Literature DB >> 2871942

Induction of beta 2-interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation.

M Kohase, D Henriksen-DeStefano, L T May, J Vilcek, P B Sehgal.   

Abstract

Earlier studies showed that tumor necrosis factor (TNF) exerts a mitogenic effect in human diploid fibroblasts. Here we demonstrate that purified E. coli-derived recombinant human TNF inhibits encephalomyocarditis virus replication in "aged" human fibroblasts. Addition of neutralizing antibodies to human beta interferon (IFN-beta) blocked the antiviral action of TNF, indicating that this action is mediated by the generation of IFN-beta. We also show that antiserum to IFN-beta enhanced the mitogenic effect of TNF in confluent, serum-starved human fibroblasts, suggesting that induction of IFN-beta by TNF represents a physiological negative feedback mechanism regulating cell proliferation. Blot hybridization analysis of cytoplasmic polyadenylated RNA showed that TNF induced IFN-beta 2 mRNA, whereas no induction of IFN-beta 1 mRNA could be demonstrated. The results suggest that IFN-beta 2 has biological functions distinct from the other interferons.

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Year:  1986        PMID： 2871942     DOI： 10.1016/0092-8674(86)90780-4

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  154 in total

1.  On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion.

Authors:  A Ray; K S LaForge; P B Sehgal
Journal:  Mol Cell Biol       Date:  1990-11       Impact factor: 4.272

2.  Replication of Toxoplasma gondii, but not Trypanosoma cruzi, is regulated in human fibroblasts activated with gamma interferon: requirement of a functional JAK/STAT pathway.

Authors:  I P Cerávolo; A C Chaves; C A Bonjardim; D Sibley; A J Romanha; R T Gazzinelli
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

3.  Intrinsic growth deficiencies of mesenchymal stromal cells in myelodysplastic syndromes.

Authors:  Carmen Mariana Aanei; Pascale Flandrin; Florin Zugun Eloae; Eugen Carasevici; Denis Guyotat; Eric Wattel; Lydia Campos
Journal:  Stem Cells Dev       Date:  2011-10-27       Impact factor: 3.272

4.  Beta interferon subtype 1 induction by tumor necrosis factor.

Authors:  H Jacobsen; J Mestan; S Mittnacht; C W Dieffenbach
Journal:  Mol Cell Biol       Date:  1989-07       Impact factor: 4.272

5.  Recombinant human cachectin/tumor necrosis factor but not interleukin-1 alpha downregulates lipoprotein lipase gene expression at the transcriptional level in mouse 3T3-L1 adipocytes.

Authors:  R Zechner; T C Newman; B Sherry; A Cerami; J L Breslow
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

6.  Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

Authors:  J M Le; G Fredrickson; L F Reis; T Diamantstein; T Hirano; T Kishimoto; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

7.  Species-specific TNF induction of thymocyte proliferation.

Authors:  M J Ehrke; R L Ho; K Hori
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

8.  Release of cytokines during generation of lymphokine-activated killer (LAK) cells by IL-2.

Authors:  G A Limb; A Meager; J Woolley; M Wadhwa; J Biggerstaff; K A Brown; R A Wolstencroft
Journal:  Immunology       Date:  1989-12       Impact factor: 7.397

9.  A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation.

Authors:  A Ray; P Sassone-Corsi; P B Sehgal
Journal:  Mol Cell Biol       Date:  1989-12       Impact factor: 4.272

10.  Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

Authors:  R De Caterina; P Libby; H B Peng; V J Thannickal; T B Rajavashisth; M A Gimbrone; W S Shin; J K Liao
Journal:  J Clin Invest       Date:  1995-07       Impact factor: 14.808
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