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Literature DB >> 2555792

A negative regulatory element in the promoter of the human alpha 1-antitrypsin gene.

Abstract

A "minimal tissue-specific element" of the human alpha 1-antitrypsin (alpha 1-AT) gene promoter, located in the -137/-37 region, is able to drive hepatoma-specific transcription from the heterologous SV40 promoter. Here we show that, in HeLa cells, this element is inactivated by a negative regulatory mechanism. This negative control can be overcome by deletion or mutation of two specific DNA domains.

Entities: Disease Gene Species

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Year: 1989 PMID： 2555792 PMCID： PMC335141 DOI： 10.1093/nar/17.22.9407

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

22 in total

1. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors: A J Berk; P A Sharp
Journal: Cell Date: 1977-11 Impact factor: 41.582

2. The human growth hormone gene contains both positive and negative control elements.

Authors: L N Peritz; E J Fodor; D W Silversides; P A Cattini; J D Baxter; N L Eberhardt
Journal: J Biol Chem Date: 1988-04-15 Impact factor: 5.157

Review 3. The transcriptional regulation of liver-specific gene expression.

Authors: V de Simone; R Cortese
Journal: Oxf Surv Eukaryot Genes Date: 1988

4. A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors: F L Graham; A J van der Eb
Journal: Virology Date: 1973-04 Impact factor: 3.616

5. Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

Authors: R Ehrlich; J E Maguire; D S Singer
Journal: Mol Cell Biol Date: 1988-02 Impact factor: 4.272

6. Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions.

Authors: H K Das; T Leff; J L Breslow
Journal: J Biol Chem Date: 1988-08-15 Impact factor: 5.157

7. Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.

Authors: K Reue; T Leff; J L Breslow
Journal: J Biol Chem Date: 1988-05-15 Impact factor: 5.157

4. Restricted tissue-specific but correct developmental expression mediated by a short human alpha 1AT promoter fragment in transgenic mice.

Authors: F E Yull; R M Wallace; A J Clark
Journal: Transgenic Res Date: 1995-01 Impact factor: 2.788

4 in total

A negative regulatory element in the promoter of the human alpha 1-antitrypsin gene.

1. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

2. The human growth hormone gene contains both positive and negative control elements.

Review 3. The transcriptional regulation of liver-specific gene expression.

4. A new technique for the assay of infectivity of human adenovirus 5 DNA.

5. Identification of negative and positive regulatory elements associated with a class I major histocompatibility complex gene.

6. Cell type-specific expression of the human apoB gene is controlled by two cis-acting regulatory regions.

7. Human apolipoprotein CIII gene expression is regulated by positive and negative cis-acting elements and tissue-specific protein factors.

8. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

9. Two distinct factors interact with the promoter regions of several liver-specific genes.

10. Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter.

1. The SV40 early transcriptional regulatory element is unable to direct gene expression in pituitary GH-3 cells.

2. Regulation of mouse serum amyloid A gene expression in transfected hepatoma cells.

3. Negative and positive cis-acting elements control the expression of murine alpha 1-protease inhibitor genes.

4. Restricted tissue-specific but correct developmental expression mediated by a short human alpha 1AT promoter fragment in transgenic mice.