| Literature DB >> 32191434 |
Dany Pechalrieu1, Fanny Assemat1, Ludovic Halby1,2, Marlene Marcellin3, Pengrong Yan4, Karima Chaoui3, Sahil Sharma4, Gabriela Chiosis4, Odile Burlet-Schiltz3, Paola B Arimondo1,2, Marie Lopez1,5.
Abstract
We synthesized affinity-based chemical probes of cytosine-adenosine bisubstrate analogs and identified several potential targets by proteomic analysis. The validation of the proteomic analysis identified the chemical probe as a specific inhibitor of glucose-regulated protein 94 (GRP94), a potential drug target for several types of cancers. Therefore, as a result of the use of bisubstrate-type chemical probes and a chemical-biology methodology, this work opens the way to the development of a new family of GRP94 inhibitors that could potentially be of therapeutic interest.Entities:
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Year: 2020 PMID： 32191434 PMCID： PMC7336334 DOI： 10.1021/acschembio.9b00965
Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100