Yi Zhang1, Wenyi Mi2, Yongming Xue3, Xiaobing Shi2, Tatiana G Kutateladze1. 1. a Department of Pharmacology , University of Colorado School of Medicine , Aurora , CO , USA. 2. b Center for Epigenetics Van Andel Research Institute , Grand Rapids , MI , USA. 3. c Genetics and Epigenetics Graduate Program , The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences , Houston , TX , USA.
Abstract
Although relatively small in size, the ZZ-type zinc finger (ZZ) domain is a versatile signaling module that is implicated in a diverse set of cell signaling events. Here, we highlight the most recent studies focused on the ZZ domain function as a histone reader and a sensor of protein degradation signals. We review and compare the molecular and structural mechanisms underlying targeting the amino-terminal sequences of histone H3 and arginylated substrates by the ZZ domain. We also discuss the ZZ domain sensitivity to histone PTMs and summarize biological outcomes associated with the recognition of histone and non-histone ligands by the ZZ domain-containing proteins and complexes.
Although relatively small in size, the n class="Chemical">ZZ-type zinpan>c finpan>ger (pan> class="Chemical">ZZ) domain is a versatile signaling module that is implicated in a diverse set of cell signaling events. Here, we highlight the most recent studies focused on the ZZ domain function as a histone reader and a sensor of protein degradation signals. We review and compare the molecular and structural mechanisms underlying targeting the amino-terminal sequences of histone H3 and arginylated substrates by the ZZ domain. We also discuss the ZZ domain sensitivity to histone PTMs and summarize biological outcomes associated with the recognition of histone and non-histone ligands by the ZZ domain-containing proteins and complexes.
Authors: S A Gayther; S J Batley; L Linger; A Bannister; K Thorpe; S F Chin; Y Daigo; P Russell; A Wilson; H M Sowter; J D Delhanty; B A Ponder; T Kouzarides; C Caldas Journal: Nat Genet Date: 2000-03 Impact factor: 38.330
Authors: Vladimir Kirkin; Trond Lamark; Yu-Shin Sou; Geir Bjørkøy; Jennifer L Nunn; Jack-Ansgar Bruun; Elena Shvets; David G McEwan; Terje H Clausen; Philipp Wild; Ivana Bilusic; Jean-Philippe Theurillat; Aud Øvervatn; Tetsuro Ishii; Zvulun Elazar; Masaaki Komatsu; Ivan Dikic; Terje Johansen Journal: Mol Cell Date: 2009-02-27 Impact factor: 17.970
Authors: Zhanyun Tang; Wei-Yi Chen; Miho Shimada; Uyen T T Nguyen; Jaehoon Kim; Xiao-Jian Sun; Toru Sengoku; Robert K McGinty; Joseph P Fernandez; Tom W Muir; Robert G Roeder Journal: Cell Date: 2013-07-18 Impact factor: 41.582
Authors: Adam H Tencer; Jiuyang Liu; Jing Zhu; Nathaniel T Burkholder; Yi Zhang; Wenwen Wu; Brian D Strahl; Tomohiko Ohta; Tatiana G Kutateladze Journal: Sci Rep Date: 2022-04-11 Impact factor: 4.379
Authors: Abderrahman Chargui; Amine Belaid; Papa Diogop Ndiaye; Véronique Imbert; Michel Samson; Jean-Marie Guigonis; Michel Tauc; Jean-François Peyron; Philippe Poujeol; Patrick Brest; Paul Hofman; Baharia Mograbi Journal: Cancers (Basel) Date: 2021-05-20 Impact factor: 6.639
Authors: Kathryn S Evans; Stefan Zdraljevic; Lewis Stevens; Kimberly Collins; Robyn E Tanny; Erik C Andersen Journal: PLoS Genet Date: 2020-11-11 Impact factor: 5.917