| Literature DB >> 30648479 |
Shannon E Anderson1,2, Woojin M Han2,3, Vunya Srinivasa2,4, Mahir Mohiuddin1,2, Marissa A Ruehle1,2, June Young Moon2,4, Eunjung Shin2,4, Cheryl L San Emeterio1,2, Molly E Ogle1,2, Edward A Botchwey1,2, Nick J Willett1,2,5,6, Young C Jang1,2,4.
Abstract
IMPACT STATEMENT: The goal of this study was to determine the threshold for a critically sized, nonhealing muscle defect by characterizing key components in the balance between fibrosis and regeneration as a function of injury size in the mouse quadriceps. There is currently limited understanding of what leads to a critically sized muscle defect and which muscle regenerative components are functionally impaired. With the substantial increase in preclinical VML models as testbeds for tissue engineering therapeutics, defining the critical threshold for VML injuries will be instrumental in characterizing therapeutic efficacy and potential for subsequent translation.Entities:
Keywords: neuromuscular junction; satellite cells; skeletal muscle; volumetric muscle loss
Mesh：
Year: 2019 PMID： 30648479 PMCID： PMC6389771 DOI： 10.1089/ten.TEC.2018.0324
Source DB: PubMed Journal: Tissue Eng Part C Methods ISSN： 1937-3384 Impact factor: 3.056