Literature DB >> 30855040

DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA.

Jun Gao1, Alicia K Byrd, Boris L Zybailov, John C Marecki, Michael J Guderyon, Andrea D Edwards, Shubeena Chib, Kirk L West, Zachary J Waldrip, Samuel G Mackintosh, Zhaofeng Gao, Andrea A Putnam, Eckhard Jankowsky, Kevin D Raney.   

Abstract

We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA quadruplexes, suggesting new potential roles for these helicases in disruption of quadruplex structures in RNA.

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Year:  2019        PMID： 30855040      PMCID： PMC6459694          DOI： 10.1039/c8cc10091h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  40 in total

1.  Crystal structure of parallel quadruplexes from human telomeric DNA.

Authors:  Gary N Parkinson; Michael P H Lee; Stephen Neidle
Journal:  Nature       Date:  2002-05-26       Impact factor: 49.962

2.  Ded1p, a conserved DExD/H-box translation factor, can promote yeast L-A virus negative-strand RNA synthesis in vitro.

Authors:  Jean-Leon Chong; Ray-Yuan Chuang; Luh Tung; Tien-Hsien Chang
Journal:  Nucleic Acids Res       Date:  2004-04-02       Impact factor: 16.971

Review 3.  DEAD-box proteins: the driving forces behind RNA metabolism.

Authors:  Sanda Rocak; Patrick Linder
Journal:  Nat Rev Mol Cell Biol       Date:  2004-03       Impact factor: 94.444

4.  The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates.

Authors:  James P Vaughn; Steven D Creacy; Eric D Routh; Christi Joyner-Butt; G Scott Jenkins; Sandra Pauli; Yoshikuni Nagamine; Steven A Akman
Journal:  J Biol Chem       Date:  2005-09-07       Impact factor: 5.157

5.  ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1.

Authors:  Quansheng Yang; Eckhard Jankowsky
Journal:  Biochemistry       Date:  2005-10-18       Impact factor: 3.162

6.  High affinity interactions of nucleolin with G-G-paired rDNA.

Authors:  L A Hanakahi; H Sun; N Maizels
Journal:  J Biol Chem       Date:  1999-05-28       Impact factor: 5.157

7.  Involvement of DEAD-box proteins in group I and group II intron splicing. Biochemical characterization of Mss116p, ATP hydrolysis-dependent and -independent mechanisms, and general RNA chaperone activity.

Authors:  Coralie Halls; Sabine Mohr; Mark Del Campo; Quansheng Yang; Eckhard Jankowsky; Alan M Lambowitz
Journal:  J Mol Biol       Date:  2006-10-03       Impact factor: 5.469

8.  The value of position-specific priors in motif discovery using MEME.

Authors:  Timothy L Bailey; Mikael Bodén; Tom Whitington; Philip Machanick
Journal:  BMC Bioinformatics       Date:  2010-04-09       Impact factor: 3.169

9.  The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies.

Authors:  Carla Beckham; Angela Hilliker; Anne-Marie Cziko; Amine Noueiry; Mani Ramaswami; Roy Parker
Journal:  Mol Biol Cell       Date:  2007-12-27       Impact factor: 4.138

Review 10.  Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases.

Authors:  Eckhard Jankowsky; Heath Bowers
Journal:  Nucleic Acids Res       Date:  2006-08-25       Impact factor: 16.971
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  6 in total

Review 1.  Action and function of helicases on RNA G-quadruplexes.

Authors:  Marco Caterino; Katrin Paeschke
Journal:  Methods       Date:  2021-09-10       Impact factor: 4.647

Review 2.  Emerging molecular functions and novel roles for the DEAD-box protein Dbp5/DDX19 in gene expression.

Authors:  Arvind Arul Nambi Rajan; Ben Montpetit
Journal:  Cell Mol Life Sci       Date:  2020-11-17       Impact factor: 9.261

Review 3.  Transcription, translation, and DNA repair: new insights from emerging noncanonical substrates of RNA helicases.

Authors:  Matthew P Russon; Kirsten M Westerhouse; Elizabeth J Tran
Journal:  Biol Chem       Date:  2020-12-14       Impact factor: 4.700

4.  Active and Passive Destabilization of G-Quadruplex DNA by the Telomere POT1-TPP1 Complex.

Authors:  Mengyuan Xu; Armend Axhemi; Magdalena Malgowska; Yinghua Chen; Daniel Leonard; Sukanya Srinivasan; Eckhard Jankowsky; Derek J Taylor
Journal:  J Mol Biol       Date:  2021-02-04       Impact factor: 6.151

Review 5.  Mutations in genes encoding regulators of mRNA decapping and translation initiation: links to intellectual disability.

Authors:  Dominique Weil; Amélie Piton; Davor Lessel; Nancy Standart
Journal:  Biochem Soc Trans       Date:  2020-06-30       Impact factor: 5.407

6.  DDX46 silencing inhibits cell proliferation by activating apoptosis and autophagy in cutaneous squamous cell carcinoma.

Authors:  Quan Lin; Hong-Juan Jin; Duo Zhang; Ling Gao
Journal:  Mol Med Rep       Date:  2020-09-14       Impact factor: 2.952
  6 in total

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