Literature DB >> 33857360

Transcription, translation, and DNA repair: new insights from emerging noncanonical substrates of RNA helicases.

Matthew P Russon1, Kirsten M Westerhouse1, Elizabeth J Tran1,2.   

Abstract

RNA helicases are enzymes that exist in all domains of life whose canonical functions include ATP-dependent remodeling of RNA structures and displacement of proteins from ribonucleoprotein complexes (RNPs). These enzymes play roles in virtually all processes of RNA metabolism, including pre-mRNA splicing, rRNA processing, nuclear mRNA export, translation and RNA decay. Here we review emerging noncanonical substrates of RNA helicases including RNA-DNA hybrids (R-loops) and RNA and DNA G-quadruplexes and discuss their biological significance.
© 2020 Walter de Gruyter GmbH, Berlin/Boston.

Entities:  

Keywords:  DEAD-box helicase; DEAH-box helicase; G-quadruplexes; R-loops; RNA helicase; RNA-DNA hybrid

Mesh：

Substances：

Year:  2020        PMID： 33857360      PMCID： PMC9157688          DOI： 10.1515/hsz-2020-0333

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   4.700


  60 in total

1.  An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism.

Authors:  Dana Hodroj; Bénédicte Recolin; Kamar Serhal; Susan Martinez; Nikolay Tsanov; Raghida Abou Merhi; Domenico Maiorano
Journal:  EMBO J       Date:  2017-03-17       Impact factor: 11.598

2.  RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria.

Authors:  Junjie U Guo; David P Bartel
Journal:  Science       Date:  2016-09-23       Impact factor: 47.728

3.  Biochemical Differences and Similarities between the DEAD-Box Helicase Orthologs DDX3X and Ded1p.

Authors:  Deepak Sharma; Andrea A Putnam; Eckhard Jankowsky
Journal:  J Mol Biol       Date:  2017-10-13       Impact factor: 5.469

4.  G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA.

Authors:  Banabihari Giri; Philip J Smaldino; Ryan G Thys; Steven D Creacy; Eric D Routh; Roy R Hantgan; Simon Lattmann; Yoshikuni Nagamine; Steven A Akman; James P Vaughn
Journal:  Nucleic Acids Res       Date:  2011-05-17       Impact factor: 16.971

5.  Characterization of the mammalian DEAD-box protein DDX5 reveals functional conservation with S. cerevisiae ortholog Dbp2 in transcriptional control and glucose metabolism.

Authors:  Zheng Xing; Siwen Wang; Elizabeth J Tran
Journal:  RNA       Date:  2017-04-14       Impact factor: 4.942

6.  SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.

Authors:  Chenlin Song; Agnes Hotz-Wagenblatt; Renate Voit; Ingrid Grummt
Journal:  Genes Dev       Date:  2017-08-08       Impact factor: 11.361

7.  RNA G-quadruplex is resolved by repetitive and ATP-dependent mechanism of DHX36.

Authors:  Ramreddy Tippana; Michael C Chen; Natalia A Demeshkina; Adrian R Ferré-D'Amaré; Sua Myong
Journal:  Nat Commun       Date:  2019-04-23       Impact factor: 14.919

8.  DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions.

Authors:  Markus Sauer; Stefan A Juranek; James Marks; Alessio De Magis; Hinke G Kazemier; Daniel Hilbig; Daniel Benhalevy; Xiantao Wang; Markus Hafner; Katrin Paeschke
Journal:  Nat Commun       Date:  2019-06-03       Impact factor: 14.919

9.  Enhancer-mediated enrichment of interacting JMJD3-DDX21 to ENPP2 locus prevents R-loop formation and promotes transcription.

Authors:  Deborah Argaud; Marie-Chloé Boulanger; Arnaud Chignon; Ghada Mkannez; Patrick Mathieu
Journal:  Nucleic Acids Res       Date:  2019-09-19       Impact factor: 16.971

Review 10.  Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation.

Authors:  Guillaume Giraud; Sophie Terrone; Cyril F Bourgeois
Journal:  BMB Rep       Date:  2018-12       Impact factor: 4.778
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  2 in total

1.  High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma.

Authors:  Xi Chen; Letao Lin; Guanyu Chen; Huzheng Yan; Zhenyu Li; Meigui Xiao; Xu He; Fujun Zhang; Yanling Zhang
Journal:  Front Oncol       Date:  2022-06-22       Impact factor: 5.738

2.  RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2.

Authors:  Farhad Vesuna; Ivan Akhrymuk; Amy Smith; Paul T Winnard; Shih-Chao Lin; Lauren Panny; Robert Scharpf; Kylene Kehn-Hall; Venu Raman
Journal:  Front Microbiol       Date:  2022-08-25       Impact factor: 6.064
  2 in total

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