Zhentao Zhou1, Qinyuan Zhao2, Jun Zhao3, Jufang Zhang2. 1. The Fourth Clinical College of Zhejiang Chinese Medicine University, Hangzhou Zhejiang, 310013, P.R.China. 2. Department of Plastic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou Zhejiang, 310006, P.R.China. 3. Nanjing Medical University, Nanjing Jiangsu, 211100, P.R.China.
Abstract
OBJECTIVE: To explore the research progress of hair follicle and related stem cells in scar-free skin healing in recent years. METHODS: The literature related to hair follicle and related stem cells, wound healing, and scar formation in recent years was extensively reviewed and summarized from the aspects of cell function and molecular mechanism. RESULTS: Scar tissue after wound healing treated with hair follicle transplantation and related stem cell therapy is more mild or even without scar formation. The cell types and molecular mechanisms of the above phenomena are complex, and the bone morphogenetic protein signal transduction pathway and Wnt signal transduction pathway are strongly correlated. CONCLUSION: The research of hair follicle and related stem cells in scar-free skin healing is at the initial stage at present. Strengthening the mechanism research may provide new ideas for the treatment of wound and scar.
OBJECTIVE: To explore the research progress of hair follicle and related stem cells in scar-free skin healing in recent years. METHODS: The literature related to hair follicle and related stem cells, wound healing, and scar formation in recent years was extensively reviewed and summarized from the aspects of cell function and molecular mechanism. RESULTS: Scar tissue after wound healing treated with hair follicle transplantation and related stem cell therapy is more mild or even without scar formation. The cell types and molecular mechanisms of the above phenomena are complex, and the bone morphogenetic protein signal transduction pathway and Wnt signal transduction pathway are strongly correlated. CONCLUSION: The research of hair follicle and related stem cells in scar-free skin healing is at the initial stage at present. Strengthening the mechanism research may provide new ideas for the treatment of wound and scar.
Authors: Jun Wei; Denisa Melichian; Kazuhiro Komura; Monique Hinchcliff; Anna P Lam; Robert Lafyatis; Cara J Gottardi; Ormond A MacDougald; John Varga Journal: Arthritis Rheum Date: 2011-06
Authors: Anubhav N Mathur; Bahar Zirak; Ian C Boothby; Madge Tan; Jarish N Cohen; Thea M Mauro; Pooja Mehta; Margaret M Lowe; Abul K Abbas; Niwa Ali; Michael D Rosenblum Journal: Immunity Date: 2019-03-19 Impact factor: 31.745