Literature DB >> 31607562

Roles of Regulatory T Cells in Tissue Pathophysiology and Metabolism.

Clarissa Campbell1, Alexander Rudensky2.   

Abstract

Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  metabolism; regulatory T cells; tissue homeostasis

Mesh：

Substances：

Year:  2019        PMID： 31607562      PMCID： PMC7657366          DOI： 10.1016/j.cmet.2019.09.010

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  78 in total

1.  Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.

Authors:  Hironori Ueda; Joanna M M Howson; Laura Esposito; Joanne Heward; Hywel Snook; Giselle Chamberlain; Daniel B Rainbow; Kara M D Hunter; Annabel N Smith; Gianfranco Di Genova; Mathias H Herr; Ingrid Dahlman; Felicity Payne; Deborah Smyth; Christopher Lowe; Rebecca C J Twells; Sarah Howlett; Barry Healy; Sarah Nutland; Helen E Rance; Vin Everett; Luc J Smink; Alex C Lam; Heather J Cordell; Neil M Walker; Cristina Bordin; John Hulme; Costantino Motzo; Francesco Cucca; J Fred Hess; Michael L Metzker; Jane Rogers; Simon Gregory; Amit Allahabadia; Ratnasingam Nithiyananthan; Eva Tuomilehto-Wolf; Jaakko Tuomilehto; Polly Bingley; Kathleen M Gillespie; Dag E Undlien; Kjersti S Rønningen; Cristian Guja; Constantin Ionescu-Tîrgovişte; David A Savage; A Peter Maxwell; Dennis J Carson; Chris C Patterson; Jayne A Franklyn; David G Clayton; Laurence B Peterson; Linda S Wicker; John A Todd; Stephen C L Gough
Journal:  Nature       Date:  2003-04-30       Impact factor: 49.962

2.  T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.

Authors:  Moshe Biton; Adam L Haber; Noga Rogel; Grace Burgin; Semir Beyaz; Alexandra Schnell; Orr Ashenberg; Chien-Wen Su; Christopher Smillie; Karthik Shekhar; Zuojia Chen; Chuan Wu; Jose Ordovas-Montanes; David Alvarez; Rebecca H Herbst; Mei Zhang; Itay Tirosh; Danielle Dionne; Lan T Nguyen; Michael E Xifaras; Alex K Shalek; Ulrich H von Andrian; Daniel B Graham; Orit Rozenblatt-Rosen; Hai Ning Shi; Vijay Kuchroo; Omer H Yilmaz; Aviv Regev; Ramnik J Xavier
Journal:  Cell       Date:  2018-11-01       Impact factor: 41.582

3.  MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells.

Authors:  Caspar Ohnmacht; Joo-Hong Park; Sascha Cording; James B Wing; Koji Atarashi; Yuuki Obata; Valérie Gaboriau-Routhiau; Rute Marques; Sophie Dulauroy; Maria Fedoseeva; Meinrad Busslinger; Nadine Cerf-Bensussan; Ivo G Boneca; David Voehringer; Koji Hase; Kenya Honda; Shimon Sakaguchi; Gérard Eberl
Journal:  Science       Date:  2015-07-09       Impact factor: 47.728

4.  Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33.

Authors:  T Mahlakõiv; A-L Flamar; L K Johnston; S Moriyama; G G Putzel; P J Bryce; D Artis
Journal:  Sci Immunol       Date:  2019-05-03

5.  Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

Authors:  Yuri P Rubtsov; Jeffrey P Rasmussen; Emil Y Chi; Jason Fontenot; Luca Castelli; Xin Ye; Piper Treuting; Lisa Siewe; Axel Roers; William R Henderson; Werner Muller; Alexander Y Rudensky
Journal:  Immunity       Date:  2008-04       Impact factor: 31.745

6.  CTLA-4 control over Foxp3+ regulatory T cell function.

Authors:  Kajsa Wing; Yasushi Onishi; Paz Prieto-Martin; Tomoyuki Yamaguchi; Makoto Miyara; Zoltan Fehervari; Takashi Nomura; Shimon Sakaguchi
Journal:  Science       Date:  2008-10-10       Impact factor: 47.728

7.  A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.

Authors:  Hyang-Mi Lee; Jhoanne L Bautista; James Scott-Browne; James F Mohan; Chyi-Song Hsieh
Journal:  Immunity       Date:  2012-08-23       Impact factor: 31.745

8.  Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

Authors:  Giovanna Borsellino; Markus Kleinewietfeld; Diletta Di Mitri; Alexander Sternjak; Adamo Diamantini; Raffaella Giometto; Sabine Höpner; Diego Centonze; Giorgio Bernardi; Maria Luisa Dell'Acqua; Paolo Maria Rossini; Luca Battistini; Olaf Rötzschke; Kirsten Falk
Journal:  Blood       Date:  2007-04-20       Impact factor: 22.113

9.  Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.

Authors:  Arthur Liesz; Elisabeth Suri-Payer; Claudia Veltkamp; Henrike Doerr; Clemens Sommer; Serge Rivest; Thomas Giese; Roland Veltkamp
Journal:  Nat Med       Date:  2009-01-25       Impact factor: 53.440

10.  Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.

Authors:  Ari B Molofsky; Frédéric Van Gool; Hong-Erh Liang; Steven J Van Dyken; Jesse C Nussbaum; Jinwoo Lee; Jeffrey A Bluestone; Richard M Locksley
Journal:  Immunity       Date:  2015-06-16       Impact factor: 31.745
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  31 in total

Review 1.  Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3+ regulatory T cells.

Authors:  Mark D Mannie; Kayla B DeOca; Alexander G Bastian; Cody D Moorman
Journal:  Cell Immunol       Date:  2020-07-15       Impact factor: 4.868

2.  Monocytes maintain central nervous system homeostasis following helminth-induced inflammation.

Authors:  Jianya Peng; Chandler B Sy; John J Ponessa; Alexander D Lemenze; Christina M Hernandez; Juan M Inclan-Rico; Arman Sawhney; Hannah G Federman; Krupa Chavan; Vanessa Espinosa; Sergei V Kotenko; Amariliz Rivera; Mark C Siracusa
Journal:  Proc Natl Acad Sci U S A       Date:  2022-09-07       Impact factor: 12.779

Review 3.  Maternal and fetal T cells in term pregnancy and preterm labor.

Authors:  Derek Miller; Meyer Gershater; Rebecca Slutsky; Roberto Romero; Nardhy Gomez-Lopez
Journal:  Cell Mol Immunol       Date:  2020-05-28       Impact factor: 11.530

4.  Host Cxcr2-Dependent Regulation of Pancreatic Cancer Growth, Angiogenesis, and Metastasis.

Authors:  Abhilasha Purohit; Sugandha Saxena; Michelle Varney; Dipakkumar R Prajapati; Jessica A Kozel; Audrey Lazenby; Rakesh K Singh
Journal:  Am J Pathol       Date:  2021-01-14       Impact factor: 4.307

Review 5.  Interleukin-2 and regulatory T cells in rheumatic diseases.

Authors:  Antonios G A Kolios; George C Tsokos; David Klatzmann
Journal:  Nat Rev Rheumatol       Date:  2021-11-02       Impact factor: 20.543

Review 6.  Regulation of Alloantibody Responses.

Authors:  Anita S Chong; Peter T Sage; Maria-Luisa Alegre
Journal:  Front Cell Dev Biol       Date:  2021-07-08

Review 7.  Immune outposts in the adventitia: One foot in sea and one on shore.

Authors:  Kelly M Cautivo; Catherine A Steer; Ari B Molofsky
Journal:  Curr Opin Immunol       Date:  2020-04-24       Impact factor: 7.486

Review 8.  Cellular immune responses in the pathophysiology of preeclampsia.

Authors:  Derek Miller; Kenichiro Motomura; Jose Galaz; Meyer Gershater; Eun D Lee; Roberto Romero; Nardhy Gomez-Lopez
Journal:  J Leukoc Biol       Date:  2021-04-13       Impact factor: 6.011

Review 9.  Transcriptional regulation of Treg homeostasis and functional specification.

Authors:  Ke Wang; Wenxian Fu
Journal:  Cell Mol Life Sci       Date:  2020-04-29       Impact factor: 9.207

Review 10.  Contact dermatitis.

Authors:  Pamela L Scheinman; Marc Vocanson; Jacob P Thyssen; Jeanne Duus Johansen; Rosemary L Nixon; Kate Dear; Nina C Botto; Johanna Morot; Ari M Goldminz
Journal:  Nat Rev Dis Primers       Date:  2021-05-27       Impact factor: 52.329
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