| Literature DB >> 34169552 |
Yutaro Hama1, Sidi Zhang1, Noboru Mizushima1.
Abstract
Selective autophagy relies on adaptor proteins to bind and transport cargos (or substrates) to the lysosome or vacuole, yet the mechanisms for cargo recognition are not well understood. In this issue, Wang et al (2021) showed that in the fission yeast, Nbr1, a homolog of a mammalian selective autophagy adaptor, recognizes vacuolar hydrolases Ams1 and Ape4 through both versatile and cargo-specific interactions with the Nbr1 ZZ1 domain.Entities:
Mesh:
Substances:
Year: 2021 PMID: 34169552 PMCID: PMC8327937 DOI: 10.15252/embj.2021108777
Source DB: PubMed Journal: EMBO J ISSN: 0261-4189 Impact factor: 14.012