs and probes for the chaperome in disease. We will then present our view on how chaperome inhibitors may become potential drugs and diagnostics in cancer.Entities:
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Year: 2020 PMID： 30936118 PMCID： PMC6773535 DOI： 10.1101/cshperspect.a034116
Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005