Literature DB >> 30905345

Phospholipase A2 catalysis and lipid mediator lipidomics.

Varnavas D Mouchlis1, Edward A Dennis2.   

Abstract

Phospholipase A2 (PLA2) enzymes are the upstream regulators of the eicosanoid pathway liberating free arachidonic acid from the sn-2 position of membrane phospholipids. Free intracellular arachidonic acid serves as a substrate for the eicosanoid biosynthetic enzymes including cyclooxygenases, lipoxygenases, and cytochrome P450s that lead to inflammation. The Group IVA cytosolic (cPLA2), Group VIA calcium-independent (iPLA2), and Group V secreted (sPLA2) are three well-characterized human enzymes that have been implicated in eicosanoid formation. In this review, we will introduce and summarize the regulation of catalytic activity and cellular localization, structural characteristics, interfacial activation and kinetics, substrate specificity, inhibitor binding and interactions, and the downstream implications for eicosanoid biosynthesis of these three important PLA2 enzymes.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Catalytic mechanism; HD-XMS; LC/MS assays; Molecular dynamics; Phospholipase; Substrate specificity

Mesh：

Substances：

Year:  2018        PMID： 30905345      PMCID： PMC6483111          DOI： 10.1016/j.bbalip.2018.08.010

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Cell Biol Lipids        ISSN： 1388-1981            Impact factor:   4.698


  67 in total

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Review 2.  Regulation of arachidonic acid release and cytosolic phospholipase A2 activation.

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Review 3.  Eicosanoid storm in infection and inflammation.

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Authors:  Jian Cao; John E Burke; Edward A Dennis
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8.  Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism.

Authors:  A Dessen; J Tang; H Schmidt; M Stahl; J D Clark; J Seehra; W S Somers
Journal:  Cell       Date:  1999-04-30       Impact factor: 41.582

9.  Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum.

Authors:  A R Schievella; M K Regier; W L Smith; L L Lin
Journal:  J Biol Chem       Date:  1995-12-22       Impact factor: 5.157

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6.  Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A2 inhibitors.

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Review 7.  Redox phospholipidomics of enzymatically generated oxygenated phospholipids as specific signals of programmed cell death.

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8.  Purification of Cytosolic Phospholipase A2α C2-domain after Expression in Soluble Form in Escherichia coli.

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