Literature DB >> 3054878

Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2.

L Chen1, Y Mory, A Zilberstein, M Revel.   

Abstract

Recombinant human interferon-beta 2 was produced in Escherichia coli by direct expression of cDNA encoding the mature protein sequence. At concentrations that stimulate DNA synthesis and growth in B-cell hybridomas and plasmacytomas, the cytokine was found to exert a strong inhibition on the growth of a number of carcinoma and leukemia/lymphoma cell lines. This antigrowth effect was observed in clonogenic assays and by measurements of cell number and thymidine incorporation in growing cultures. The effect was blocked by antibodies to a synthetic peptide from the N terminus of the molecule. Normal diploid fibroblasts were inhibited at concentrations higher than those needed for breast carcinoma cells.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3054878      PMCID： PMC282349          DOI： 10.1073/pnas.85.21.8037

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  Polymyxin B use does not ensure endotoxin-free solution.

Authors:  M J Kluger; R Singer; S M Eiger
Journal:  J Immunol Methods       Date:  1985-10-24       Impact factor: 2.303

Review 2.  Growth factors and cancer.

Authors:  A S Goustin; E B Leof; G D Shipley; H L Moses
Journal:  Cancer Res       Date:  1986-03       Impact factor: 12.701

3.  Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.

Authors:  J Weissenbach; Y Chernajovsky; M Zeevi; L Shulman; H Soreq; U Nir; D Wallach; M Perricaudet; P Tiollais; M Revel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

Review 4.  Redefining interferon: the interferon-like antiviral effects of certain cytokines (interleukin-1, interferon-beta 2, interferon-gamma) may be indirect or side effects.

Authors:  A Billiau
Journal:  Antiviral Res       Date:  1987-09       Impact factor: 5.970

Review 5.  Autocrine growth factors and cancer.

Authors:  M B Sporn; A B Roberts
Journal:  Nature       Date:  1985 Feb 28-Mar 6       Impact factor: 49.962

6.  gamma-Interferon increases expression of class III complement genes C2 and factor B in human monocytes and in murine fibroblasts transfected with human C2 and factor B genes.

Authors:  R C Strunk; F S Cole; D H Perlmutter; H R Colten
Journal:  J Biol Chem       Date:  1985-12-05       Impact factor: 5.157

7.  Chronic B-lymphocytic leukemia cells proliferate and differentiate following exposure to interferon in vitro.

Authors:  L Ostlund; S Einhorn; K H Robèrt; G Juliusson; P Biberfeld
Journal:  Blood       Date:  1986-01       Impact factor: 22.113

8.  Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation.

Authors:  M Kohase; D Henriksen-DeStefano; L T May; J Vilcek; P B Sehgal
Journal:  Cell       Date:  1986-06-06       Impact factor: 41.582

9.  Differential regulation of HLA-DR mRNAs and cell surface antigens by interferon.

Authors:  F Rosa; D Hatat; A Abadie; D Wallach; M Revel; M Fellous
Journal:  EMBO J       Date:  1983       Impact factor: 11.598

10.  Autogenous production of interferon-beta switches on HLA genes during differentiation of histiocytic lymphoma U937 cells.

Authors:  A Yarden; H Shure-Gottlieb; J Chebath; M Revel; A Kimchi
Journal:  EMBO J       Date:  1984-05       Impact factor: 11.598
View more
  44 in total

1.  IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells.

Authors:  Chih-Hsin Tang; Cheng-Fong Chen; Wei-Ming Chen; Yi-Chin Fong
Journal:  J Biol Chem       Date:  2011-01-28       Impact factor: 5.157

Review 2.  Growth inhibitors: molecular diversity and roles in cell proliferation.

Authors:  K Miyazaki; T Horio
Journal:  In Vitro Cell Dev Biol       Date:  1989-10

Review 3.  Interleukin-6 and the acute phase response.

Authors:  P C Heinrich; J V Castell; T Andus
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

4.  Interleukin-6 and renal cell cancer: production, regulation, and growth effects.

Authors:  A S Koo; C Armstrong; B Bochner; T Shimabukuro; C L Tso; J B deKernion; A Belldegrum
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

5.  Interleukin-6 stimulates cell proliferation of rat pituitary clonal cell lines in vitro.

Authors:  T Sawada; K Koike; Y Kanda; H Ikegami; H Jikihara; T Maeda; Y Osako; K Hirota; A Miyake
Journal:  J Endocrinol Invest       Date:  1995-02       Impact factor: 4.256

6.  Preliminary study on the cooperation of IL-6 and mB7-1 in the induction of effective antitumor immunity in vitro.

Authors:  S Qu; R Liu; Y Wang; J Wang
Journal:  J Tongji Med Univ       Date:  1999

7.  Induction of urinary interleukin-1 (IL-1), IL-2, IL-6, and tumour necrosis factor during intravesical immunotherapy with bacillus Calmette-Guérin in superficial bladder cancer.

Authors:  E C De Boer; W H De Jong; P A Steerenberg; L A Aarden; E Tetteroo; E R De Groot; A P Van der Meijden; P D Vegt; F M Debruyne; E J Ruitenberg
Journal:  Cancer Immunol Immunother       Date:  1992       Impact factor: 6.968

Review 8.  Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokine.

Authors:  M Revel
Journal:  Experientia       Date:  1989-06-15

9.  Parvoviruses are inefficient in inducing interferon-beta, tumor necrosis factor-alpha, or interleukin-6 in mammalian cells.

Authors:  J R Schlehofer; M Rentrop; D N Männel
Journal:  Med Microbiol Immunol       Date:  1992       Impact factor: 3.402

10.  Interleukin-6 induces increased motility, cell-cell and cell-substrate dyshesion and epithelial-to-mesenchymal transformation in breast cancer cells.

Authors:  P B Sehgal
Journal:  Oncogene       Date:  2010-02-08       Impact factor: 9.867
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.