| Literature DB >> 30646265 |
Sharon Leitch1, Paul Glue2, Andrew R Gray3, Philippa Greco4, Yoram Barak2.
Abstract
Importance: Loneliness is associated with reduced health-related quality of life and increased morbidity and mortality and typically worsens with aging.Entities:
Mesh:
Year: 2018 PMID: 30646265 PMCID: PMC6324443 DOI: 10.1001/jamanetworkopen.2018.3880
Source DB: PubMed Journal: JAMA Netw Open ISSN: 2574-3805
Characteristics of the Study Participants
| Characteristic | Total | Participants With Loneliness Data | Noncentenarians | Centenarians | Lonely |
|---|---|---|---|---|---|
| Age, y | |||||
| 65-69 | 5952 (8.1) | 5948 | NA | NA | 1354 (22.8) |
| 70-74 | 8898 (12.1) | 8895 | NA | NA | 1789 (20.1) |
| 75-79 | 13 360 (18.2) | 13 355 | NA | NA | 2539 (19.0) |
| 80-84 | 17 298 (23.6) | 17 284 | NA | NA | 3359 (19.4) |
| 85-89 | 16 856 (23.0) | 16 850 | NA | NA | 3353 (19.9) |
| 90-94 | 8807 (23.0) | 8804 | NA | NA | 1806 (20.5) |
| 95-99 | 1924 (2.6) | 1923 | NA | NA | 335 (17.4) |
| 100-109 | 191 (0.3) | 191 | NA | NA | 28 (14.7) |
| Mean (range) | 81.4 (65-109) | 81.4 (65-109) | 81.4 (65-99) | 100.9 (100-109) | NA |
| Sex | |||||
| Male | 31 576 (43.1) | 31 557 | 31 502 (43.2) | 55 (28.8) | 5435(17.2) |
| Female | 41 641 (56.9) | 41 624 | 41 488 (56.8) | 136 (71.2) | 9112 (21.9) |
| Missing | 69 | 69 | NA | NA | NA |
| Race/ethnicity | |||||
| European | 63 203 (86.3) | 63 178 | 63 001 (86.3) | 177 (92.7) | 12 481 (19.8) |
| Māori | 4454 (6.1) | 4453 | 4448 (6.1) | 5 (2.6) | 914 (20.5) |
| Pacific | 2607 (3.6) | 2604 | 2602 (3.6) | 2 (1.0) | 472 (18.1) |
| Asian | 2228 (3.0) | 2221 | 2216 (3.0) | 5 (2.6) | 496 (22.3) |
| Other (including MELAA) | 741 (1.0) | 741 | 739 (1.0) | 2 (1.0) | 190 (25.6) |
| Missing | 53 | 53 | NA | NA | NA |
| Season | |||||
| Summer | 15 440 (21.0) | 15 432 | 15 385 (21.1) | 47 (24.6) | 3004 (19.5) |
| Autumn | 18 639 (25.4) | 18 629 | 18 587 (25.4) | 42 (22.0) | 3821 (20.5) |
| Winter | 19 951 (27.2) | 19 939 | 19 886 (27.2) | 53 (27.7) | 3904 (19.6) |
| Spring | 19 256 (26.3) | 19 250 | 19 201 (26.3) | 49 (25.7) | 3834 (19.9) |
| Missing | 0 | 0 | NA | NA | NA |
| Marital status | |||||
| Married, civil union, or de facto committed relationship | 31 092 (42.5) | 31 073 | 31 060 (42.6) | 13 (6.8) | 3933 (12.7) |
| Never married | 3754 (5.1) | 3751 | 3745 (5.1) | 6 (3.1) | 663 (17.7) |
| Widowed | 31 737 (43.4) | 31 724 | 31 554 (43.2) | 170 (89.0) | 8293 (26.1) |
| Separated/divorced | 5760 (7.9) | 5759 | 5758 (7.9) | 1 (0.5) | 1515 (26.3) |
| Other | 843 (1.2) | 843 | 842 (1.2) | 1 (0.5) | 140 (16.6) |
| Missing | 100 | 100 | NA | NA | NA |
| Family support | |||||
| No | 7867 (10.7) | 7866 | 7854 (10.8) | 12 (6.3) | 2061 (26.2) |
| Yes | 65 409 (89.3) | 65 375 | 65 196 (89.2) | 179 (93.7) | 12 501 (19.1) |
| Missing | 10 | 9 | NA | NA | NA |
| Living arrangements | |||||
| Alone | 32 061 (43.7) | 32 052 | 31 943 (43.7) | 109 (57.1) | 8926 (27.8) |
| With partner | 28 357 (38.7) | 28 342 | 28 333 (38.8) | 9 (4.7) | 3138 (11.1) |
| With family | 10 047 (13.7) | 10 039 | 9976 (13.7) | 63 (33.0) | 2092 (20.8) |
| With others | 2821 (3.8) | 2817 | 2807 (3.8) | 10 (5.2) | 407 (14.4) |
| Missing | 0 | 0 | NA | NA | NA |
| Depression | |||||
| None, DRS score of 0 | 43 624 (59.5) | 43 589 | 43 455 (59.5) | 134 (70.2) | 5902 (13.5) |
| Mild-moderate, DRS scores of 1-7 | 28 687 (39.1) | 28 687 | 28 633 (39.2) | 54 (28.3) | 8218 (28.6) |
| Moderate-severe, DRS scores of 8-14 | 972 (1.3) | 971 | 968 (1.3) | 3 (1.6) | 442 (45.5) |
| Missing | 3 | 3 | NA | NA | NA |
Abbreviations: DRS, Depression Rating Scale; MELAA, Middle Eastern, Latin American, African; NA, not applicable.
Data are presented as number (percentage) of participants unless otherwise indicated. All percentages are column percentages except for percentages for lonely, which indicates the percentage of respondents in that group who were lonely.
Regression Models
| Variable | Unadjusted (n ≤73 250) | Partially Adjusted (n = 73 128) | Fully Adjusted (n = 73 079) | |||
|---|---|---|---|---|---|---|
| RR (95% CI) | RR (95% CI) | RR (95% CI) | ||||
| Differences in risk between those aged 100.9 y and 81.4 y | 0.78 (0.67-0.92) | .002 | 0.75 (0.64-0.88) | <.001 | 0.68 (0.58-0.79) | <.001 |
| Sex | ||||||
| Male | 0.79 (0.76-0.81) | <.001 | 0.78 (0.76-0.81) | <.001 | 1.00 (0.97-1.03) | .84 |
| Female | 1 [Reference] | 1 [Reference] | 1 [Reference] | |||
| Ethnicity | ||||||
| European | 1 [Reference] | <.001 | 1 [Reference] | <.001 | 1 [Reference] | <.001 |
| Māori | 1.04 (0.98-1.10) | 1.00 (0.95-1.07) | 1.02 (0.96-1.08) | |||
| Pacific | 0.92 (0.84-1.00) | 0.90 (0.83-0.98) | 1.06 (0.97-1.15) | |||
| Asian | 1.13 (1.04-1.22) | 1.12 (1.04-1.21) | 1.29 (1.20-1.40) | |||
| Other (including MELAA) | 1.30 (1.15-1.47) | 1.28 (1.13-1.45) | 1.31 (1.16-1.47) | |||
| Season | ||||||
| Summer | 1 [Reference] | .06 | 1 [Reference] | .06 | 1 [Reference] | .06 |
| Autumn | 1.05 (1.01-1.10) | 1.05 (1.01-1.10) | 1.05 (1.01-1.10) | |||
| Winter | 1.01 (0.96-1.05) | 1.01 (0.96-1.05) | 1.01 (0.97-1.05) | |||
| Spring | 1.02 (0.98-1.07) | 1.03 (0.98-1.07) | 1.03 (0.98-1.15) | |||
| Marital status | ||||||
| Married, civil union, or de facto committed relationship | 1 [Reference] | <.001 | NA | NA | 1 [Reference] | <.001 |
| Never married | 1.40 (1.30-1.51) | NA | 0.67 (0.62-0.74) | |||
| Widowed | 2.07 (2.00-2.14) | NA | 1.06 (1.00-1.12) | |||
| Separated/divorced | 2.08 (1.97-2.19) | NA | 0.92 (0.86-0.99) | |||
| Other | 1.31 (1.12-1.53) | NA | 0.63 (0.54-0.74) | |||
| Family support | ||||||
| No | 1 [Reference] | <.001 | NA | NA | 1 [Reference] | <.001 |
| Yes | 0.73 (0.70-0.76) | NA | 0.83 (0.79-0.86) | |||
| Living arrangements | ||||||
| Alone | 1 [Reference] | <.001 | NA | NA | 1 [Reference] | <.001 |
| With partner | 0.40 (0.38-0.41) | NA | 0.37 (0.35-0.40) | |||
| With family | 0.75 (0.72-0.78) | NA | 0.71 (0.68-0.74) | |||
| With others | 0.52 (0.47-0.57) | NA | 0.49 (0.45-0.54) | |||
| Depression | ||||||
| None, DRS score of 0 | 1 [Reference] | <.001 | NA | NA | 1 [Reference] | <.001 |
| Mild-moderate, DRS scores of 1-7 | 2.12 (2.05-2.18) | NA | 2.17 (2.11-2.24) | |||
| Moderate-severe, DRS scores of 8-14 | 3.36 (3.13-3.62) | NA | 3.45 (3.22-3.70) | |||
Abbreviations: DRS, Depression Rating Scale; MELAA, Middle Eastern, Latin American, African; NA, not applicable; RR, risk ratio.
Figure 1. Association Between Loneliness and Age
A, Five-year age bands (unadjusted). B, Unadjusted cubic age. C, Cubic age adjusted for potentially modifiable variables. D, Cubic age adjusted for all variables. Error bars indicate 95% CIs.
Figure 2. Modification of the Association Between Loneliness and Age
Error bars indicate 95% CIs.