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Literature DB >> 32358172

Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.

Ian C Boothby^1,2, Jarish N Cohen³, Michael D Rosenblum⁴.

Abstract

Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (Tregs) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of Tregs in facilitating skin repair after injury. We focus on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing and discuss how these interactions are regulated both by "classical" suppressive mechanisms of Tregs and by "nonclassical" reparative Treg functions.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2020 PMID： 32358172 PMCID： PMC7274208 DOI： 10.1126/sciimmunol.aaz9631

Source DB: PubMed Journal: Sci Immunol ISSN： 2470-9468

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