Literature DB >> 2661256

Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokine.

M Revel1.   

Abstract

IL-6/IFN-beta 2 appears to be one of the important mediators of the response to viral and bacterial infections and to shock. The biological effects now associated with IL-6/IFN-beta 2 include: stimulation of immunoglobulin secretion by mature B lymphocytes (BSF-2 activity), growth stimulation of plasmacytomas and hybridomas (HGF activity), activation of T cells, stimulation of hepatic acute phase protein synthesis (HSF activity), stimulation of hematopoiesis, cell differentiation (DIF activity), inhibition of tumor cell growth (AP activity) and other IFN-like effects. As a typical cytokine, IL-6/IFN-beta 2 is secreted by many cell types and acts in various combinations with other interleukins and interferons.

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Year:  1989        PMID： 2661256     DOI： 10.1007/bf01990505

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  81 in total

1.  Activation of the human "beta 2-interferon/hepatocyte-stimulating factor/interleukin 6" promoter by cytokines, viruses, and second messenger agonists.

Authors:  A Ray; S B Tatter; L T May; P B Sehgal
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

2.  Human chromosome 7 carries the beta 2 interferon gene.

Authors:  P B Sehgal; A Zilberstein; R M Ruggieri; L T May; A Ferguson-Smith; D L Slate; M Revel; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

3.  Synergistic interactions of interleukin 1, interferon-beta, and tumor necrosis factor in terminally differentiating a mouse myeloid leukemic cell line (M1). Evidence that interferon-beta is an autocrine differentiating factor.

Authors:  K Onozaki; H Urawa; T Tamatani; Y Iwamura; T Hashimoto; T Baba; H Suzuki; M Yamada; S Yamamoto; J J Oppenheim
Journal:  J Immunol       Date:  1988-01-01       Impact factor: 5.422

4.  Recombinant human interleukin 6 (B-cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1).

Authors:  C Miyaura; K Onozaki; Y Akiyama; T Taniyama; T Hirano; T Kishimoto; T Suda
Journal:  FEBS Lett       Date:  1988-07-04       Impact factor: 4.124

5.  Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21.

Authors:  A C Ferguson-Smith; Y F Chen; M S Newman; L T May; P B Sehgal; F H Ruddle
Journal:  Genomics       Date:  1988-04       Impact factor: 5.736

6.  High-affinity binding sites for human 26-kDa protein (interleukin 6, B cell stimulatory factor-2, human hybridoma plasmacytoma growth factor, interferon-beta 2), different from those of type I interferon (alpha, beta), on lymphoblastoid cells.

Authors:  P G Coulie; A Vanhecke; J Van Damme; S Cayphas; P Poupart; L De Wit; J Content
Journal:  Eur J Immunol       Date:  1987-10       Impact factor: 5.532

7.  Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.

Authors:  T Hirano; K Yasukawa; H Harada; T Taga; Y Watanabe; T Matsuda; S Kashiwamura; K Nakajima; K Koyama; A Iwamatsu
Journal:  Nature       Date:  1986 Nov 6-12       Impact factor: 49.962

8.  Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha.

Authors:  A G Leary; K Ikebuchi; Y Hirai; G G Wong; Y C Yang; S C Clark; M Ogawa
Journal:  Blood       Date:  1988-06       Impact factor: 22.113

9.  Regulation of cell surface receptors for different hematopoietic growth factors on myeloid leukemic cells.

Authors:  J Lotem; L Sachs
Journal:  EMBO J       Date:  1986-09       Impact factor: 11.598

10.  Monocyte-conditioned medium, interleukin-1, and tumor necrosis factor stimulate the acute phase response in human hepatoma cells in vitro.

Authors:  G J Darlington; D R Wilson; L B Lachman
Journal:  J Cell Biol       Date:  1986-09       Impact factor: 10.539
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  6 in total

1.  Recombinant tumour necrosis factor-alpha decreases whereas recombinant interleukin-6 increases growth of a virulent strain of Mycobacterium avium in human macrophages.

Authors:  M Denis; E O Gregg
Journal:  Immunology       Date:  1990-09       Impact factor: 7.397

2.  Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo.

Authors:  M Machnicki; M Zimecki; T Zagulski
Journal:  Int J Exp Pathol       Date:  1993-10       Impact factor: 1.925

3.  Blunted IL-6 and IL-10 response to maximal aerobic exercise in patients with traumatic brain injury.

Authors:  Kyle L Timmerman; William E Amonette; Melissa M Markofski; Hayden A Ansinelli; Elizabeth A Gleason; Blake B Rasmussen; Kurt A Mossberg
Journal:  Eur J Appl Physiol       Date:  2014-09-12       Impact factor: 3.078

4.  Effect of periodontal therapy on crevicular fluid interleukin-6 and interleukin-8 levels in chronic periodontitis.

Authors:  Paschalina Goutoudi; Evdoxia Diza; Malamatenia Arvanitidou
Journal:  Int J Dent       Date:  2011-10-26

5.  Leukocyte activation by (1-->3)-beta-D glucans.

Authors:  Y Adachi; M Okazaki; N Ohno; T Yadomae
Journal:  Mediators Inflamm       Date:  1997       Impact factor: 4.711

6.  Cross-reactivity of commercially available anti-human monoclonal antibodies with canine cytokines: establishment of a reliable panel to detect the functional profile of peripheral blood lymphocytes by intracytoplasmic staining.

Authors:  Marcela L Moreira; Elaine M S Dorneles; Rodrigo P Soares; Camila P Magalhães; Christiane Costa-Pereira; Andrey P Lage; Andréa Teixeira-Carvalho; Olindo A Martins-Filho; Márcio S S Araújo
Journal:  Acta Vet Scand       Date:  2015-09-11       Impact factor: 1.695
  6 in total

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