| Literature DB >> 35427480 |
Kierra A Franklin1, Cara E Shields1, Karmella A Haynes2.
Abstract
Chromatin is a system of proteins and DNA that regulates chromosome organization and gene expression in eukaryotes. Essential features that support these processes include biochemical marks on histones and DNA, 'writer' enzymes that generate or remove these marks and proteins that translate the marks into transcriptional regulation: reader-effectors. Here, we review recent studies that reveal how reader-effectors drive chromatin-mediated processes. Advances in proteomics and epigenomics have accelerated the discovery of chromatin marks and their correlation with gene states, outpacing our understanding of the corresponding reader-effectors. Therefore, we summarize the current state of knowledge and open questions about how reader-effectors impact cellular function and human disease and discuss how synthetic biology can deepen our knowledge of reader-effector activity.Entities:
Keywords: cell developmental disease; chromatin modifications; epigenome; protein engineering; signal integration; transcriptional regulation
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Year: 2022 PMID： 35427480 PMCID： PMC9074927 DOI： 10.1016/j.tibs.2022.03.002
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 14.264