Literature DB >> 30924239

SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism.

Sam Benson1, Antonio Fernandez1, Nicole D Barth1, Fabio de Moliner1, Mathew H Horrocks2, C Simon Herrington3, Jose Luis Abad4,5, Antonio Delgado4,5, Lisa Kelly1, Ziyuan Chang1, Yi Feng1, Miyako Nishiura6, Yuichiro Hori6, Kazuya Kikuchi6, Marc Vendrell1.   

Abstract

The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein, we describe SCOTfluors as novel small-sized multi-colored fluorophores for real-time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.
© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Entities:  

Keywords:  cancer; fluorescence; imaging agents; metabolites; super-resolution imaging

Mesh：

Substances：

Year:  2019        PMID： 30924239      PMCID： PMC6563150          DOI： 10.1002/anie.201900465

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  30 in total

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2.  The Synthesis and Photophysical Analysis of a Series of 4-Nitrobenzochalcogenadiazoles for Super-Resolution Microscopy.

Authors:  Daniel Ray Jenkinson; Ashley James Cadby; Simon Jones
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3.  A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies.

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Journal:  Chem Commun (Camb)       Date:  2017-01-10       Impact factor: 6.222

4.  7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: a new fluorigenic reagent for amino acids and other amines.

Authors:  P B Ghosh; M W Whitehouse
Journal:  Biochem J       Date:  1968-06       Impact factor: 3.857

5.  Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride.

Authors:  Nicola Kielland; Marc Vendrell; Rodolfo Lavilla; Young-Tae Chang
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6.  A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host Cells.

Authors:  Leon N Schulte; Benedikt Heinrich; Harshavardhan Janga; Bernd T Schmeck; Olalla Vázquez
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-06       Impact factor: 15.336

7.  Development of background-free tame fluorescent probes for intracellular live cell imaging.

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Journal:  Nat Commun       Date:  2016-06-20       Impact factor: 14.919

Review 8.  Modern Synthetic Avenues for the Preparation of Functional Fluorophores.

Authors:  Fabio de Moliner; Nicola Kielland; Rodolfo Lavilla; Marc Vendrell
Journal:  Angew Chem Int Ed Engl       Date:  2017-02-17       Impact factor: 15.336

9.  Tuning the Color Palette of Fluorescent Copper Sensors through Systematic Heteroatom Substitution at Rhodol Cores.

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10.  Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue.

Authors:  Lorena Mendive-Tapia; Can Zhao; Ahsan R Akram; Sara Preciado; Fernando Albericio; Martin Lee; Alan Serrels; Nicola Kielland; Nick D Read; Rodolfo Lavilla; Marc Vendrell
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  24 in total

1.  SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism.

Authors:  Sam Benson; Antonio Fernandez; Nicole D Barth; Fabio de Moliner; Mathew H Horrocks; C Simon Herrington; Jose Luis Abad; Antonio Delgado; Lisa Kelly; Ziyuan Chang; Yi Feng; Miyako Nishiura; Yuichiro Hori; Kazuya Kikuchi; Marc Vendrell
Journal:  Angew Chem Int Ed Engl       Date:  2019-04-12       Impact factor: 15.336

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Journal:  J Phys Chem Lett       Date:  2021-10-15       Impact factor: 6.475

Review 3.  Single cell metabolism: current and future trends.

Authors:  Ahmed Ali; Shawn Davidson; Ernest Fraenkel; Ian Gilmore; Thomas Hankemeier; Jennifer A Kirwan; Andrew N Lane; Ingela Lanekoff; Mioara Larion; Laura-Isobel McCall; Michael Murphy; Jonathan V Sweedler; Caigang Zhu
Journal:  Metabolomics       Date:  2022-10-01       Impact factor: 4.747

4.  Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates.

Authors:  Pascal Poc; Vanessa A Gutzeit; Julia Ast; Joon Lee; Ben J Jones; Elisa D'Este; Bettina Mathes; Martin Lehmann; David J Hodson; Joshua Levitz; Johannes Broichhagen
Journal:  Chem Sci       Date:  2020-07-07       Impact factor: 9.825

5.  Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging.

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Review 6.  Activatable Fluorophores for Imaging Immune Cell Function.

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Journal:  Acc Chem Res       Date:  2022-04-05       Impact factor: 24.466

Review 7.  The frontier of live tissue imaging across space and time.

Authors:  Qiang Huang; Aliesha Garrett; Shree Bose; Stephanie Blocker; Anne C Rios; Hans Clevers; Xiling Shen
Journal:  Cell Stem Cell       Date:  2021-04-01       Impact factor: 24.633

8.  A new pentacyclic pyrylium fluorescent probe that responds to pH imbalance during apoptosis.

Authors:  Sandip Chakraborty; Manu M Joseph; Sunil Varughese; Samrat Ghosh; Kaustabh K Maiti; Animesh Samanta; Ayyappanpillai Ajayaghosh
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Review 9.  Near-infrared fluorescent probes: a next-generation tool for protein-labeling applications.

Authors:  Shahi Imam Reja; Masafumi Minoshima; Yuichiro Hori; Kazuya Kikuchi
Journal:  Chem Sci       Date:  2020-10-23       Impact factor: 9.825

Review 10.  NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications.

Authors:  Chenyang Jiang; Haojie Huang; Xueying Kang; Liu Yang; Zhen Xi; Hongyan Sun; Michael D Pluth; Long Yi
Journal:  Chem Soc Rev       Date:  2021-07-05       Impact factor: 60.615
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