| Literature DB >> 30528233 |
Linrui Jiang1, Shuqin Zhang2, Huazhong Hu3, Jing Yang4, XiaoYan Wang5, Yanyan Ma6, JiaoHua Jiang7, JinHong Wang8, Lin Zhong9, Ming Chen10, Hong Wang11, Yu Hou12, RuiRui Zhu13, Qun Zhang14.
Abstract
Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-EXOs) play an important role in the regulation of the immune system and inflammatory responses; however, their role in acute liver failure (ALF) and related pathological conditions is unclear. In this study, we found that hUCMSC-EXOs can reduce the expression of the NLRP3 inflammasome and downstream inflammatory factors in acute liver failure. Western blot and ELISA results showed that hUCMSC-EXOs decreased the expression of NLRP3, caspase-1, IL-1β and IL-6 in LPS-stimulated RAW 264.7 macrophages. In vivo, the hUCMSC-EXOs repaired damaged liver tissue and decreased the expression of the NLRP3 inflammasome and the levels of ALT and AST in a mouse ALF model. The results of this study provide a new strategy for the application of human umbilical cord mesenchymal stem cell-derived exosomes in the treatment of ALF.Entities:
Keywords: Acute liver failure; Exosome; Human umbilical cord mesenchymal stem cells; Macrophage; NLRP3 inflammasome
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Year: 2018 PMID： 30528233 DOI： 10.1016/j.bbrc.2018.11.189
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575