| Literature DB >> 30893588 |
Anubhav N Mathur1, Bahar Zirak1, Ian C Boothby1, Madge Tan1, Jarish N Cohen1, Thea M Mauro1, Pooja Mehta1, Margaret M Lowe1, Abul K Abbas2, Niwa Ali1, Michael D Rosenblum3.
Abstract
Restoration of barrier-tissue integrity after injury is dependent on the function of immune cells and stem cells (SCs) residing in the tissue. In response to skin injury, hair-follicle stem cells (HFSCs), normally poised for hair generation, are recruited to the site of injury and differentiate into cells that repair damaged epithelium. We used a SC fate-mapping approach to examine the contribution of regulatory T (Treg) cells to epidermal-barrier repair after injury. Depletion of Treg cells impaired skin-barrier regeneration and was associated with a Th17 inflammatory response and failed HFSC differentiation. In this setting, damaged epithelial cells preferentially expressed the neutrophil chemoattractant CXCL5, and blockade of CXCL5 or neutrophil depletion restored barrier function and SC differentiation after epidermal injury. Thus, Treg-cell regulation of localized inflammation enables HFSC differentiation and, thereby, skin-barrier regeneration, with implications for the maintenance and repair of other barrier tissues.Entities:
Keywords: CXCL5; IL-17; Lrg5; barrier repair; epidermis; hair follicle stem cells; regulatory T cell (Treg); skin; stem cell
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Year: 2019 PMID： 30893588 PMCID： PMC6507428 DOI： 10.1016/j.immuni.2019.02.013
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745