Oscar Ribeiro1, Natália Duarte2, Laetitia Teixeira3, Constança Paúl4. 1. UnIFai and CINTESIS.ICBAS,University of Porto,Porto;ISSSP,Porto;University of Aveiro,Aveiro,Portugal. 2. UnIFai.ICBAS,University of Porto,Porto,Portugal. 3. UnIFai and CINTESIS.ICBAS and ISPUP-EPIUnit,University of Porto,Porto,Portugal. 4. UnIFai and CINTESIS.ICBAS,University of Porto,Porto,Portugal.
Abstract
BACKGROUND: Physical frailty and depression are common comorbid conditions that have important impact on older adults. Few studies however have examined their co-occurrence in centenarians. This paper explores the relationship between the two conditions and the most characteristic depressive symptoms associated with the frailty syndrome. METHODS: Data come from two Portuguese Centenarian Studies. Frailty was measured using Fried's phenotype, which includes at least three clinical signs: exhaustion, weight loss, weakness, slowness, and low physical activity level; the Geriatric Depression Scale was used to assess depression. Descriptive comparison and binary logistic regression models were used for data analysis. RESULTS: The final sample comprised 91 centenarians (mean age = 101.0, SD = 1.3; 85.7% female). From these, 5.5% were classified as robust, 42.9% as pre-frail, and 51.6% as frail. The prevalence of depression in the whole sample was 35.2% (51.1% in frail centenarians; 21.1% in pre-frail centenarians; 0% in robust centenarians). Frail centenarians presented higher risk of depression (OR = 3.92; 95% CI 1.48-10.4) when compared to pre-frail centenarians. Findings from the multivariable model (gender, living arrangements, education, cognition, subjective health, current illness, and functionality) revealed that only subjective health remained significant. CONCLUSION: It seems that depression is a comorbid clinical independent condition that is frequent in frail and pre-frail centenarians.
BACKGROUND: Physical frailty and depression are common comorbid conditions that have important impact on older adults. Few studies however have examined their co-occurrence in centenarians. This paper explores the relationship between the two conditions and the most characteristic depressive symptoms associated with the frailty syndrome. METHODS: Data come from two Portuguese Centenarian Studies. Frailty was measured using Fried's phenotype, which includes at least three clinical signs: exhaustion, weight loss, weakness, slowness, and low physical activity level; the Geriatric Depression Scale was used to assess depression. Descriptive comparison and binary logistic regression models were used for data analysis. RESULTS: The final sample comprised 91 centenarians (mean age = 101.0, SD = 1.3; 85.7% female). From these, 5.5% were classified as robust, 42.9% as pre-frail, and 51.6% as frail. The prevalence of depression in the whole sample was 35.2% (51.1% in frail centenarians; 21.1% in pre-frail centenarians; 0% in robust centenarians). Frail centenarians presented higher risk of depression (OR = 3.92; 95% CI 1.48-10.4) when compared to pre-frail centenarians. Findings from the multivariable model (gender, living arrangements, education, cognition, subjective health, current illness, and functionality) revealed that only subjective health remained significant. CONCLUSION: It seems that depression is a comorbid clinical independent condition that is frequent in frail and pre-frail centenarians.
Authors: Armanda Teixeira-Gomes; Blanca Laffon; Vanessa Valdiglesias; Johanna M Gostner; Thomas Felder; Carla Costa; Joana Madureira; Dietmar Fuchs; João Paulo Teixeira; Solange Costa Journal: Antioxidants (Basel) Date: 2021-12-10