Literature DB >> 21079589

Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.

Sivaraman Dandapani1, Lisa A Marcaurelle.   

Abstract

The synthesis and biological annotation of small molecules from underexplored chemical space will play a central role in the development of drugs for challenging targets currently being identified in frontier areas of biological research such as human genetics.

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Year:  2010        PMID： 21079589     DOI： 10.1038/nchembio.479

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  13 in total

Review 1.  Integrating cheminformatic analysis in combinatorial chemistry.

Authors:  James F Blake
Journal:  Curr Opin Chem Biol       Date:  2004-08       Impact factor: 8.822

Review 2.  Enhancements of screening collections to address areas of unmet medical need: an industry perspective.

Authors:  David H Drewry; Ricardo Macarron
Journal:  Curr Opin Chem Biol       Date:  2010-04-21       Impact factor: 8.822

Review 3.  Current strategies for diversity-oriented synthesis.

Authors:  Sivaraman Dandapani; Lisa A Marcaurelle
Journal:  Curr Opin Chem Biol       Date:  2010-04-19       Impact factor: 8.822

Review 4.  On the potential of natural products in the discovery of pharma leads: a case for reassessment.

Authors:  Samuel Danishefsky
Journal:  Nat Prod Rep       Date:  2010-04-09       Impact factor: 13.423

Review 5.  Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors:  David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

Review 6.  Diversity-oriented synthesis: exploring the intersections between chemistry and biology.

Authors:  Derek S Tan
Journal:  Nat Chem Biol       Date:  2005-07       Impact factor: 15.040

7.  Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.

Authors:  Lisa A Marcaurelle; Charles Johannes; Daniel Yohannes; Bonnie P Tillotson; David Mann
Journal:  Bioorg Med Chem Lett       Date:  2009-03-17       Impact factor: 2.823

8.  Spiroindolones, a potent compound class for the treatment of malaria.

Authors:  Matthias Rottmann; Case McNamara; Bryan K S Yeung; Marcus C S Lee; Bin Zou; Bruce Russell; Patrick Seitz; David M Plouffe; Neekesh V Dharia; Jocelyn Tan; Steven B Cohen; Kathryn R Spencer; Gonzalo E González-Páez; Suresh B Lakshminarayana; Anne Goh; Rossarin Suwanarusk; Timothy Jegla; Esther K Schmitt; Hans-Peter Beck; Reto Brun; Francois Nosten; Laurent Renia; Veronique Dartois; Thomas H Keller; David A Fidock; Elizabeth A Winzeler; Thierry T Diagana
Journal:  Science       Date:  2010-09-03       Impact factor: 47.728

9.  Escape from flatland: increasing saturation as an approach to improving clinical success.

Authors:  Frank Lovering; Jack Bikker; Christine Humblet
Journal:  J Med Chem       Date:  2009-11-12       Impact factor: 7.446

10.  A small molecule that binds Hedgehog and blocks its signaling in human cells.

Authors:  Benjamin Z Stanton; Lee F Peng; Nicole Maloof; Kazuo Nakai; Xiang Wang; Jay L Duffner; Kennedy M Taveras; Joel M Hyman; Sam W Lee; Angela N Koehler; James K Chen; Julia L Fox; Anna Mandinova; Stuart L Schreiber
Journal:  Nat Chem Biol       Date:  2009-01-18       Impact factor: 15.040
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  59 in total

1.  Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases.

Authors:  Ziyou Cui; Shannamar Dewey; Aldrin V Gomes
Journal:  Am J Cardiovasc Dis       Date:  2011-09-10

Review 2.  Fine-tuning multiprotein complexes using small molecules.

Authors:  Andrea D Thompson; Amanda Dugan; Jason E Gestwicki; Anna K Mapp
Journal:  ACS Chem Biol       Date:  2012-07-23       Impact factor: 5.100

3.  A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.

Authors:  Henning S G Beckmann; Feilin Nie; Caroline E Hagerman; Henrik Johansson; Yaw Sing Tan; David Wilcke; David R Spring
Journal:  Nat Chem       Date:  2013-08-25       Impact factor: 24.427

Review 4.  Chemical probes and drug leads from advances in synthetic planning and methodology.

Authors:  Christopher J Gerry; Stuart L Schreiber
Journal:  Nat Rev Drug Discov       Date:  2018-04-13       Impact factor: 84.694

5.  Discovery of new antimalarial chemotypes through chemical methodology and library development.

Authors:  Lauren E Brown; Ken Chih-Chien Cheng; Wan-Guo Wei; Pingwei Yuan; Peng Dai; Richard Trilles; Feng Ni; Jing Yuan; Ryan MacArthur; Rajarshi Guha; Ronald L Johnson; Xin-zhuan Su; Melissa M Dominguez; John K Snyder; Aaron B Beeler; Scott E Schaus; James Inglese; John A Porco
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-15       Impact factor: 11.205

6.  Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.

Authors:  Paul A Clemons; J Anthony Wilson; Vlado Dančík; Sandrine Muller; Hyman A Carrinski; Bridget K Wagner; Angela N Koehler; Stuart L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-11       Impact factor: 11.205

7.  Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity.

Authors:  Amos B Smith; Won-Suk Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-18       Impact factor: 11.205

8.  A convergent, modular approach to functionalized 2,1-borazaronaphthalenes from 2-aminostyrenes and potassium organotrifluoroborates.

Authors:  Steven R Wisniewski; Courtney L Guenther; O Andreea Argintaru; Gary A Molander
Journal:  J Org Chem       Date:  2013-12-11       Impact factor: 4.354

Review 9.  Expanding the number of 'druggable' targets: non-enzymes and protein-protein interactions.

Authors:  Leah N Makley; Jason E Gestwicki
Journal:  Chem Biol Drug Des       Date:  2013-01       Impact factor: 2.817

Review 10.  Advances in discovering small molecules to probe protein function in a systems context.

Authors:  Shelby K Doyle; Marius S Pop; Helen L Evans; Angela N Koehler
Journal:  Curr Opin Chem Biol       Date:  2015-11-23       Impact factor: 8.822
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