Literature DB >> 30482469

Exome sequencing disclosures in pediatric cancer care: Patterns of communication among oncologists, genetic counselors, and parents.

Sarah Scollon1, Mary A Majumder2, Katie Bergstrom3, Tao Wang4, Amy L McGuire5, Jill O Robinson6, Amanda M Gutierrez7, Caroline H Lee8, Susan G Hilsenbeck9, Sharon E Plon10, D Williams Parsons11, Richard L Street12.   

Abstract

OBJECTIVE: To examine communication patterns and behaviors during disclosure of exome sequencing (ES) results to parents of pediatric cancer patients, and describe common themes in parental communication.
METHODS: Using mixed methods, we analyzed transcripts of sessions where parents of pediatric cancer patients received ES results from an oncologist and genetic counselor. Seventy-six transcripts were analyzed for frequency of clinician information-giving, partnering-supportive talk, and active parent participation. A subset of 40 transcripts were analyzed using thematic content analysis.
RESULTS: Disclosures consisted mostly of clinician talk (84% of total talk), which was focused on providing information (62% of clinicians' utterances) with occasional partnering-supportive talk (7% of clinicians' utterances). Most parents assumed a passive, listening role (16% of total talk). Themes in parental communication included expressing relief and the significance of an answer, concern about sharing results and responsibility for inheritance, and seeking clarification of health implications of results.
CONCLUSION: Our finding of low levels of active parent participation during ES disclosures highlights the need to improve patient/parent engagement and understanding in a genetic setting. PRACTICE IMPLICATIONS: Clinician communication strategies that could encourage parent participation and understanding include checking for parent understanding, partnership-building, and tailoring ES discussions to address parent concerns and preferences.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Clinician-patient communication; Exome sequencing; Genetic counseling; Return of results

Mesh:

Year:  2018        PMID: 30482469      PMCID: PMC6440863          DOI: 10.1016/j.pec.2018.11.007

Source DB:  PubMed          Journal:  Patient Educ Couns        ISSN: 0738-3991


  35 in total

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Authors:  D Feldman-Stewart; M D Brundage; C Tishelman
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2.  Variation in question asking during cancer clinical interactions: a potential source of disparities in access to information.

Authors:  Susan Eggly; Felicity W K Harper; Louis A Penner; Marci J Gleason; Tanina Foster; Terrance L Albrecht
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3.  Patient participation in deciding breast cancer treatment and subsequent quality of life.

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Journal:  Med Decis Making       Date:  1997 Jul-Sep       Impact factor: 2.583

4.  Consultations between patients with breast cancer and surgeons: a pathway from patient-centered communication to reduced hopelessness.

Authors:  Jeffrey D Robinson; Donald R Hoover; Maria K Venetis; Thomas J Kearney; Richard L Street
Journal:  J Clin Oncol       Date:  2012-12-10       Impact factor: 44.544

5.  Racial differences in doctors' information-giving and patients' participation.

Authors:  Howard S Gordon; Richard L Street; Barbara F Sharf; Julianne Souchek
Journal:  Cancer       Date:  2006-09-15       Impact factor: 6.860

6.  Cancer communication patterns and the influence of patient characteristics: disparities in information-giving and affective behaviors.

Authors:  Laura A Siminoff; Gregory C Graham; Nahida H Gordon
Journal:  Patient Educ Couns       Date:  2006-07-24

7.  Family stories and the use of heuristics: women from suspected hereditary breast and ovarian cancer (HBOC) families.

Authors:  Regina Kenen; Audrey Ardern-Jones; Rosalind Eeles
Journal:  Sociol Health Illn       Date:  2003-11

8.  Physicians' decision-making style and psychosocial outcomes among cancer survivors.

Authors:  Neeraj K Arora; Kathryn E Weaver; Marla L Clayman; Ingrid Oakley-Girvan; Arnold L Potosky
Journal:  Patient Educ Couns       Date:  2009-11-04

9.  Is Whole-Exome Sequencing an Ethically Disruptive Technology? Perspectives of Pediatric Oncologists and Parents of Pediatric Patients With Solid Tumors.

Authors:  Laurence B McCullough; Melody J Slashinski; Amy L McGuire; Richard L Street; Christine M Eng; Richard A Gibbs; D William Parsons; Sharon E Plon
Journal:  Pediatr Blood Cancer       Date:  2015-10-27       Impact factor: 3.167

10.  Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors.

Authors:  D Williams Parsons; Angshumoy Roy; Yaping Yang; Tao Wang; Sarah Scollon; Katie Bergstrom; Robin A Kerstein; Stephanie Gutierrez; Andrea K Petersen; Abhishek Bavle; Frank Y Lin; Dolores H López-Terrada; Federico A Monzon; M John Hicks; Karen W Eldin; Norma M Quintanilla; Adekunle M Adesina; Carrie A Mohila; William Whitehead; Andrew Jea; Sanjeev A Vasudevan; Jed G Nuchtern; Uma Ramamurthy; Amy L McGuire; Susan G Hilsenbeck; Jeffrey G Reid; Donna M Muzny; David A Wheeler; Stacey L Berg; Murali M Chintagumpala; Christine M Eng; Richard A Gibbs; Sharon E Plon
Journal:  JAMA Oncol       Date:  2016-05-01       Impact factor: 31.777

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  5 in total

1.  Characterizing patient-oncologist communication in genomic tumor testing: The 21-gene recurrence score as an exemplar.

Authors:  Suzanne C O'Neill; Susan T Vadaparampil; Richard L Street; Tanina Foster Moore; Claudine Isaacs; Hyo S Han; Bianca Augusto; Jennifer Garcia; Katherine Lopez; Matilda Brilleman; Jinani Jayasekera; Susan Eggly
Journal:  Patient Educ Couns       Date:  2020-09-03

Review 2.  Cancer Genetic Counseling-Current Practice and Future Challenges.

Authors:  Jaclyn Schienda; Jill Stopfer
Journal:  Cold Spring Harb Perspect Med       Date:  2020-06-01       Impact factor: 5.159

3.  Families with complex needs: an inside perspective from young people, their carers, and healthcare providers.

Authors:  Mădălina Radu; Ramona Moldovan; Adriana Băban
Journal:  J Community Genet       Date:  2022-03-18

4.  Germline whole genome sequencing in pediatric oncology in Denmark-Practitioner perspectives.

Authors:  Anna Byrjalsen; Ulrik K Stoltze; Anders Castor; Ayo Wahlberg
Journal:  Mol Genet Genomic Med       Date:  2020-06-04       Impact factor: 2.183

5.  Examining access to care in clinical genomic research and medicine: Experiences from the CSER Consortium.

Authors:  Amanda M Gutierrez; Jill O Robinson; Simon M Outram; Hadley S Smith; Stephanie A Kraft; Katherine E Donohue; Barbara B Biesecker; Kyle B Brothers; Flavia Chen; Benyam Hailu; Lucia A Hindorff; Hannah Hoban; Rebecca L Hsu; Sara J Knight; Barbara A Koenig; Katie L Lewis; Kristen Hassmiller Lich; Julianne M O'Daniel; Sonia Okuyama; Gail E Tomlinson; Margaret Waltz; Benjamin S Wilfond; Sara L Ackerman; Mary A Majumder
Journal:  J Clin Transl Sci       Date:  2021-09-14
  5 in total

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