| Literature DB >> 30835593 |
Kefeng Wang1, Joanna Lombard1,2, Tatjana Rundek1, Chuanhui Dong1, Carolina Marinovic Gutierrez1, Margaret M Byrne3, Matthew Toro4, Maria I Nardi5, Jack Kardys5, Li Yi2, José Szapocznik1,2, Scott C Brown1,2.
Abstract
Background Nature exposures may be associated with reduced risk of heart disease. The present study examines the relationship between objective measures of neighborhood greenness (vegetative presence) and 4 heart disease diagnoses (acute myocardial infarction, ischemic heart disease, heart failure, and atrial fibrillation) in a population-based sample of Medicare beneficiaries. Methods and Results The sample included 249 405 Medicare beneficiaries aged 65 years and older whose location ( ZIP +4) in Miami-Dade County, Florida, did not change from 2010 to 2011. Analyses examined relationships between greenness, measured by mean block-level normalized difference vegetation index from satellite imagery, and 4 heart disease diagnoses. Hierarchical regression analyses, in a multilevel framework, assessed the relationship of greenness to each heart disease diagnosis, adjusting successively for individual sociodemographics, neighborhood income, and biological risk factors (diabetes mellitus, hypertension, and hyperlipidemia). Higher greenness was associated with reduced heart disease risk, adjusting for individual sociodemographics and neighborhood income. Compared with the lowest tertile of greenness, the highest tertile of greenness was associated with reduced odds of acute myocardial infarction by 25% (odds ratio, 0.75; 95% CI , 0.63-0.90), ischemic heart disease by 20% (odds ratio, 0.80; 95% CI , 0.77-0.83), heart failure by 16% (odds ratio, 0.84; 95% CI , 0.80-0.88), and atrial fibrillation by 6% (odds ratio, 0.94; 95% CI , 0.87-1.00). Associations were attenuated after adjusting for biological risk factors, suggesting that cardiometabolic risk factors may partly mediate the greenness to heart disease relationships. Conclusions Neighborhood greenness may be associated with reduced heart disease risk. Strategies to increase area greenness may be a future means of reducing heart disease at the population level.Entities:
Keywords: Medicare beneficiaries; cardiovascular disease; greenness; heart disease; natural environment; neighborhood environment; population health
Mesh:
Year: 2019 PMID: 30835593 PMCID: PMC6475064 DOI: 10.1161/JAHA.118.010258
Source DB: PubMed Journal: J Am Heart Assoc ISSN: 2047-9980 Impact factor: 5.501
Figure 1Flow diagram for deriving final cohort of 249 405 Medicare beneficiaries aged 65 years and older with the same location in Miami‐Dade County, Florida, in 2010–2011. ESRD indicates end‐stage renal disease; MDC, Miami‐Dade County; NDVI, normalized difference vegetation index. Reproduced in part from Brown et al11 with permission. Copyright ©2016, Elsevier.
Descriptive Statistics for the Overall Sample and by Neighborhood Greenness Level (ie, Lowest, Middle, and Highest Tertiles on Block‐Level NDVI)
| Variable | Overall Sample (−0.40 to 0.429) (All NDVI) | Low NDVI (−0.40 to −0.06) (Lowest Tertile on NDVI) | Medium NDVI (−0.06 to 0.006) (Middle Tertile on NDVI) | High NDVI (0.006–0.429) (Highest Tertile on NDVI) | F (χ2) Test |
| ||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. (%) | Mean (SD) | No. (%) | Mean (SD) | No. (%) | Mean (SD) | No. (%) | Mean (SD) | |||
| No. (beneficiaries) | 249 405 (100.00) | ··· | 82 790 (33.20) | ··· | 83 314 (33.41) | ··· | 83 301 (33.40) | ··· | ··· | ··· |
| Main predictor: NDVI | ··· | −0.02 (0.09) | ··· | −0.11 (0.04) | ··· | −0.03 (0.02) | ··· | 0.07 (0.06) | 376 387 | <0.0001 |
| Neighborhood median household income | ··· | 51.4 (30.7) | ··· | 40.1 (21.9) | ··· | 48.4 (23.8) | ··· | 65.8 (37.9) | 17 167.3 | <0.0001 |
| Individual sociodemographics | ||||||||||
| Age | ··· | 76.33 (7.50) | ··· | 76.71 (7.55) | ··· | 76.30 (7.43) | ··· | 75.98 (7.51) | 196.40 | <0.0001 |
| Female sex | 58.33 | ··· | 58.79 | ··· | 58.66 | ··· | 57.53 | (32.9 | <0.0001 | |
| Race/ethnicity (RTI) | (21 963.2 | <0.0001 | ||||||||
| Hispanic, % | 65.56 | ··· | 80.29 | ··· | 68.77 | ··· | 47.71 | ··· | ||
| Non‐Hispanic white, % | 23.29 | ··· | 16.25 | ··· | 18.21 | ··· | 35.35 | ··· | ||
| Black, % | 11.15 | ··· | 3.45 | ··· | 13.02 | ··· | 16.94 | ··· | ||
| Biological risk factors | ||||||||||
| Diabetes mellitus diagnosis, % | 15.55 | ··· | 18.12 | ··· | 14.42 | ··· | 14.14 | ··· | (623.3 | <0.0001 |
| Hypertension diagnosis, % | 27.88 | ··· | 31.21 | ··· | 25.72 | ··· | 26.74 | ··· | (703.1 | <0.0001 |
| Hyperlipidemia diagnosis, % | 22.72 | ··· | 25.23 | ··· | 20.51 | ··· | 22.43 | ··· | (533.2 | <0.0001 |
| Outcome variables | ||||||||||
| AMI, % | 0.29 | 0.36 | 0.25 | 0.26 | (21.4 | <0.0001 | ||||
| IHD, % | 20.68 | 23.92 | 18.92 | 19.22 | (793.0 | <0.0001 | ||||
| HF, % | 7.56 | 9.06 | 7.05 | 6.58 | (412.4 | <0.0001 | ||||
| AF, % | 2.61 | 2.37 | 1.89 | 3.02 | (90.3 | <0.0001 | ||||
| Any heart disease, % | 22.41 | 25.58 | 20.55 | 21.12 | (721.6 | <0.0001 | ||||
RTI, Research Triangle Institute race code.
Mean normalized difference vegetation index (NDVI) was used to assess greenness/vegetative presence/absence at the Census block level (possible theoretical range of −1 to +1).
Neighborhood median household income is reported in thousands of dollars at the Census block‐group level using 2011 US Census data.
Race and ethnicity was assessed by US Centers for Medicare & Medicaid Services (CMS) for each beneficiary.
Biological risk factors and outcome variables were identified for each Medicare beneficiary, using CMS Beneficiary Summary File, Chronic Conditions segment.
Any heart disease refers to having any of the 4 forms of heart disease in the CMS Chronic Conditions Segment (acute myocardial infarction [AMI], ischemic heart disease [IHD], heart failure [HF], and atrial fibrillation [AF]).
NDVI Relationships to Health Outcomes in Unadjusted and Adjusted Models Adjusting for Individual Sociodemographics, Neighborhood Income, and/or Biological Risk Factors
| Health Outcome Variables (Models) | Model 1 (No Adjustment) | Model 2 (Individual Sociodemographic Covariates) | Model 3 (Individual Sociodemographic Covariates, Plus Neighborhood‐Level Income) | Model 4 (Individual Sociodemographic Covariates, Neighborhood‐Level Income, Plus Biological Risk Factors) | ||||
|---|---|---|---|---|---|---|---|---|
| OR and (95% CI) |
| OR and (95% CI) |
| OR and (95% CI) |
| OR and (95% CI) |
| |
| AMI | ||||||||
| Low NDVI | 1 | 1 | 1 | 1 | ||||
| Medium NDVI | 0.97 (0.80–1.17) | 0.7459 | 0.97 (0.80–1.17) | 0.7163 | 0.94 (0.77–1.14) | 0.5231 | 0.96 (0.79–1.17) | 0.7086 |
| High NDVI | 0.70 (0.58–0.83) | <0.0001 | 0.74 (0.62–0.88) | 0.0008 | 0.75 (0.63–0.90) | 0.0018 | 0.87 (0.73–1.04) | 0.1357 |
|
| 0.0003 | 0.0035 | 0.0231 | 0.2909 | ||||
| IHD | ||||||||
| Low NDVI | 1 | 1 | 1 | 1 | ||||
| Medium NDVI | 0.94 (0.91–0.97) | 0.0003 | 0.92 (0.89–0.96) | <0.0001 | 0.97 (0.94–1.01) | 0.0961 | 1.03 (0.99–1.07) | 0.1809 |
| High NDVI | 0.75 (0.72–0.78) | <0.0001 | 0.81 (0.79–0.84) | <0.0001 | 0.80 (0.77–0.83) | <0.0001 | 0.86 (0.83–0.90) | <0.0001 |
|
| <0.0001 | <0.0001 | <0.0001 | <0.0001 | ||||
| HF | ||||||||
| Low NDVI | 1 | 1 | 1 | 1 | ||||
| Medium NDVI | 1.09 (1.04–1.14) | 0.0003 | 1.03 (0.99–1.08) | 0.1559 | 1.02 (0.97–1.07) | 0.4930 | 1.03 (0.98–1.08) | 0.2277 |
| High NDVI | 0.77 (0.74–0.81) | <0.0001 | 0.83 (0.79–0.87) | <0.0001 | 0.84 (0.80–0.88) | <0.0001 | 0.95 (0.91–1.00) | 0.0318 |
|
| <0.0001 | <0.0001 | <0.0001 | 0.0015 | ||||
| AF | ||||||||
| Low NDVI | 1 | 1 | 1 | 1 | ||||
| Medium NDVI | 0.73 (0.68–0.78) | <0.0001 | 0.82 (0.77–0.88) | <0.0001 | 0.91 (0.84–0.97) | 0.0062 | 0.92 (0.86–0.98) | 0.0133 |
| High NDVI | 0.93 (0.86–1.00) | 0.0603 | 0.98 (0.91–1.05) | 0.5053 | 0.94 (0.87–1.00) | 0.0674 | 1.07 (1.00–1.14) | 0.0634 |
|
| <0.0001 | <0.0001 | 0.3435 | <0.0001 | ||||
| Any heart disease | ||||||||
| Low NDVI | 1 | 1 | 1 | 1 | ||||
| Medium NDVI | 0.93 (0.90–0.96) | <0.0001 | 0.92 (0.89–0.95) | <0.0001 | 0.97 (0.94–1.01) | 0.1177 | 1.03 (0.99–1.07) | 0.1676 |
| High NDVI | 0.76 (0.74–0.79) | <0.0001 | 0.83 (0.80–0.86) | <0.0001 | 0.81 (0.78–0.84) | <0.0001 | 0.88 (0.84–0.91) | <0.0001 |
|
| <0.0001 | <0.0001 | <0.0001 | <0.0001 | ||||
Tertiles for mean greenness: low (reference level), medium, and high normalized difference vegetation index (NDVI; see Table 1). AF indicates atrial fibrillation; AMI, acute myocardial infarction; HF, heart failure; IHD, ischemic heart disease; OR, odds ratio.
Individual sociodemographics: age, sex, and race/ethnicity.
Neighborhood‐level income: neighborhood median household income.
Biological risk factors: diabetes mellitus, hypertension, and hyperlipidemia.
Statistically significant results (P<0.05).
P value for linear trends reported across the 3 tertiles of greenness.